JAMDA
Volume 7, Issue 3 , Pages 193-196 , March 2006

Drug Therapy of Older Persons With Hypertension

  • Wilbert S. Aronow, MD, CMD

      Affiliations

    • Corresponding Author InformationAddress correspondence to Wilbert S. Aronow, MD, CMD, Cardiology Division, New York Medical College, Macy Pavilion, Room 138, Valhalla, NY 10595

References 

  1. Aronow WS , Ahn C , Gutstein H . Prevalence and incidence of cardiovascular disease in 1160 older men and 2464 older women in a long-term health care facility . J Gerontol A Biol Sci Med Sci . 2002;57A:M45–M46
  2. Mendelson G , Ness J , Aronow WS . Drug treatment of hypertension in older persons in an academic hospital-based geriatrics practice . J Am Geriatr Soc . 1999;47:597–599
  3. National High Blood Pressure Education Program Working Group . National High Blood Pressure Education Program working group report on hypertension in the elderly . Hypertens . 1994;23:275–285
  4. Madhavan S , Ooi WL , Cohen H , Alderman MH . Relation of pulse pressure and blood pressure reduction to the incidence of myocardial infarction . Hypertens . 1994;23:395–401
  5. Aronow WS , Ahn C . Risk factors for new coronary events in a large cohort of very elderly patients with and without coronary artery disease . Am J Cardiol . 1996;77:864–866
  6. Aronow WS , Ahn C , Gutstein H . Risk factors for new atherothrombotic brain infarction in 664 older men and 1,488 older women . Am J Cardiol . 1996;77:1381–1383
  7. Aronow WS , Ahn C , Kronzon I , Koenigsberg M . Congestive heart failure, coronary events and atherothrombotic brain infarction in elderly blacks and whites with systemic hypertension and with and without echocardiographic and electrocardiographic evidence of left ventricular hypertrophy . Am J Cardiol . 1991;67:295–299
  8. Aronow WS , Ahn C , Kronzon I . Comparison of incidences of congestive heart failure in older African-Americans, Hispanics, and whites . Am J Cardiol . 1999;84:611–612
  9. Aronow WS , Sales FF , Etienne F , Lee NH . Prevalence of peripheral arterial disease and its correlation with risk factors for peripheral arterial disease in elderly patients in a long-term health care facility . Am J Cardiol . 1988;62:644–646
  10. Chobanian AV , Bakris GL , Black HR , et al.   The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. The JNC 7 Report . JAMA . 2003;289:2560–2572
  11. Aronow WS , Frishman WH . Treatment of hypertension and prevention of ischemic stroke . Curr Cardiol Rep . 2004;6:124–129
  12. Progress Collaborative Group . Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack . Lancet . 2001;358:1033–1041
  13. Forette F , Seux M-L , Staessen JA , et al.   The prevention of dementia with antihypertensive treatment. New evidence from the Systolic Hypertension in Europe (Syst-Eur) study . Arch Intern Med . 2002;162:2046–2052
  14. Murray MD , Lane KA , Gao S , et al.   Preservation of cognitive function with antihypertensive medications. A longitudinal analysis of a community-based sample of African Americans . Arch Intern Med . 2002;162:2090–2096
  15. Veld BA , Ruitenberg A , Holman A , et al.   Antihypertensive drugs and incidence of dementia (The Rotterdam Study) . Neurobiol Aging . 2001;22:407–412
  16. Gueyffier F , Bulpitt C , Boissel J-P , et al.   Antihypertensive drugs in very old people (A subgroup meta-analysis of randomised controlled trials) . Lancet . 1999;353:793–796
  17. Hansson L , Zanchetti A , Carruthers SG , et al.   Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension (Principal result of the Hypertension Optimal Treatment (HOT) randomised trial) . Lancet . 1998;351:1755–1762
  18. Gandelman G , Aronow WS , Varma R . Prevalence of adequate blood pressure control in self-pay or Medicare patients versus Medicaid or private insurance patients with systemic hypertension followed in a university cardiology or general medicine clinic . Am J Cardiol . 2004;94:815–816
  19. Mendelson G , Nassimiha D , Aronow WS . Simultaneous measurements of blood pressures in right and left brachial arteries . Cardiol Rev . 2004;12:276–278
  20. Ryan TJ , Antman EM , Brooks NH , et al.   1999 update: ACC/AHA guidelines for the management of patients with acute myocardial infarction: Executive summary and recommendations. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction) . Circulation . 1999;100:1016–1030
  21. The Heart Outcomes Prevention Evaluation Study Investigators . Effects of an angiotensin-converting-enzyme inhibitor, ramipril on cardiovascular events in high-risk patients . N Engl J Med . 2000;342:145–153
  22. Aronow WS , Ahn C , Kronzon I . Effect of beta blockers alone, of angiotensin-converting enzyme inhibitors alone, and of beta blockers plus angiotensin-converting enzyme inhibitors on new coronary events and on congestive heart failure in older persons with healed myocardial infarcts and asymptomatic left ventricular systolic dysfunction . Am J Cardiol . 2001;88:1298–1300
