JAMDA
Volume 13, Issue 2 , Pages 96-99 , February 2012

Geriatric Conditions and Adverse Drug Reactions in Elderly Hospitalized Patients

  • Fabrizia Lattanzio, MD, PhD

      Affiliations

    • Scientific Direction, Italian National Research Center on Aging (INRCA), Ancona, Italy
    • ,
  • Irma Laino, MD

      Affiliations

    • Unit of Geriatric Pharmacoepidemiology, INRCA, Cosenza, Italy
    • Corresponding Author InformationAddress correspondence to Irma Laino, MD, Unità di Farmacoepidemiologia Geriatrica, Istituto Nazionale di Ricovero e Cura per Anziani (INRCA), C.da Muoio Piccolo, I-87100 Cosenza, Italy.
    • ,
  • Claudio Pedone, MD, PhD

      Affiliations

    • Geriatric Medicine, University Campus Biomedico, Rome, Italy
    • Alberto Sordi Foundation, Rome, Italy
    • ,
  • Francesco Corica, MD

      Affiliations

    • Department of Internal Medicine, University of Messina, Messina, Italy
    • ,
  • Giuseppe Maltese, MD, PhD

      Affiliations

    • Unit of Metabolic Medicine, Cardiovascular Division, King’s College London, London, United Kingdom
    • ,
  • Giovanni Salerno, HN

      Affiliations

    • Unit of Geriatric Medicine, INRCA, Cosenza, Italy
    • ,
  • Sabrina Garasto, ScD

      Affiliations

    • Unit of Geriatric Pharmacoepidemiology, INRCA, Cosenza, Italy
    • ,
  • Andrea Corsonello, MD

      Affiliations

    • Unit of Geriatric Pharmacoepidemiology, INRCA, Cosenza, Italy
    • ,
  • Raffaele Antonelli Incalzi, MD

      Affiliations

    • Geriatric Medicine, University Campus Biomedico, Rome, Italy
    • San Raffaele Foundation, Cittadella della Carità, Taranto, Italy
    • ,
  • PharmacosurVeillance in the elderly Care (PVC) Study Group

References 

  1. Hartholt KA, van der Velde N, Looman CW, et al. Adverse drug reactions related hospital admissions in persons aged 60 years and over, The Netherlands, 1981-2007: less rapid increase, different drugs. PLoS One. 2010;5:e13977
  2. Corsonello A, Pedone C, Incalzi RA. Age-related pharmacokinetic and pharmacodynamic changes and related risk of adverse drug reactions. Curr Med Chem. 2010;17:571–584
  3. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146–M156
  4. Cohen HJ, Feussner JR, Weinberger M, et al. A controlled trial of inpatient and outpatient geriatric evaluation and management. N Engl J Med. 2002;346:905–912
  5. Corsonello A, Pedone C, Corica F, et al. Concealed renal insufficiency and adverse drug reactions in elderly hospitalized patients. Arch Intern Med. 2005;165:790–795
  6. Onder G, Petrovic M, Tangiisuran B, et al. Development and validation of a score to assess risk of adverse drug reactions among in-hospital patients 65 years or older: the GerontoNet ADR risk score. Arch Intern Med. 2010;170:1142–1148
  7. Steinman MA, Hanlon JT, Sloane RJ, et al. Do geriatric conditions increase risk of adverse drug reactions in ambulatory elders? Results From the VA GEM Drug Study. J Gerontol A Biol Sci Med Sci. 2011;66:444–451
  8. Suh DC, Manning WG, Schondelmeyer S, et al. Effect of multiple-source entry on price competition after patent expiration in the pharmaceutical industry. Health Serv Res. 2000;35:529–547
  9. Corsonello A, Pedone C, Lattanzio F, et al. Potentially inappropriate medications and functional decline in elderly hospitalized patients. J Am Geriatr Soc. 2009;57:1007–1014
  10. Sanchez Munoz-Torrero JF, Barquilla P, Velasco R, et al. Adverse drug reactions in internal medicine units and associated risk factors. Eur J Clin Pharmacol 66:1257–1264.
  11. World Health Organization. International Drug Monitoring: The Role of the Hospital. Geneva, Switzerland: World Health Organization; 1969;WHO Technical Report Series No. 425
  12. Lesher EL, Berryhill JS. Validation of the Geriatric Depression Scale–Short Form among inpatients. J Clin Psychol. 1994;50:256–260
  13. Conwell Y, Forbes NT, Cox C, et al. Validation of a measure of physical illness burden at autopsy: the Cumulative Illness Rating Scale. J Am Geriatr Soc. 1993;41:38–41
  14. Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150:604–612
  15. De Breucker S, Herzog G, Pepersack T. Could geriatric characteristics explain the under-prescription of anticoagulation therapy for older patients admitted with atrial fibrillation? A retrospective observational study. Drugs Aging. 2010;27:807–813
  16. Williams FM, Wynne H, Woodhouse KW, et al. Plasma aspirin esterase: the influence of old age and frailty. Age Ageing. 1989;18:39–42
  17. Wynne HA, Cope LH, Herd B, et al. The association of age and frailty with paracetamol conjugation in man. Age Ageing. 1990;19:419–424
  18. Woolcott JC, Richardson KJ, Wiens MO, et al. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med. 2009;169:1952–1960

 The PharmacosurVeillance in the elderly Care (PVC) study was partially supported by a grant from the Italian Ministry of Health (RF-INR-2005-127640).

PII: S1525-8610(11)00116-2

doi: 10.1016/j.jamda.2011.04.006

JAMDA
Volume 13, Issue 2 , Pages 96-99 , February 2012

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