« Previous
Next »
JAMDA
Volume 10, Issue 9
, Pages 607-616
, November 2009
Erythropoiesis-Stimulating Agents in Anemia: Use and Misuse
References
- . Erythropoiesis-stimulating agents in anemia. Geriatrics. 2008;63:13–29
- KDOQI Clinical Practice Guideline and Clinical Practice Recommendations for anemia in chronic kidney disease: 2007 update of hemoglobin target. Am J Kidney Dis. 2007;50:471–530
- . Clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease in adults. Am J Kidney Dis. 2006;47:S16–S85
- . Erythropoietin: From bench to bedside. Nephrology Rounds. 2004;2:1–6
- . Anemia in chronic kidney disease: Causes, diagnosis, treatment. Cleve Clin J Med. 2006;73:289–297
- . Practical approach to the diagnosis and treatment of anemia associated with CKD in elderly. J Am Med Dir Assoc. 2006;7:S7–S12quiz S17–21
- . Erythropoietin: Physiology and pharmacology update. Exp Biol Med (Maywood). 2003;228:1–14
- . Studies on the mechanism of erythropoietic stimulation in parabiotic rats during hypoxia. Blood. 1950;5:372–380
- . Studies on the production of erythropoietin by isolated perfused organs. Blood. 1961;18:527–534
- Cloning and expression of the human erythropoietin gene. Proc Natl Acad Sci U S A. 1985;82:7580–7584
- Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature. 1985;313:806–810
- Treatment of the anemia of progressive renal failure with recombinant human erythropoietin. N Engl J Med. 1989;321:158–163
- . Development and characterization of novel erythropoiesis stimulating protein (NESP). Br J Cancer. 2001;84:3–10
- . Biology of erythropoietin. Haematologica. 1998;83:724–732
- Localization of cells producing erythropoietin in murine liver by in situ hybridization. Blood. 1991;77:2497–2503
- . In vivo and in vitro regulation of erythropoietin mRNA: Measurement by competitive polymerase chain reaction. Blood. 1993;81:617–623
- . Organ distribution of erythropoietin messenger RNA in normal and uremic rats. Kidney Int. 1991;40:69–76
- A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes. J Biol Chem. 1994;269:19488–19493
- . Regulation of erythropoietin production. Eur J Clin Invest. 2005;35:13–19
- . Erythropoiesis, erythropoietin, and iron. Blood. 1982;60:1241–1246
- Information on Erythropoiesis Stimulating Agents (ESA) (marketed as Procrit, Epogen, and Aranesp). Information for Healthcare Professionals. Available at: http://www.fda.gov/cder/drug/InfoSheets/HCP/RHE200711HCP.htm. Accessed December 28, 2008.
- . Why is erythropoietin made in the kidney? The kidney functions as a critmeter. Am J Kidney Dis. 2001;38:415–425
- . The erythropoietin receptor of rat erythroid progenitor lens. Characterization and affinity cross-linkage. J Biol Chem. 1987;262:13985–13990
- . Erythropoietins: A common mechanism of action. Exp Hematol. 2008;36:1573–1584
- Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proc Natl Acad Sci U S A. 1996;93:9126–9131
- . The prolactin receptor and severely truncated erythropoietin receptors support differentiation of erythroid progenitors. J Biol Chem. 1997;272:14009–14012
- Erythropoietin can promote erythroid progenitor survival by repressing apoptosis through Bcl-XL and Bcl-2. Blood. 1996;88:1576–1582
- . New avenues of exploration for erythropoietin. JAMA. 2005;293:90–95
- . Angiogenesis and plasticity: role of erythropoietin in vascular systems. J Hematother Stem Cell Res. 2002;11:863–871
- Prevalence of anemia in persons 65 years and older in the United States: Evidence for a high rate of unexplained anemia. Blood. 2004;104:2263–2268
- . Anemia in the elderly: How should we define it, when does it matter, and what can be done?. Mayo Clin Proc. 2007;82:958–966
- . Mild anemia and the risk of falls in older adults from nursing homes and the community. J Am Med Dir Assoc. 2004;5:395–400
- . Anemia increases risk for falls in hospitalized older adults: An evaluation of falls in 362 hospitalized, ambulatory, long-term care, and community patients. J Am Med Dir Assoc. 2007;8:e9–e15
- Risk of Alzheimer's disease among elderly patients with anemia: Population-based investigations in Olmsted County, Minnesota. Ann Epidemiol. 1997;7:219–224
- . Five-year survival of older people with anemia: Variation with hemoglobin concentration. J Am Geriatr Soc. 2001;49:1226–1228
- Impact of anemia on hospitalization and mortality in older adults. Blood. 2006;107:3841–3846
- Anemia: Its impact on hospitalizations and length of hospital stay in nursing home and community older adults. J Am Med Dir Assoc. 2008;9:354–359
- Chronic anemia and fatigue in elderly patients: Results of a randomized, double-blind, placebo-controlled, crossover exploratory study with epoetin alfa. J Am Geriatr Soc. 2007;55:1557–1565
- . Anemia and response to epoetin alfa: The cause of anemia matters!. J Am Geriatr Soc. 2008;56(8):1574–1575
- . Serum erythropoietin levels in the elderly. Gerontology. 1991;37:345–348
- Reduced erythropoietin secretion in senile anemia. Am J Hematol. 1992;41:252–257
- Serum erythropoietin levels in elderly inpatients with anemia of chronic disorders and iron deficiency anemia. J Am Geriatr Soc. 1993;41:1301–1304
- Recombinant human erythropoietin for chronic renal failure anaemia in pre-dialysis patients. Cochrane Database Syst Rev. 2001;(4):CD003266
- Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med. 2006;355:2071–2084
- Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med. 2006;355:2085–2098
- . The TREAT study answers a question, not the question. Am J Kidney Dis. 2008;52:626–627author reply 627–628
- . An ongoing study of anemia correction in chronic kidney disease. N Engl J Med. 2007;356:959–961
- Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: Randomised, double-blind, placebo-controlled trial. Lancet. 2003;362:1255–1260
- Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemotherapy: A survival study. J Clin Oncol. 2005;23:5960–5972
- Randomized, double-blind, placebo-controlled trial of erythropoietin in non-small-cell lung cancer with disease-related anemia. J Clin Oncol. 2007;25:1027–1032
- . Weighing the hazards of erythropoiesis stimulation in patients with cancer. N Engl J Med. 2007;356:2445–2448
- . Cancer-related anemia: Special considerations in the elderly. Oncology (Williston Park). 2007;21:81–8690; discussion 90, 100,104
- Information on Erythropoiesis Stimulating Agents (ESA) (marketed as Procrit, Epogen and Aranesp). Prescribing information. Available at: http://www.fda.gov/cder/drug/infopage/RHE/default.htm. Accessed January 1, 2008, 2008.
