Advertisement

Association Between Accumulation of Advanced Glycation End-Products and Hearing Impairment in Community-Dwelling Older People: A Cross-Sectional Sukagawa Study

Published:October 24, 2017DOI:https://doi.org/10.1016/j.jamda.2017.09.008

      Abstract

      Objectives

      The experimental studies suggested the hypothesis that the accumulation of advanced glycation end-products (AGEs) could induce hearing impairment. The purpose of this study is to examine the hypothesis among elderly people using an epidemiologic approach.

      Design

      Cross-sectional study.

      Setting

      Sukagawa City, Fukushima, Japan.

      Participants

      A total of 270 residents aged 75 years or over without dementia, who participated in a health check-up conducted in 2015.

      Measurements

      The exposure variable was AGEs, which was assessed using skin autofluorescence (AF) as a proxy measure. The primary outcome was moderate hearing impairment or worse, which was defined as a pure tone average of thresholds ≥41 decibel hearing level at 0.5, 1, 2, and 4 kHz in the better-hearing ear. The secondary outcome was the pure tone average of thresholds as a continuous variable. We estimated the odds ratio using a logistic regression model for the primary outcome and a general linear model for the mean difference in the pure tone average of thresholds for the secondary outcome. Both models were adjusted for relevant confounding factors: age, sex, smoking, diabetes, hypertension, and history of cerebrovascular diseases.

      Results

      The median (interquartile range) AF was 2.2 (2.0, 2.5) arbitrary units (AU). Moderate hearing impairment was reported in 88 participants (32.6%). For the primary outcome, we found significant associations between moderate hearing impairment and AF (adjusted odds ratio per 1 AU, 2.60; 95% confidence interval 1.26–5.35). For the secondary outcome, we also found a significant association between a 1-AU increase in AF and increased pure tone average, with a difference (6.52 dB per 1 AU; 95% confidence interval 2.18–10.86) comparable in magnitude to the increase in pure tone average observed for a 6-year increase in age in our population.

      Conclusions

      Our study indicated that high levels of AGEs were independently associated with hearing impairment. Modifying levels of AGEs may prevent hearing impairment.

      Keywords

      To read this article in full you will need to make a payment

      Subscribe:

      Subscribe to Journal of the American Medical Directors Association
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Jiam N.T.
        • Li C.
        • Agrawal Y.
        Hearing loss and falls: A systematic review and meta-analysis.
        Laryngoscope. 2016; 126: 2587-2596
        • Mener D.J.
        • Betz J.
        • Genther D.J.
        • et al.
        Hearing loss and depression in older adults.
        J Am Geriatr Soc. 2013; 61: 1627-1629
        • Hung S.C.
        • Liao K.F.
        • Muo C.H.
        • et al.
        Hearing Loss is Associated With Risk of Alzheimer's Disease: A Case-Control Study in Older People.
        J Epidemiol. 2015; 25: 517-521
        • Schmulian Taljaard D.
        • Olaithe M.
        • Brennan-Jones C.G.
        • et al.
        The relationship between hearing impairment and cognitive function: A meta-analysis in adults.
        Clin Otolaryngol. 2016; 41: 718-729
        • Genther D.J.
        • Betz J.
        • Pratt S.
        • et al.
        Association of hearing impairment and mortality in older adults.
        J Gerontol A Biol Sci Med Sci. 2015; 70: 85-90
        • Contrera K.J.
        • Betz J.
        • Genther D.J.
        • Lin F.R.
        Association of Hearing Impairment and Mortality in the National Health and Nutrition Examination Survey.
        JAMA Otolaryngol Head Neck Surg. 2015; 141: 944-946
        • Karpa M.J.
        • Gopinath B.
        • Beath K.
        • et al.
        Associations between hearing impairment and mortality risk in older persons: The Blue Mountains Hearing Study.
        Ann Epidemiol. 2010; 20: 452-459
        • Uchida Y.
        • Sugiura S.
        • Nakashima T.
        • et al.
        Nihon Ronen Igakkai Zasshi. 2012; 49: 222-227
        • Yamasoba T.
        • Lin F.R.
        • Someya S.
        • et al.
        Current concepts in age-related hearing loss: Epidemiology and mechanistic pathways.
        Hear Res. 2013; 303: 30-38
        • Ahmad M.S.
        • Damanhouri Z.A.
        • Kimhofer T.
        • et al.
        A new gender-specific model for skin autofluorescence risk stratification.
        Sci Rep. 2015; 5: 10198
        • Nicholl I.D.
        • Bucala R.
        Advanced glycation endproducts and cigarette smoking.
        Cell Mol Biol (Noisy-le-grand). 1998; 44: 1025-1033
        • Koschinsky T.
        • He C.J.
        • Mitsuhashi T.
        • et al.
        Orally absorbed reactive glycation products (glycotoxins): An environmental risk factor in diabetic nephropathy.
        Proc Natl Acad Sci U S A. 1997; 94: 6474-6479
        • Sánchez-Rodríguez C.
        • Martín-Sanz E.
        • Cuadrado E.
        • et al.
        Protective effect of polyphenols on presbycusis via oxidative/nitrosative stress suppression in rats.
        Exp Gerontol. 2016; 83: 31-36
        • Lazo M.
        • Halushka M.K.
        • Shen L.
        • et al.
        Soluble receptor for advanced glycation end products and the risk for incident heart failure: The Atherosclerosis Risk in Communities Study.
        Am Heart J. 2015; 170: 961-967
        • Schmidt A.M.
        • Yan S.D.
        • Wautier J.L.
        • Stern D.
        Activation of receptor for advanced glycation end products: A mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis.
        Circ Res. 1999; 84: 489-497
        • Hanusek C.
        • Setz C.
        • Radojevic V.
        • et al.
        Expression of advanced glycation end-product receptors in the cochlea.
        Laryngoscope. 2010; 120: 1227-1232
        • Xing Y.
        • Ji Q.
        • Li X.
        • et al.
        Asiaticoside protects cochlear hair cells from high glucose-induced oxidative stress via suppressing AGEs/RAGE/NF-κB pathway.
        Biomed Pharmacother. 2017; 86: 531-536
        • Tsutsui T.
        • Muramatsu N.
        Care-needs certification in the long-term care insurance system of Japan.
        J Am Geriatr Soc. 2005; 53: 522-527
        • Yue X.
        • Hu H.
        • Koetsier M.
        • et al.
        Reference values for the Chinese population of skin autofluorescence as a marker of advanced glycation end products accumulated in tissue.
        Diabet Med. 2011; 28: 818-823
        • Hangai M.
        • Takebe N.
        • Honma H.
        • et al.
        Association of advanced glycation end products with coronary artery calcification in Japanese subjects with type 2 diabetes as assessed by skin autofluorescence.
        J Atheroscler Thromb. 2016; 23: 1178-1187
      1. WHO Grades of hearing impairment (online). Available at: http://www.who.int/pbd/deafness/hearing_impairment_grades/en. Accessed November 24, 2016.

        • Lutgers H.L.
        • Graaff R.
        • Links T.P.
        • et al.
        Skin autofluorescence as a noninvasive marker of vascular damage in patients with type 2 diabetes.
        Diabetes Care. 2006; 29: 2654-2659
        • Meerwaldt R.
        • Lutgers H.L.
        • Links T.P.
        • et al.
        Skin autofluorescence is a strong predictor of cardiac mortality in diabetes.
        Diabetes Care. 2007; 30: 107-112
        • Macías-Cervantes M.H.
        • Rodríguez-Soto J.M.D.
        • Uribarri J.
        • et al.
        Effect of an advanced glycation end product-restricted diet and exercise on metabolic parameters in adult overweight men.
        Nutrition. 2015; 31: 446-451
        • Yoshikawa T.
        • Miyazaki A.
        • Fujimoto S.
        Decrease in serum levels of advanced glycation end-products by short-term lifestyle modification in non-diabetic middle-aged females.
        Med Sci Monit. 2009; 15: PH65-PH73
        • Nagai R.
        • Mori T.
        • Yamamoto Y.
        • et al.
        Significance of Advanced Glycation End Products in Aging-Related Disease.
        Anti Aging Med. 2010; 7: 112-119
        • Meerwaldt R.
        • Graaff R.
        • Oomen P.H.N.
        • et al.
        Simple noninvasive assessment of advanced glycation end product accumulation.
        Diabetologia. 2004; 47: 1324-1330
        • Fraser S.D.S.
        • Roderick P.J.
        • McIntyre N.J.
        • et al.
        Skin autofluorescence and all-cause mortality in stage 3 CKD.
        Clin J Am Soc Nephrol. 2014; 9: 1361-1368
        • Sasaki N.
        • Fukatsu R.
        • Tsuzuki K.
        • et al.
        Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases.
        Am J Pathol. 1998; 153: 1149-1155