Although a decade has passed since the elegant theory of “inflammaging” was proposed,
1
the precise pathophysiological pathways that lead to frailty, as opposed to “healthy”
aging, remain elusive. Elevated inflammatory markers have been associated with frailty
in cross-sectional studies of older adults.
2
A leading hypothesis is that persistent low-grade inflammation causes frailty via
catabolic effects of proinflammatory cytokines on muscle.
3
The inflammatory milieu is also thought to influence the progression of age-related
diseases, which in turn contribute to the development of frailty.
4
However, longitudinal data regarding inflammation and frailty are limited, and studies
have so far generated inconsistent results.
2
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the American Medical Directors AssociationAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans.Mech Ageing Dev. 2007; 128: 92-105
- Inflammation and frailty in the elderly: A systematic review and meta-analysis,.Ageing Res Rev. 2016; 31: 1-8
- Frailty, inflammation and the elderly.Biogerontology. 2010; 11: 635-941
- Aging, frailty and age-related diseases.Biogerontology. 2010; 11: 547-563
- The relationship between the dietary inflammatory index and incident frailty: A longitudinal cohort study.J Am Med Dir Assoc. 2017; 19: 77-82
- Mediterranean diet and inflammaging within the hormesis paradigm.Nutr Rev. 2017; 75: 442-455
- Sex differences in fruit and vegetable intake in older adults.Appetite. 2003; 40: 269-275
- Health and well-being in old age: The pertinence of a gender mainstreaming approach in research,.Gerontology. 2010; 56: 208-213
- Inflammatory markers and incident frailty in men and women: The English Longitudinal Study of Ageing.Age. 2013; 35: 1493-2501
- Prevalence of frailty in community-dwelling older persons: A systematic review.J Am Geriatr Soc. 2012; 60: 1487-1492
- Association of frailty with survival: A systematic literature review.Ageing Res Rev. 2013; 12: 719-736
- Sex differences in frailty: A systematic review and meta-analysis.Exp Gerontol. 2017; 89: 30-40
- Gender differences in the comparison of self-reported disability and performance measures.J Gerontol A Biol Sci Med Sci. 1997; 52: M19-M26
- Frailty, body mass index, and abdominal obesity in older people.J Gerontol A Biol Sci Med Sci. 2010; 65: 377-381
- Gender differences in inflammatory processes could explain poorer prognosis for males.J Clin Microbiol. 2011; 49: 478-479
- Inflammaging and skeletal muscle: Can protein intake make a difference?.J Nutr. 2016; 146: 1940-1952
- Nutrition and inflammation in older individuals: Focus on Vitamin D, n-3 polyunsaturated fatty acids and whey proteins.Nutrients. 2016; 8: 181
- Gender and health: An update on hypotheses and evidence.J Health Soc Behav. 1985; 26: 156-182
- Sex differences in morbidity and mortality.Demography. 2015; 42: 189-214
- Gender disparities in adult health: An examination of three measures of morbidity.J Health Soc Behav. 2006; 47: 95-110
- Why do women live longer than men?.Eur J Obstet Gynecol Reprod Biol. 2007; 133: 126-133
Article info
Publication history
Published online: November 10, 2017
Identification
Copyright
© 2017 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
ScienceDirect
Access this article on ScienceDirectLinked Article
- The Relationship Between the Dietary Inflammatory Index and Incident Frailty: A Longitudinal Cohort StudyJournal of the American Medical Directors AssociationVol. 19Issue 1
