Abstract
Objectives
Mild cognitive impairment (MCI) may be a risk for disability, and co-occurrence of
slow gait (SG) and MCI may increase this risk.
Design
Prospective study.
Setting
General community.
Participants
The study included 3482 older adults (mean age: 71.4 years) without disability at
baseline.
Measurements
We collected information on demographic variables, measured gait speed and cognitive
function to diagnose MCI at baseline. During the follow-up period, the incident disability
was monitored. Participants were divided into groups without MCI and SG (control),
with SG without MCI (SG), without SG and with MCI in single (sMCI) or multiple (mMCI)
domains, and with SG and MCI in single (sMCI + SG) and multiple (mMCI + SG) domains.
Results
During follow-up, 134 participants developed disability (mean follow-up: 29.4 months).
The proportions of incident disability were higher in the MCI with SG, MCI, and SG
groups, compared with the control group. SG [hazard ratio 2.27 (95% confidence interval:
1.38–3.73)], mMCI [2.56 (1.31–5.02)], sMCI + SG [2.46 (1.21–5.00)], and mMCI + SG
[3.48 (1.79–6.76)] participants had risks for disability.
Conclusions
Co-occurrence of SG and MCI in multiple domains has a higher risk of disability than
each condition alone.
Keywords
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Article info
Publication history
Published online: August 19, 2015
Footnotes
This work was supported by Health and Labor Sciences Research Grants (Comprehensive Research on Aging and Health); a Grant-in-Aid for Scientific Research (B) (grant number 23300205); a Grant-in-Aid for Young Scientists (A) (grant number 15H05369) and Research Funding for Longevity Sciences (22-16).
The authors declare no conflicts of interest.
Identification
Copyright
© 2015 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.
