JAMDA
Volume 10, Issue 5 , Pages 348-353 , June 2009

Inflammation Markers and Malnutrition as Risk Factors for Infections and Impaired Health-Related Quality of Life Among Older Nursing Home Residents

  • Liisa K. Kuikka, MD, PhD

      Affiliations

    • University of Helsinki, Department of General Practice and Helsinki University Hospital, Unit of General Practice, Finland
    • Corresponding Author InformationAddress correspondence to Liisa Kuikka, MD, PhD, University of Helsinki, Department of General Practice, PO Box 41, Mannerheimintie 172 PL 41, Fin-00014 Helskini, Finland.
  • ,
  • Seppo Salminen, PhD

      Affiliations

    • Functional Foods Forum, University of Turku, Finland
  • ,
  • Arthur Ouwehand, MD, PhD

      Affiliations

    • Functional Foods Forum, University of Turku, Finland
  • ,
  • Miguel Gueimonde, MD, PhD

      Affiliations

    • Functional Foods Forum, University of Turku, Finland
  • ,
  • Timo E. Strandberg, MD, PhD

      Affiliations

    • Department of Health Sciences/Geriatrics, University of Oulu, and Oulu University Hospital, Unit of General Practice, Oulu, Finland
  • ,
  • Ulla H. Finne-Soveri, MD, PhD

      Affiliations

    • STAKES, Helsinki, Finland
  • ,
  • Harri Sintonen, PhD

      Affiliations

    • University of Helsinki, Department of Public Health and FinOHTA/Stakes, Helsinki, Finland
  • ,
  • Kaisu H. Pitkälä, MD, PhD

      Affiliations

    • University of Helsinki, Department of General Practice and Helsinki University Hospital, Unit of General Practice, Finland

