In a recent issue of Journal of the American Medical Directors Association, Viscogliosi et al have achieved important results in testing safer and more effective
alternatives in the treatment of agitation in nursing home residents with Alzheimer
dementia (AD).
1
There is insufficient data on the comparison of citalopram with antipsychotics in
this regard, indicating that this study could make important contributions for beneficial
treatment options in agitation improvement in AD patients. Besides, the authors may
not have considered a few factors that could affect the results in the adjusted analysis.
The inclusion of factors such as delirium and the effect of different types of anti-dementia
drugs in the analysis are worth discussing.To read this article in full you will need to make a payment
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References
- Efficacy and safety of citalopram compared to atypical antipsychotics on agitation in nursing home residents with Alzheimer dementia.J Am Med Dir Assoc. 2017; 18: 799-802
- Subsyndromal delirium in older people: A systematic review of frequency, risk factors, course and outcomes.Int J Geriatr Psychiatry. 2013; 28: 771-880
- Preliminary derivation of a Nursing Home Confusion Assessment Method based on data from the Minimum Data Set.J Am Geriatr Soc. 2007; 55: 1099-1105
- Agitation in Patients With Dementia: A Practical Guide to Diagnosis and Management.American Psychiatric Publishing, Washington, DC2003
- Delirium in the nursing home.J Am Med Dir Assoc. 2013; 14: 632-634
- The effect of memantine on cognitive function and behavioral and psychological symptoms in mild-to-moderate Alzheimer's disease patients.Dement Geriatr Cogn Disord. 2015; 40: 85-93
- Differential effects of current specific treatments on behavioral and psychological symptoms in patients with Alzheimer's disease: A 12-month, randomized, open-label trial.J Alzheimers Dis. 2014; 39: 477-485
- Clinical efficacy and changes in the dosages of concomitantly used psychotropic drugs in memantine therapy in Alzheimer's disease with behavioral and psychological symptoms on dementia.Ther Adv Psychopharmacol. 2013; 3: 123-128
Article info
Publication history
Published online: November 15, 2017
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© 2017 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
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- Efficacy and Safety of Citalopram Compared With Atypical Antipsychotics on Agitation in Nursing Home Residents With Alzheimer DementiaJournal of the American Medical Directors AssociationVol. 19Issue 1
- PreviewWe are delighted to know that our article has captured the attention of readers. Regarding the findings of our previous study, Professor Naharci points out that unrecognized delirium could have had a relevant confounding effect and that the differential role of specific antidementia drugs should have been analyzed in detail. Delirium is a common geriatric syndrome with the highest incidence in acutely ill hospitalized older patients.1 Professor Naharci cited a retrospective study by Dosa et al2 reporting a very high occurrence of either full-spectrum or subsyndromal delirium among long-stay residents.
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