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Original Study| Volume 16, ISSUE 12, P1082-1086, December 01, 2015

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Mild Cognitive Impairment, Slow Gait, and Risk of Disability: A Prospective Study

Published:August 19, 2015DOI:https://doi.org/10.1016/j.jamda.2015.07.007

      Abstract

      Objectives

      Mild cognitive impairment (MCI) may be a risk for disability, and co-occurrence of slow gait (SG) and MCI may increase this risk.

      Design

      Prospective study.

      Setting

      General community.

      Participants

      The study included 3482 older adults (mean age: 71.4 years) without disability at baseline.

      Measurements

      We collected information on demographic variables, measured gait speed and cognitive function to diagnose MCI at baseline. During the follow-up period, the incident disability was monitored. Participants were divided into groups without MCI and SG (control), with SG without MCI (SG), without SG and with MCI in single (sMCI) or multiple (mMCI) domains, and with SG and MCI in single (sMCI + SG) and multiple (mMCI + SG) domains.

      Results

      During follow-up, 134 participants developed disability (mean follow-up: 29.4 months). The proportions of incident disability were higher in the MCI with SG, MCI, and SG groups, compared with the control group. SG [hazard ratio 2.27 (95% confidence interval: 1.38–3.73)], mMCI [2.56 (1.31–5.02)], sMCI + SG [2.46 (1.21–5.00)], and mMCI + SG [3.48 (1.79–6.76)] participants had risks for disability.

      Conclusions

      Co-occurrence of SG and MCI in multiple domains has a higher risk of disability than each condition alone.

      Keywords

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