JAMDA
Volume 11, Issue 3 , Pages 188-193 , March 2010

The Quantity of Meal Fat Influences the Profile of Postprandial Hormones as Well as Hunger Sensation in Healthy Elderly People

  • Vincenzo Di Francesco, MD

      Affiliations

    • Geriatric Unit, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    • Corresponding Author InformationAddress correspondence to Vincenzo Di Francesco, MD, PhD, Dipartimento Scienze Biomediche e Chirurgiche, Sezione di Geriatria, Ospedale Maggiore, p.le Stefani 1, 37126 Verona, Italy.
    • ,
  • Rocco Barazzoni, MD

      Affiliations

    • Clinica Medica, Department of Clinical, Morphological and Technological Sciences, University of Trieste, Italy
    • ,
  • Luisa Bissoli, MD

      Affiliations

    • Geriatric Unit, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    • ,
  • Francesco Fantin, MD

      Affiliations

    • Geriatric Unit, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    • ,
  • Paolo Rizzotti, MD

      Affiliations

    • Laboratorio di Analisi Chimico Cliniche ed Ematologiche, Azienda Ospedaliera di Verona, Verona, Italy
    • ,
  • Luigi Residori, MD

      Affiliations

    • Geriatric Unit, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    • ,
  • Angela Antonioli, MD

      Affiliations

    • Geriatric Unit, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    • ,
  • Maria Stella Graziani, PhD

      Affiliations

    • Laboratorio di Analisi Chimico Cliniche ed Ematologiche, Azienda Ospedaliera di Verona, Verona, Italy
    • ,
  • Michela Zanetti, MD

      Affiliations

    • Clinica Medica, Department of Clinical, Morphological and Technological Sciences, University of Trieste, Italy
    • ,
  • Ottavio Bosello, MD

      Affiliations

    • Geriatric Unit, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    • ,
  • Gianfranco Guarnieri, MD

      Affiliations

    • Clinica Medica, Department of Clinical, Morphological and Technological Sciences, University of Trieste, Italy
    • ,
  • Mauro Zamboni, MD

      Affiliations

    • Geriatric Unit, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy

References 

  1. Mowè M, Bohmer T, Kindt E. Reduced nutritional status in an elderly population (>70y) is probable before disease and possibly contributes to the development of disease. Am J Clin Nutr. 1994;59:317–324
  2. Morley JE. Anorexia of aging: Physiologic and pathologic. Am J Clin Nutr. 1997;66:760–773
  3. Roberts SB, Fuss P, Heyman MB, et al. Control of food intake in older men. JAMA. 1994;272:1601–1606
  4. Di Francesco V, Fantin F, Omizzolo F, et al. The anorexia of aging. Dig Dis. 2007;25:129–137
  5. Di Francesco V, Zamboni M, Dioli A, et al. Delayed postprandial gastric emptying and impaired gallbladder contraction together with elevated cholecystokinin and peptide YY serum levels sustain satiety and inhibit hunger in healthy elderly persons. J Gerontol A Biol Sci Med Sci. 2005;60:1581–1585
  6. MacIntosch GC, Andrews JM, Jones KL, et al. Effects of age on concentrations of plasma cholecystokinin, glucagon-like peptide 1 and peptide YY and their relation to appetite and pyloric motility. Am J Clin Nutr. 1999;69:999–1006
  7. MacIntosh CG, Morley JE, Wishart J, et al. Effects of exogenous cholecystokinin (CCK-8) on food intake and plasma CCK, leptin and insulin concentrations in older and young adults: Evidence for increased CCK activity as a cause of the anorexia of aging. J Clin Endocrinol Metab. 2001;86:5830–5837
  8. Di Francesco V, Zamboni M, Zoico E, et al. Unbalanced serum leptin and ghrelin dynamics prolong postprandial satiety and inhibit hunger in healthy elderly: Another reason for the “anorexia of aging”. Am J Clin Nutr. 2006;83:1149–1152
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  11. Cummings DE, Purnell JQ, Frayo RS, et al. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes. 2001;50:1714–1719
  12. Tolle V, Bassant MH, Zizzari P, et al. Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep-wake patterns in rats. Endocrinology. 2002;143:1353–1361
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  14. Asakawa A, Inui A, Fujimiya M, et al. Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin. Gut. 2005;54:18–24
  15. van der Lely AJ, Tschop M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev. 2004;25:426–457
  16. Akamizu T, Murayama T, Teramukai S, et al. Plasma ghrelin levels in healthy elderly volunteers: The levels of acylated ghrelin in elderly females correlate positively with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure. J Endocrinol. 2003;188:333–344
  17. Di Francesco V, Fantin F, Residori L, et al. Effect of age on the dynamics of acylated ghrelin in fasting conditions and in response to a meal. J Am Geriatr Soc. 2008;56:1369–1370
  18. Barazzoni R, Zanetti M, Ferreira C, et al. Relationships between desacylated and acylated ghrelin and insulin sensitivity in the metabolic syndrome. J Clin Endocrinol Metab. 2007;92:3935–3940
  19. de Graaf C, Blom WA, Smeets PA, et al. Biomarkers of satiation and satiety. Am J Clin Nutr. 2004;79:946–961
  20. Blundell JE, Cotton JR, Delargy H, et al. The fat-paradox: Fat-induced satiety signals versus high fat overconsumption. Int J Obes. 1995;19:832–835
  21. Cook CG, Andrews JM, Jones KL, et al. Effects of small intestinal nutrient infusion on appetite and pyloric motility are modified by age. Am J Physiol. 1997;273:R755–761
  22. Lim JE, Brubaker PL. Glucagon like peptide 1 secretion by the L-cell: The view from within. Diabetes. 2006;55:S70–S77
  23. Baggio LL, Drucker DJ. Biology of incretins. GLP-1 and GIP. Gastroenterology. 2007;132:2131–2157
  24. Niswender KD, Schwartz MW. Insulin and leptin revisited: Adiposity signals with overlapping physiological and intracellular signalling capabilities. Front Neuroendocrinol. 2003;241:1–10
  25. Williams DL, Baskin DG, Schwartz MW. Leptin regulation of the anorexic response to gucagon-like peptide-1 receptor stimulation. Diabetes. 2006;55:3387–3393

 This work was funded by grants from the University of Verona.

PII: S1525-8610(09)00276-X

doi: 10.1016/j.jamda.2009.08.004

JAMDA
Volume 11, Issue 3 , Pages 188-193 , March 2010

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