JAMDA
Volume 11, Issue 3 , Pages 179-187 , March 2010

Efficacy and Costs of Nutritional Rehabilitation in Muscle-Wasted Patients With Chronic Obstructive Pulmonary Disease in a Community-Based Setting: A Prespecified Subgroup Analysis of the INTERCOM Trial

  • Carel R. van Wetering

      Affiliations

    • Department of Respiratory Medicine, Máxima Medical Centre, Veldhoven, The Netherlands
    • ,
  • Martine Hoogendoorn, MSc

      Affiliations

    • Institute for Medical Technology Assessment (iMTA), Erasmus University/Erasmus Medical Centre, Rotterdam, The Netherlands
    • ,
  • Roelinka Broekhuizen, PhD

      Affiliations

    • Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    • ,
  • Gonnie J.W. Geraerts-Keeris

      Affiliations

    • Department of Dietetics, Máxima Medical Centre, Veldhoven, The Netherlands
    • ,
  • Dirk R.A.J. De Munck, MD

      Affiliations

    • Department of Respiratory Medicine, Máxima Medical Centre, Veldhoven, The Netherlands
    • ,
  • Maureen P.M.H. Rutten-van Mölken, PhD

      Affiliations

    • Institute for Medical Technology Assessment (iMTA), Erasmus University/Erasmus Medical Centre, Rotterdam, The Netherlands
    • ,
  • Annemie M.W.J. Schols, PhD

      Affiliations

    • Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    • Corresponding Author InformationAddress correspondence to Annemie Schols, PhD, Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands.

References 

  1. Ferreira I, Brooks D, Lacasse Y, et al. Nutritional supplementation for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2005;(2):CD000998
  2. Weekes CE, Emery PW, Elia M. Dietary counselling and food fortification in stable COPD: A randomised trial. Thorax. 2009;64:326–331
  3. Schols AM, Soeters PB, Mostert R, et al. Physiologic effects of nutritional support and anabolic steroids in patients with chronic obstructive pulmonary disease. A placebo-controlled randomized trial. Am J Respir Crit Care Med. 1995;152:1268–1274
  4. Steiner MC, Barton RL, Singh SJ, Morgan MD. Nutritional enhancement of exercise performance in chronic obstructive pulmonary disease: A randomised controlled trial. Thorax. 2003;58:745–751
  5. Broekhuizen R, Wouters EF, Creutzberg EC, et al. Polyunsaturated fatty acids improve exercise capacity in chronic obstructive pulmonary disease. Thorax. 2005;60:376–382
  6. Wetering CR, Hoogendoorn M, Mol SJ, et al. Short- and long-term efficacy of a community-based COPD management program in less advanced COPD: a randomised controlled trial. Thorax. 2010;65:7–13
  7. Hoogendoorn M, Wetering CR, Schols AM, et al. Is INTERdisicplinary COMmunity-based COPD management (INTERCOM) cost-effective?. Eur Respir J. 2010;35:79–87
  8. Jones NL, Makrides L, Hitchcock C, et al. Normal standards for an incremental progressive cycle ergometer test. Am Rev Respir Dis. 1985;131:700–708
  9. Vermeeren MA, Creutzberg EC, Schols AM, et al. Prevalence of nutritional depletion in a large out-patient population of patients with COPD; COSMIC Study Group. Respir Med. 2006;100:1349–1355
  10. Creutzberg EC, Wouters EF, Mostert R, et al. Efficacy of nutritional supplementation therapy in depleted patients with chronic obstructive pulmonary disease. Nutrition. 2003;19:120–127
  11. Creutzberg EC, Schols AM, Weling-Scheepers , et al. Characterization of nonresponse to high caloric oral nutritional therapy in depleted patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000;161:745–752
  12. Engelen MP, Rutten EP, De Castro CL, et al. Supplementation of soy protein with branched-chain amino acids alters protein metabolism in healthy elderly and even more in patients with chronic obstructive pulmonary disease. Am J Clin Nutr. 2007;85:431–439
  13. Gosker HR, Zeegers M, Wouters FM, Schols AMWJ. Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: A systematic review and meta-analysis. Thorax. 2007;62:944–949
  14. Decramer M, Gosselink R, Troosters T, et al. Muscle weakness is related to utilization of health care resources in COPD patients. Eur Respir J. 1997;10:417–423
  15. Van Wetering CR, Van Nooten FE, Mol SJM, et al. Systemic impairment in relation to disease burden in patients with moderate COPD eligible for a lifestyle program. Int J Chron Obstruct Pulmon Dis. 2008;3:443–451

 Funding for this study was provided by the Netherlands government: Clinical Trial registration number: NCT00840892. This study was financially supported by the Netherlands Asthma Foundation (NAF, 3.4.01.63), the "Stichting Astma Bestrijding" (SAB), Nutricia Netherlands, Pfizer and Partners in Care Solutions (PICASSO) for COPD.

PII: S1525-8610(09)00519-2

doi: 10.1016/j.jamda.2009.12.083

JAMDA
Volume 11, Issue 3 , Pages 179-187 , March 2010

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