JAMDA
Volume 11, Issue 1 , Pages 33-41 , January 2010

Prevalence and Severity of Chronic Kidney Disease and Anemia in the Nursing Home Population

  • William M. McClellan, MD, MPH

      Affiliations

    • Department of Epidemiology, Emory University, Atlanta, GA
    • Corresponding Author InformationAddress correspondence to William M. McClellan, MD, MPH, Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd., Atlanta, GA 30322.
    • ,
  • Barbara Resnick, PhD

      Affiliations

    • University of Maryland School of Nursing, Baltimore, MD
    • ,
  • Lei Lei, PhD

      Affiliations

    • Department of Biostatistics & Epidemiology, Amgen, Inc., Thousand Oaks, CA
    • ,
  • Brian D. Bradbury, MA, DSc

      Affiliations

    • Department of Biostatistics & Epidemiology, Amgen, Inc., Thousand Oaks, CA
    • ,
  • Angela Sciarra, PharmD

      Affiliations

    • Department of Clinical Development, Amgen, Inc., Thousand Oaks, CA
    • ,
  • Reshma Kewalramani, MD

      Affiliations

    • Department of Clinical Development, Amgen, Inc., Thousand Oaks, CA
    • ,
  • Joseph G. Ouslander, MD

      Affiliations

    • Charles E. Schmidt College of Biomedical Science and Christine E. Lynn College of Nursing, Florida Atlantic University, Boca Raton, FL
    • Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL

References 

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  2. Fried LF, Lee JS, Shlipak M, et al. Chronic kidney disease and functional limitation in older people: health, aging and body composition study. J Am Geriatr Soc. 2006;54:750–756
  3. McFarlane SI, Chen SC, Whaley-Connell AT, et al. Prevalence and associations of anemia of CKD: Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES) 1999–2004. Am J Kidney Dis. 2008;51:S46–S55
  4. Joseph J, Koka M, Aronow WS. Prevalence of moderate and severe renal insufficiency in older persons with hypertension, diabetes mellitus, coronary artery disease, peripheral arterial disease, ischemic stroke, or congestive heart failure in an academic nursing home. J Am Med Dir Assoc. 2008;9:257–259
  5. Dukkipati R, Adler S, Mehrotra R. Cardiovascular implications of chronic kidney disease in older adults. Drugs Aging. 2008;25:241–253
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  8. Fried LF, Shlipak MG, Stehman-Breen C, et al. Kidney function predicts the rate of bone loss in older individuals: the Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2006;61:743–748
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  11. Kurella M, Chertow GM, Fried LF, et al. Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition study. J Am Soc Nephrol. 2005;16:2127–2133
  12. Lucca U, Tettamanti M, Mosconi P, et al. Association of mild anemia with cognitive, functional, mood and quality of life outcomes in the elderly: the “Health and Anemia” study. PLoS ONE. 2008;3:e1920
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  21. Levey AS, Coresh J, Balk E, et al. National Kidney Foundation practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Ann Intern Med. 2003;139:137–147
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  24. World Health Organization. 1994 Indicators and Strategies for Iron Deficiency and Anemia Programmes. Report of the WHO/UNICEF/UNU Consultation. Geneva, Switzerland.
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  27. Schnelle J, Osterweil D, Globe D, et al. Chronic kidney disease, anemia, and the association between chronic kidney disease-related anemia and activities of daily living in older nursing home residents. J Am Med Dir Assoc. 2009;10:120–126
  28. Robinson B, Artz AS, Culleton B, Critchlow C, Sciarra A, Audhya P. Prevalence of anemia in the nursing home: Contribution of chronic kidney disease. J Am Geriatr Soc. 2007;55:1566–1570
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  30. Ouseph R, Hendricks P, Hollon JA, et al. Under-recognition of chronic kidney disease in elderly outpatients. Clin Nephrol. 2007;68:373–378
  31. Quartarolo JM, Thoelke M, Schafers SJ. Reporting of estimated glomerular filtration rate: effect on physician recognition of chronic kidney disease and prescribing practices for elderly hospitalized patients. J Hosp Med. 2007;2:74–78
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  33. McCullough PA, Li S, Jurkovitz CT, et al. Chronic kidney disease, prevalence of premature cardiovascular disease, and relationship to short-term mortality. Am Heart J. 2008;156:277–283
  34. McClellan WM, Flanders WD, Langston RD, et al. Anemia and renal insufficiency are independent risk factors for death among patients with congestive heart failure admitted to community hospitals: A population-based study. J Am Soc Nephrol. 2002;13:1928–1936
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  37. Papaioannou A, Ray JG, Ferko NC, et al. Estimation of creatinine clearance in elderly persons in long-term care facilities. Am J Med. 2001;111:569–573
  38. Lamb EJ, Webb MC, Simpson DE, et al. Estimation of glomerular filtration rate in older patients with chronic renal insufficiency: Is the modification of diet in renal disease formula an improvement?. J Am Geriatr Soc. 2003;51:1012–1017
  39. Levey AS, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999;130:461–470
  40. Swedko PJ, Clark HD, Paramsothy K, Akbari A. Serum creatinine is an inadequate screening test for renal failure in elderly patients. Arch Intern Med. 2003;163:356–360
  41. Spruill WJ, Wade WE, Cobb HH. Comparison of estimated glomerular filtration rate with estimated creatinine clearance in the dosing of drugs requiring adjustments in elderly patients with declining renal function. Am J Geriatr Pharmacother. 2008;6:153–160

 B.D.B., L.L., A.S., and R.K. are employees of Amgen. J.G.O. served as a paid consultant to Amgen to help design and implement the project reported in this article, and has received an educational grant from Amgen.

PII: S1525-8610(09)00250-3

doi: 10.1016/j.jamda.2009.07.003

JAMDA
Volume 11, Issue 1 , Pages 33-41 , January 2010

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