  23. Aronow WS , Ahn C . Effect of beta blockers on incidence of new coronary events in older persons with prior myocardial infarction and diabetes mellitus . Am J Cardiol . 2001;87:780–781
  24. Aronow WS , Ahn C . Effect of beta blockers on incidence of new coronary events in older persons with prior myocardial infarction and symptomatic peripheral arterial disease . Am J Cardiol . 2001;87:1284–1286
  25. Pahor M , Psaty BM , Alderman MH , et al.   Health outcomes associated with calcium antagonists compared with other first-line antihypertensive therapies (A meta-analysis of randomised controlled trials) . Lancet . 2000;356:1949–1954
  26. ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group . Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) . JAMA . 2000;283:1967–1975
  27. Aronow WS , Ahn C . Incidence of new coronary events in older persons with prior myocardial infarction and systemic hypertension treated with beta blockers, angiotensin-converting enzyme inhibitors, diuretics, calcium antagonists, and alpha blockers . Am J Cardiol . 2002;89:1207–1209
  28. Bryson CL , Smith NL , Kuller LH , et al.   Risk of congestive heart failure in an elderly population treated with peripheral alpha-1 antagonists . J Am Geriatr Soc . 2004;52:1648–1654
  29. Kennedy HL , Brooks MM , Barker AH , et al.   Beta-blocker therapy in the Cardiac Arrhythmia Suppression Trial . Am J Cardiol . 1994;74:674–680
  30. Aronow WS , Ahn C , Mercando AD , et al.   Effect of propranolol versus no antiarrhythmic drug on sudden cardiac death, total cardiac death, and total death in patients ≥62 years of age with heart disease, complex ventricular arrhythmias, and left ventricular ejection fraction ≥40% . Am J Cardiol . 1994;74:267–270
  31. MERIT-HF Study Group . Effect of metoprolol CR/XL in chronic heart failure (Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)) . Lancet . 1999;353:2001–2007
  32. Aronow WS , Ahn C , Kronzon I . Effect of propranolol versus no propranolol on total mortality plus nonfatal myocardial infarction in older patients with prior myocardial infarction, congestive heart failure, and left ventricular ejection fraction ≥40% treated with diuretics plus angiotensin-converting-enzyme inhibitors . Am J Cardiol . 1997;80:207–209
  33. Aronow WS , Frishman WH . Angina in the elderly . In:  Aronow WS ,  Fleg JL editor. Cardiovascular Disease in the Elderly . 3rd ed.. New York, NY: Marcel Dekker, Inc; 2004;p. 273–295
  34. Aronow WS , Ahn C , Mercando AD , et al.   Decrease of mortality by propranolol in patients with heart disease and complex ventricular arrhythmias is more an anti-ischemic than an antiarrhythmic effect . Am J Cardiol . 1994;74:613–615
  35. Aronow WS . Management of the older person with atrial fibrillation . J Gerontol A Biol Sci Med Sci . 2002;57A:M352–M363
  36. Aronow WS . The heart and thyroid disease . In:  Gambert SR editors. Clinics in Geriatric Medicine. Thyroid Disease . Philadelphia: W. B. Saunders Co; 1995;p. 219–229
  37. Aronow WS . Might losartan reduce sudden cardiac death in diabetic patients with hypertension? . Lancet . 2003;362:591–592
  38. Carlberg B , Samuelsson O , Lindholm LH . Atenolol in hypertension (Is it a wise choice?) . Lancet . 2004;364:1684–1689
  39. Hunt SA , Baker DW , Chin MH , et al.   ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: Executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure). Developed in collaboration with the International Society for Heart and Lung Transplantation. Endorsed by the Heart Failure Society of America . J Am Coll Cardiol . 2001;38:2101–2113
  40. Aronow WS . Epidemiology, pathophysiology, prognosis, and treatment of systolic and diastolic heart failure in elderly patients . Heart Disease . 2003;5:279–294
  41. Agodoa LY , Appel L , Bakris GL , et al.   Effect of ramipril versus amlodipine on renal outcomes in hypertensive nephrosclerosis. A randomized controlled trial . JAMA . 2001;285:2719–2728
  42. Brenner BM , Cooper ME , de Zeeuw D , et al.   Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy . N Engl J Med . 2001;345:861–869
  43. Aronow WS . Dizziness and syncope . In:  Hazzard WR ,  Blass JP ,  Ettinger WH ,  Halter JB ,  Ouslander JG editor. Principles of Geriatric Medicine and Gerontology . 4th ed.. New York, NY: McGraw-Hill, Inc; 1998;p. 1519–1534
  44. Ziesmer V , Ghosh S , Aronow WS . Use of antihypertensive drug therapy in older persons in an academic nursing home . J Am Med Dir Assoc . 2002;3:243–245

PII: S1525-8610(05)00576-1

doi: 10.1016/j.jamda.2005.10.007

JAMDA
Volume 7, Issue 3 , Pages 193-196 , March 2006

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