JAMDA
Volume 11, Issue 7 , Pages 457-458 , September 2010

The Paradigm of Life Extension

  • Ligia J. Dominguez, MD

      Affiliations

    • Geriatric Unit, Department of Clinical Medicine and Emerging Pathologies, University of Palermo, Italy
    • Corresponding Author InformationAddress correspondence to Ligia J. Dominguez, MD, Geriatric Unit, Department of Clinical Medicine and Emerging Pathologies, University of Palermo, viale F. Scaduto 6/c, 90144 Palermo Italy.
    • ,
  • Mario Barbagallo, MD

      Affiliations

    • Geriatric Unit, Department of Clinical Medicine and Emerging Pathologies, University of Palermo, Italy
    • ,
  • John E. Morley, MB, BCh

      Affiliations

    • Geriatric Research, Education and Clinical Center, St. Louis VA Medical Center, and Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO

References 

  1. Christensen K, Doblhammer G, Rau R, Vaupel JW. Ageing populations: The challenges ahead. Lancet. 2009;374:1196–1208
  2. Fuller-Thomson E, Yu B, Nuru-Jeter A, et al. Basic ADL disability and functional limitations rates among older Americans from 2000–2005: The end of the decline?. J Gerontol A Biol Sci Med Sci. 2009;64:1333–1336
  3. Stewart ST, Cutler DM, Rosen AB. Forecasting the effects of obesity and smoking on US life expectancy. N Engl J Med. 2009;361:2252–2260
  4. Narasimhan SD, Yen K, Tissenbaum HA. Converging pathways in lifespan regulation. Curr Biol. 2009;19:R657–R666
  5. Williamson J, Pahor M. Evidence regarding the benefits of physical exercise. Arch Intern Med. 2010;170:124–125
  6. Sofi F, Cesari F, Abbate R, et al. Adherence to Mediterranean diet and health status: Meta-analysis. BMJ. 2008;337:a1344
  7. Dominguez LJ, Barbagallo M, Morley JE. Anti-aging medicine: Pitfalls and hopes. Aging Male. 2009;12:13–20
  8. Morley JE. Vitamin D redux. J Am Med Dir Assoc. 2009;10:591–592
  9. Wang C, Nieschlag E, Swerdloff R, et al. Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations. Eur J Endocrinol. 2008;159:507–514
  10. Morley JE, Chahla E, Alkaade S. Antiaging, longevity and calorie restriction. Curr Opin Clin Nutr Metab Care. 2010;13:40–45
  11. Morley JE. Weight loss in older persons: New therapeutic approaches. Curr Pharm Des. 2007;13:3637–3647
  12. Morley JE. Developing novel therapeutic approaches to frailty. Curr Pharm Des. 2009;15:3384–3395
  13. Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature. 2008;451:1069–1075
  14. Song H, Song BW, Cha MJ, et al. Modification of mesenchymal stem cells for cardiac regeneration. Expert Opin Biol Ther. 2010;10:309–319
  15. Long JL, Neubauer J, Zhang Z, et al. Functional testing of a tissue-engineered vocal fold cover replacement. Otolaryngol Head Neck Surg. 2010;142:438–440
  16. Djouad F, Bouffi C, Ghannam S, et al. Mesenchymal stem cells: Innovative therapeutic tools for rheumatic diseases. Nat Rev Rheumatol. 2009;5:392–399
  17. Darviri C, Demakakos P, Tigani X, et al. Psychosocial dimensions of exceptional longevity: A qualitative exploration of centenarians' experiences, personality, and life strategies. Int J Aging Hum Dev. 2009;69:101–118
  18. Young Y, Fan MY, Parrish JM, Frick KD. Validation of a novel successful aging construct. J Am Med Dir Assoc. 2009;10:314–322
  19. Young Y, Frick KD, Phelan EA. Can successful aging and chronic illness coexist in the same individual? A multidimensional concept of successful aging. J Am Med Dir Assoc. 2009;10:87–92
  20. Morley JE. Successful aging or aging successfully. J Am Med Dir Assoc. 2009;10:85–86
  21. Morley JE. The magic of exercise. J Am Med Dir Assoc. 2008;9:375–377

 Dr. Dominguez has no conflict of interest. Dr. Morley acknowledges affiliations with Mattern Pharmaceuticals, Edunn Biotech, and Danone.

PII: S1525-8610(10)00185-4

doi: 10.1016/j.jamda.2010.05.009

JAMDA
Volume 11, Issue 7 , Pages 457-458 , September 2010

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