References 

  1. Saletti A, Lindgre EY, Johansson L, Cederholm T. Nutritional status according to mini nutritional assessment in an institutionalized elderly population in Sweden. Gerontology. 2000;46:139–145
  2. Suominen M, Muurinen S, Routasalo P, et al. Malnutrition and associated factors among aged residents in all nursing homes in Helsinki. Eur J Clin Nutr. 2005;59:578–583
  3. Lesourd BM. Nutrition and immunity in the elderly: Modification of immune responses with nutritional treatments. Am J Clin Nutr. 1997;66:S478–S484
  4. Dey DK, Rothenberg E, Sundh V, et al. Body mass index, weight change and mortality in the elderly. A 15 y longitudinal population study of 70y olds. Eur J Clin Nutr. 2001;55:482–492
  5. Crogan NL, Pasvogel A. The influence of protein-calorie malnutrition on quality of life in nursing homes. J Gerontol A Biol Sci Med Sci. 2003;58:159–164
  6. DeMartinis M, Franceschi C, Monti D, Ginaldi L. Inflammation markers predicting frailty and mortality in the elderly. Exp Mol Pathol. 2006;80:219–227
  7. Sullivan DH, Roberson PK, Johnson LE, et al. Association between inflammation-associated cytokines, serum albumins and mortality in the elderly. J Am Med Dir Assoc. 2007;8:458–463
  8. Castle SC. Clinical relevance of age-related immune dysfunction. Clin Infect Dis. 2000;331:578–585
  9. Ferrucci L, Penninx WJH, Volpato S, et al. Change in muscle strength explains accelerated decline of physical function in older women with high intetleukin-6 serum levels. J Am Geriatr Soc. 2002;50:1947–1954
  10. Morley JE, Baumgartner RN. Cytokine-related aging process. J Gerontol A Biol Sci Med Sci. 2004;59A:924–929
  11. Perls T, Terry D. Understanding the determinants of exceptional longevity. Ann Int Med. 2003;139:445–449
  12. Rea IM. Ageing in the 21st century. Where to and how will we get there? Report on the 10th Congress of the International Association of Biomedical Gerontology, the geriatrician's view. Exp Gerontol. 2004;39:283–284
  13. Yeh SS, Hafner A, Chang CK, et al. Risk factors relating blood markers of inflammation and nutritional status to survival in cachectic geriatric patients in a randomized clinical trial. J Am Geriatric Soc. 2004;52:1708–1712
  14. Marcantonio ER, Rudolph JL, Culley D, et al. Serum biomarkers for delirium. J Gerontol A Biol Sci Med Sci. 2006;61A:1281–1286
  15. Schneider SM, Veyres P, Pivot X, et al. Malnutrition is an independent factor associated with nosocomial infections. Br J Nutr. 2004;92:105–111
  16. Paillaud E, Herbaud S, Caillet P, et al. Relation between undernutrition and nosocomial infections in elderly patients. Age Ageing. 2005;34:619–625
  17. Pitkala KH, Strandberg TE, Finne Soveri UH, et al. Fermented cereal with specific bifidobacteria normalizes bowel movements in elderly nursing home residents. A randomized, controlled trial. J Nutr Health Ageing. 2007;11:305–311
  18. Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189–198
  19. Morris JN, Fries BE, Mehr DR, et al. MDS Cognitive Performance Scale. J Gerontol. 1994;49:M174–M182
  20. Morris JN, Hawes C, Murphy K, Nonemaker S. Long-term care resident assessment instrument user's manual version 2.0. Baltimore, MD: Health Care Financing Administration; October 1995;
  21. Guigoz Y, Vellas B, Garry PJ. Assessing the nutritional status of the elderly: the Mini Nutritional Assessment as part of the geriatric evaluation. Nutr Rev. 1996;54:S59–S65
  22. Vellas B, Guigoz Y, Garry PJ, et al. The Mini Nutritional Assessment (MNA) and its use in grading the nutritional state of elderly patients. Nutrition. 1999;15:116–122
  23. Vellas B, Villars H, Abellan G, et al. Overview of the MNA—Its history and challenges. J Nutr Health Aging. 2006;10:456–465
  24. Sintonen H. The 15D instrument of health-related quality of life: Properties and applications. Ann Med. 2001;33:328–336
  25. Stavem K, Froland SS, Hellum KB. Comparison of preference-based utilities of the 15D, EQ-5D and SF-6D in patients with HIV/AIDS. Qual Life Res. 2005;14:971–980
  26. Strandberg T, Pitkälä K, Sintonen H, et al. Usability, discriminant and prognostic validity of 15D instrument for health related quality of life in older population samples. In:  Huusko T,  Strandberg T,  Pitkala K editor. Can Older People's Quality of Life Be Measured? [Finnish.]. Helsinki: The Central Union for the Welfare of the Aged; 2006;p. 42–61
  27. Pitkala KH, Laurila JV, Strandberg TE, et al. Multicomponent geriatric intervention for elderly inpatients with delirium: Effects on costs and health-related quality of life. J Gerontol A Biol Sci Med Sci. 2008;63:56–61
  28. Ridker PM. C-reactive protein and the prediction of cardiovascular events among those at intermediate risk. J Am Coll Cardiol. 2007;49:2129–2138
  29. Hoth KF, Haley AP, Gunstad J, et al. Elevated C-reactive protein is related to cognitive decline in older adults with cardiovascular disease. J Am Geriatr Soc. 2008;56:1898–1903
  30. Peltola H, Jaakkola M. Serious bacterial infections. C-reactive protein as a serial index of severity. Clin Pediatr (Phila). 1988;27:532–537
  31. Young B, Gleeson M, Cripps AW. C-reactive protein. A critical review. Pathology. 1991;23:118–124
  32. Castaneda C, Charnley JM, Evans WJ, Crim MC. Elderly women accommodate to a low-protein diet with losses of body cell mass, muscle function and immune response. Am J Clin Nutr. 1995;62:30–39
  33. Kagansky N, Berner Y, Koren-Morag N, et al. Poor nutritional habits are predictors of poor outcome in very old hospitalized patients. Am J Clin Nutr. 2005;4:784–791
  34. Rudman D, Feller AG. Protein-calorie undernutrition in the nursing home. J Am Geriatr Soc. 1989;37:173–183
  35. Donini LM, Savina C, Rosano A, et al. MNA predictive value in the follow-up of geriatric patients. J Nutr Health Ageing. 2003;7:282–293
  36. Akner G, Cederholm T. Treatment of protein-energy malnutrition in chronic nonmalignant disorders. Am J Clin Nutr. 2001;74:6–24
  37. Tilvis RS, Kähönen-Väre MH, Jolkkonen J, et al. Predictors of cognitive decline and mortality of aged people over a 10-year period. J Gerontol A Biol Med Sci. 2004;59:268–274
  38. Yamamoto H, Watanabe T, Miyazaki A, et al. High prevalence of Chlamydia pneumoniae antibodies and increased high-sensitive C-reactive protein in patients with vascular dementia. J Am Geriatric Soc. 2005;53:583–589
  39. Strandberg TE, Tilvis RS. C-reactive protein, cardiovascular risk factors, and mortality in a prospective study in the elderly. Arterioscler Thromb Vasc Biol. 2000;20:1057–1060
  40. Jylhä M, Paavilainen P, Lehtomäki T, et al. Interleukin -1 receptor antagonist, interleukin-6 and C-reactive protein as predictors of mortality in nonagenarians: The vitality 90+ study. J Gerontol A Biol Sci Med Sci. 2007;62A:1016–1021
  41. Gariballa S, Forster S. Dietary supplementation and quality of life of older Patients: A randomized, double-blind, placebo-controlled trial. J Am Geriatr Soc. 2007;55:2030–2034

 Financial support for the original intervention study was obtained from the National Technology Agency of Finland and from Bioferme Ltd. and Raisio Group.

PII: S1525-8610(09)00085-1

doi: 10.1016/j.jamda.2009.02.007

JAMDA
Volume 10, Issue 5 , Pages 348-353 , June 2009