JAMDA
Volume 10, Issue 2 , Pages 115-119 , February 2009

Atypical Antipsychotics and the Risk of Diabetes in an Elderly Population in Long-Term Care: A Retrospective Nursing Home Chart Review Study

Some data from this study were presented as part of a Plenary Symposium titled ”Psychosis in the Elderly” at the Silver Congress of the International Psychogeriatric Association, October 15, 2007, Osaka, Japan.

  • Stewart G. Albert, MD

      Affiliations

    • Department of Internal Medicine, Division of Endocrinology, Saint Louis University School of Medicine, St. Louis, MO
    • Corresponding Author InformationAddress correspondence to Stewart G. Albert, MD, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, MO 63104
    • ,
  • George T. Grossberg, MD

      Affiliations

    • Department of Neurology and Psychiatry, Division of Geriatric Psychiatry, Saint Louis University School of Medicine, St. Louis, MO
    • ,
  • Papan J. Thaipisuttikul, MD

      Affiliations

    • Department of Neurology and Psychiatry, Division of Geriatric Psychiatry, Saint Louis University School of Medicine, St. Louis, MO
    • ,
  • Jarod Scouby, BS
    • ,
  • Erin Green

References 

  1. Sink KM, Holden KF, Yaffe K. Pharmacological treatment of neuropsychiatric symptoms of dementia. A Review of the Evidence JAMA. 2005;293:596–608
  2. Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia (Meta-analysis of randomized placebo-controlled trials). JAMA. 2005;294:1934–1943
  3. Wang PS, Schneeweis S, Avorn J, et al. Risk of death in elderly users of conventional vs. atypical antipsychotic medications. N Eng J Med. 2005;353:2335–2341
  4. Schneider LS, Tariot PN, Lyketsos CG, et al. National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Alzheimer Disease Trial Methodology. Am J Geriatr Psychiatry. 2001;9:346–360
  5. American Diabetes AssociationAmerican Psychiatric AssociationAmerican Association of Clinical EndocrinologistNorth American Association for the Study of Obesity. Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes. Diabetes Care. 2004;27:596–601
  6. Gianfrancesco FD, Grogg AL, Mahmoud RA, et al. Differential effects of risperidone, olanzapine, clozapine, and conventional antipsychotics on type 2 diabetes: Findings from a large health plan database. J Clin Psychiatry. 2002;63:920–930
  7. Buse JB, Cavazzoni P, Hornbuckle K, et al. A retrospective cohort study of diabetes mellitus and antipsychotic treatment in the United States. J Clin Epidemiol. 2003;56:164–170
  8. Leslie DL, Rosenheck RA. Incidence of newly diagnosed diabetes attributable to atypical antipsyhcotic medications. Am J Psychiatry. 2004;161:1709–1711
  9. Newcomer JW. Abnormalities of glucose metabolism associated with atypical antipsychotic drugs. J Clin Psychiatry. 2004;65(suppl):36–46
  10. Ader M, Kim SP, Catalano KJ, et al. Metabolic dysregulation with atypical antipsychotics occurs in the absence of underlying disease: a placebo-controlled study of olanzapine and risperidone in dogs. Diabetes. 2005;54:862–871
  11. Henderson DC, Cagliero E, Copeland PM, et al. Glucose metabolism in patients with schizophrenia treated with atypical antipsychotic agents: A frequently sampled intravenous glucose tolerance test and minimal model analysis. Arch Gen Psychiatry. 2005;62:19–28
  12. Schneider LS, Tariot PN, Dagerman KS, et al. CATIE-AD study group Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease. N Eng J Med. 2006;355:1525–1538
  13. Colton T. Longitudinal studies and the use of the life table. In: Statistics in Medicine. Boston: Little Brown and Co; 1974;p. 237–250
  14. Kenney SJ, Aubert RE, Geiss LS. Prevalence and incidence of non-insulin-dependent diabetes mellitus. In:  Harris MI,  Cowie CC,  Stern MP, et al. editor. Diabetes in America. 2nd edition. Bethesda, MD: National Institutes of Health; 1995;p. 47–68

 The authors have no conflicts of interest relating to this article.

PII: S1525-8610(08)00271-5

doi: 10.1016/j.jamda.2008.08.005

JAMDA
Volume 10, Issue 2 , Pages 115-119 , February 2009

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