- Erythropoietin with iron supplementation to prevent allogeneic blood transfusion in total hip joint arthroplasty. A randomized, controlled trial. Ann Intern Med. 2000;133:845–854
- . Autologous blood donation plus epoetin alfa in nonanemic orthopedic surgery patients. Semin Hematol. 1996;33:31–32discussion 33
- . Incidence of symptomatic venous thromboembolism after different elective or urgent surgical procedures. Thromb Haemost. 2003;90:446–455
- . Treatment for anemia in people with AIDS. Cochrane Database Syst Rev. 2007;(1):CD004776
- Serum erythropoietin levels in anaemic patients with advanced human immunodeficiency virus infection. Br J Haematol. 1992;82:608–614
- Pure red-cell aplasia and epoetin therapy. N Engl J Med. 2004;351:1403–1408
- . Use of erythropoiesis-stimulating agents in patients with anemia of chronic kidney disease: Overcoming the pharmacological and pharmacoeconomic limitations of existing therapies. Mayo Clin Proc. 2007;82:1371–1380
- . The diagnosis and management of anemia in chronic kidney disease in long term care. Long-term Care Interface. 2007;8:47–51
- . Epidemiology of anemia in the elderly: Information on diagnostic evaluation. J Am Geriatr Soc. 2003;51:S2–S9
- . Assessing iron status: Beyond serum ferritin and transferrin saturation. Clin J Am Soc Nephrol. 2006;1:S4–S8
- . Erythropoietin, iron, and erythropoiesis. Blood. 2000;96:823–833
- . Erythropoietin resistance: The role of inflammation and pro-inflammatory cytokines. Nephrol Dial Transplant. 2002;17:39–43
- . Regulation of iron metabolism by hepcidin. Annu Rev Nutr. 2006;26:323–342
- . Upper limit of serum ferritin: Misinterpretation of the 2006 KDOQI anemia guidelines. Semin Dial. 2008;21:217–220
- Are we giving too much iron? Low-dose iron therapy is effective in octogenarians. Am J Med. 2005;118:1142–1147
- . Iron deficiency and overload. Hematology Am Soc Hematol Educ Program. 2003;40–61
- . Hematologic disorder in older adults. In: Dharmarajan TS, Norman RA editor. Clinical Geriatrics. New York, NY: The Parthenon Publishing Group; 2003;p. 490
- . Stimulating erythropoiesis: Future perspectives. Kidney Blood Press Res. 2008;31:234–246
- . The first biosimilar epoetin: But how similar is it?. Clin J Am Soc Nephrol. 2008;3:174–178
- . Comparison of different dosing regimens (once weekly vs. twice weekly, and once weekly vs. once every two weeks) with epoetin delta in patients with chronic kidney disease: A randomized controlled trial. Trials. 2007;8:35
- . Methoxy polyethylene glycol-epoetin beta: A review of its use in the management of anaemia associated with chronic kidney disease. Drugs. 2008;68:1139–1156
- Once-monthly subcutaneous C.E.R.A. maintains stable hemoglobin control in patients with chronic kidney disease on dialysis and converted directly from epoetin one to three times weekly. Clin J Am Soc Nephrol. 2007;2:637–646
- C.E.R.A. corrects anemia in patients with chronic kidney disease not on dialysis: Results of a randomized clinical trial. Clin J Am Soc Nephrol. 2008;3:337–347
- Safety of ferumoxytol in patients with anemia and CKD. Am J Kidney Dis. 2008;52:907–915
- . Anemia: It's all about quality of life. J Am Med Dir Assoc. 2007;8:80–82
PII: S1525-8610(09)00176-5
doi: 10.1016/j.jamda.2009.05.003
© 2009 American Medical Directors Association. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
JAMDA
Volume 10, Issue 9
, Pages 607-616
, November 2009
