JAMDA
Volume 3, Issue 3 , Pages 175-179 , May 2002

Clinical Presentations in Monozygotic Twins with Dementia with Lewy Bodies

  • K.S. SantaCruz, MD

      Affiliations

    • Departments of Pathology and Laboratory Medicine and Neurology, Center on Aging, University of Kansas School of Medicine, Kansas City, Kansas
    • Corresponding Author InformationAddress correspondence to: Karen S. SantaCruz, MD, Department of Pathology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, Kansas, 66160-7410.
    • ,
  • Z. Walker, MD, MRCS, MRCPsych

      Affiliations

    • Royal Free and University College Medical School, University College London, Department of Psychiatry and Behavioral Sciences, London, United Kingdom
    • ,
  • D. Swagerty, MD, MPH, CMD

      Affiliations

    • Departments of Family Medicine and Internal Medicine, Center on Aging, University of Kansas School of Medicine, Kansas City, Kansas
    • ,
  • M.A. Piggott, PhD

      Affiliations

    • Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle-upon-Tyne, UK
    • ,
  • M. Ryo-Yang, MD, PhD

      Affiliations

    • Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle-upon-Tyne, UK
    • ,
  • I.G. McKeith, FRCPsych, MD

      Affiliations

    • Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle-upon-Tyne, UK
    • ,
  • R. Raghavan, MBBS, MD, MRCPath

      Affiliations

    • University of Texas Southwestern Medical Center, Dallas, Texas, USA
    • ,
  • E. Jaros, PhD

      Affiliations

    • Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle-upon-Tyne, UK
    • ,
  • R.H. Perry, MBChB, FRC Path

      Affiliations

    • Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle-upon-Tyne, UK

References 

  1. McKeith IG, Galasko D, Kosaka D, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop. Neurology. 1996;47:1113–1124
  2. Perry RH, McKeith IG, Perry EK. Dementia with Lewy Bodies. New York: Cambridge, Melbourne: Cambridge University Press; 1996;
  3. Del Ser T, McKeith I, Anand R, et al. Dementia with Lewy bodies: Findings from an international multicentre study. Int J Geriatr Psychiatry. 2000;15:1034–1045
  4. Knopman DS. An overview of common non-Alzheimer dementias. Clin Geriatr Med. 2001;7:281–301
  5. Duda JE, Lee VM, Trojanowski JQ. Neuropathology of synuclein aggregates. J Neurosci Res. 2000;61:121–127
  6. McKeith IG, Grace JB, Walker Z, et al. Rivastigmine in the treatment of dementia with Lewy bodies: Preliminary findings from an open trial. Int J Geriatr Psychiatry. 2000;15:387–392
  7. Grace JB, Walker MP, McKeith IG. A comparison of sleep profiles in patients with dementia with Lewy bodies and Alzheimer's disease. Int J Geriatr Psychiatry. 2000;15:1028–1033
  8. Skjerve A, Nygaard HA. Improvement in sundowning in dementia with Lewy bodies after treatment with donepezil. Int J Geriatr Psychiatry. 2000;15:1147–1151
  9. Ballard C, Piggott M, Johnson M, et al. Delusions associated with elevated muscarinic binding in dementia with Lewy bodies. Ann Neurol. 2000;48:868–876
  10. McKeith I, Del Ser T, Spano P, et al. Efficacy of rivastigmine in dementia with Lewy bodies: A randomized, double blind, placebo-controlled international study. Lancet. 2000;356:2031–2036
  11. Campbell S, Stephens S, Ballard C. Dementia with Lewy bodies: clinical features and treatment. Drugs Aging. 2001;18:397–407
  12. Muenter MD, Forno LS, Hornykiewicz O, et al. Hereditary form of parkinsonism–dementia. Ann Neurol. 1998;43:768–781
  13. Ohara K, Takauchi S, Kokai M, et al. Familial dementia with Lewy bodies (DLB). Clin Neuropath. 1999;18:232–239
  14. Gwinn-Hardy K, Mehta ND, Farrer M, et al. Distinctive neuropathology revealed by alpha-synuclein antibodies in hereditary parkinsonism and dementia linked to chromosom 4p,. Acta Neuropathol (Berl). 2000;99:663–672
  15. Ince P, Irving D, MacArthur F, Perry RH. Quantitative neuropathological study of Alzheimer-type pathology in the hippocampus: Comparison of senile dementia of Alzheimer type, senile dementia of Lewy body type, Parkinson's disease and non-demented elderly controls. J Neurol Sci. 1991;106:142–152
  16. Walker MP, Ayre GA, Perry EK, et al. Quantification and characterisation of fluctuating cognition in dementia with Lewy bodies and Alzheimer's disease. Dement Geriatr Cogn Disord. 2000;11:327–335
  17. Ballard C, Walker M, O'Brien J, et al. The characterisation and impact of ‘fluctuating’ cognition in dementia with Lewy bodies and Alzheimer's disease. Int J Geriatr Psychiatry. 2001;16:494–498
  18. Farrer M, Gwinn-Hardy K, Hutton M, Hardy J. The genetics of disorders with synuclein pathology and parkinsonism. Hum Mol Genet. 1999;8:1901–1905
  19. Xu W, Liu L, Emson P, et al. The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies. Neuroreport. 2000;11:297–299
  20. Piggott MA, Marshall EF, Thomas N, et al. Striatal dopaminergic markers in dementia with Lewy bodies. Alzheimer's and Parkinson's diseases: rostrocaudal distribution, Brain. 1999;122:1449–1468
  21. Court JA, Piggott MA, Lloyd S, et al. Nicotine binding in human striatum: Elevation in schizophrenia and reductions in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease and in relation to neuroleptic medication. Neuroscience. 2000;98:79–87
  22. McKeith IG, Perry EK, Perry RH. Report of the second dementia with Lewy body international workshop, Neurology 53;1999:902–905

PII: S1525-8610(04)70461-2

doi: 10.1016/S1525-8610(04)70461-2

JAMDA
Volume 3, Issue 3 , Pages 175-179 , May 2002

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