Retrospective Cohort Study of Diabetes Mellitus and Antipsychotic Treatment in a Geriatric Population in the United States

Feldman, Peter D.; Hay, Linda K.; Deberdt, Walter; Kennedy, John S.; Hutchins, David S.; Hay, Donald P.; Hardy, Thomas A.; Hoffmann, Vicki P.; Hornbuckle, Kenneth; Breier, Alan

« Previous Next »JAMDA
Volume 5, Issue 1 , Pages 38-46, January 2004

Retrospective Cohort Study of Diabetes Mellitus and Antipsychotic Treatment in a Geriatric Population in the United States

Peter D. Feldman, PhD
- Lilly Research Laboratories, Indianapolis, IN
- Address correspondence to Peter D. Feldman, PhD, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285.
Linda K. Hay, PhD
- Lilly Research Laboratories, Indianapolis, IN
- Deceased.
Walter Deberdt, MD
- Lilly Research Laboratories, Indianapolis, IN
John S. Kennedy, MD
- Indiana University School of Medicine, Indianapolis, IN
David S. Hutchins, MHSA
- AdvancePCS, Inc., Scottsdale, AZ
Donald P. Hay, MD
- Lilly Research Laboratories, Indianapolis, IN
Thomas A. Hardy, MD
- Lilly Research Laboratories, Indianapolis, IN
Vicki P. Hoffmann, PharmD
- Lilly Research Laboratories, Indianapolis, IN
Kenneth Hornbuckle, DVM, PhD, MPH
- Lilly Research Laboratories, Indianapolis, IN
Alan Breier, MD
- Lilly Research Laboratories, Indianapolis, IN

Objectives

The objective of this study was to investigate risk of diabetes among elderly patients during treatment with antipsychotic medications.

Design

We conducted a longitudinal, retrospective study assessing the incidence of new prescription claims for antihyperglycemic agents during antipsychotic therapy.

Setting

Prescription claims from the AdvancePCS claim database were followed for 6 to 9 months.

Participants

Study participants consisted of patients in the United States aged 60+ and receiving antipsychotic monotherapy. The following cohorts were studied: an elderly reference population (no antipsychotics: n = 1,836,799), those receiving haloperidol (n = 6481) or thioridazine (n = 1658); all patients receiving any conventional antipsychotic monotherapy (n = 11,546), clozapine (n = 117), olanzapine (n = 5382), quetiapine (n = 1664), and risperidone (n = 12,244), and all patients receiving any atypical antipsychotic monotherapy (n = 19,407).

Measurements

We used Cox proportional hazards regression to determine the risk ratio of diabetes for antipsychotic cohorts relative to the reference population. Covariates included sex and exposure duration.

Results

New antihyperglycemic prescription rates were higher in each antipsychotic cohort than in the reference population. Overall rates were no different between atypical and conventional antipsychotic cohorts. Among individual antipsychotic cohorts, rates were highest among patients treated with thioridazine (95% confidence interval [CI], 3.1–5.7), lowest with quetiapine (95% CI, 1.3–2.9), and intermediate with haloperidol, olanzapine, and risperidone. Among atypical cohorts, only risperidone users had a significantly higher risk (95% CI, 1.05–1.60; P = 0.016) than for haloperidol. Conclusions about clozapine were hampered by the low number of patients.

Conclusion

These data suggest that diabetes risk is elevated among elderly patients receiving antipsychotic treatment. However, causality remains to be demonstrated. As a group, the risk for atypical antipsychotic users was not significantly different than for users of conventional antipsychotics.

Keywords: Antipsychotics , diabetes mellitus , geriatrics , prescriptions , drug