Abstract
Objectives
Motoric cognitive syndrome (MCR), a newly described predementia syndrome characterized
by cognitive complaints and slow gait, is associated with increased risk of developing
dementia. Due to the potential differences in health, behavioral, and lifestyle factors
between races that can influence dementia risk, it is important to examine risk factors
for MCR in different countries. This study aimed to report the prevalence as well
as modifiable factors associated with MCR in Japanese community-dwelling older adults.
Design
A cross-sectional design.
Setting
General community.
Participants
A total of 9683 older adults (52% women, mean age: 73.6 years) participating in the
National Center for Geriatrics and Gerontology Study of Geriatric Syndromes.
Measurements
Participants were screened for presence of MCR at baseline. The association of selected
modifiable risk factors (medical illness, depressive symptoms, and falls) and lifestyle
variables (obesity, physical inactivity, smoking, and alcohol consumption) with MCR
was examined using multivariate logistic regression analysis.
Results
At cross-section, 619 participants met criteria for MCR, with an overall prevalence
6.4% (95% CI 5.9–6.9). A higher prevalence of MCR was seen with advancing age (P < .001), but there were no sex differences. Diabetes (adjusted odds ratio [OR] 1.47,
P = .001), depressive symptoms (OR 3.57, P < .001), and falls (OR 1.45, P < .001) were associated with increased risk of MCR. Among the lifestyle factors,
obesity (OR 1.26, P = .018) and physical inactivity (OR 1.57, P < .001) were associated with increased risk of MCR.
Conclusion
MCR is common in the elderly Japanese population. The potentially modifiable risk
and lifestyle factors identified for MCR should be further studied to develop interventions.
Keywords
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Article info
Publication history
Published online: October 14, 2015
Footnotes
The authors declare no conflicts of interest.
This study was funded by Health and Labour Sciences Research grants (Comprehensive Research on Aging and Health); Grant-in-Aid for JSPS Fellows (259435); Grant-in-Aid for Scientific Research (B) (grant number 23300205); Grant-in-Aid for Young Scientists (A) (15H05369), and Research Funding for Longevity Sciences (22–16) from the National Center for Geriatrics and Gerontology, Japan.
Identification
Copyright
© 2015 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.
