Abstract
Introduction
The effects of replacing sedentary time with light or moderate- to vigorous-intensity
physical activity on frailty are not well known.
Aim
To examine the mutually independent associations of sedentary time (ST), light-intensity
physical activity (LPA), and moderate- to vigorous-intensity physical activity (MVPA)
with frailty status in older adults.
Methods
A total of 628 people aged ≥65 years from the Toledo Study of Healthy Aging (TSHA)
participated in this cross-sectional study. Frailty was measured using the Frailty
Trait Scale. Hip-worn accelerometers were used to capture objective measurements of
ST, LPA, and MVPA. Linear regression and isotemporal substitution analyses were used
to examine associations of ST, LPA, and MVPA with frailty status. Analyses were also
stratified by comorbidity.
Results
In single and partition models, LPA and MVPA were negatively associated with frailty.
Time in sedentary behavior was not associated with frailty in these models. In the
isotemporal substitution models, replacing 30 minutes/d of ST with MVPA was associated
with a decrease in frailty [β −2.460; 95% confidence interval (CI): −3.782, −1.139].
In contrast, replacing ST with LPA was not associated with favorable effects on this
outcome. However, when the models were stratified by comorbidity, replacing ST with
MVPA had the greatest effect on frailty in both the comorbidity (β −2.556; 95% CI: −4.451, −0.661)
and the no comorbidity group (β −2.535; 95% CI: −4.343, −0.726). Moreover, the favorable
effects of LPA in people with comorbidities was found when replacing 30 minutes/d
of ST with LPA (β −0.568; 95% CI: −1.050, −0.086).
Conclusions
Substituting ST with MVPA is associated with theoretical positive effects on frailty.
People with comorbidity may also benefit from replacing ST with LPA, which may have
important clinical implications in order to decrease the levels of physical frailty.
Keywords
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Article info
Publication history
Published online: December 18, 2017
Footnotes
The authors declare no conflicts of interest.
This work was supported by the Biomedical Research Networking Center on Frailty and Healthy Aging (CIBERFES) and FEDER funds from the European Union (CB16/10/00477). It was further funded by grants from the Government of Castilla-La Mancha (PI2010/020; Institute of Health Sciences, Ministry of Health of Castilla-La Mancha, 03031-00), Spanish Government (Spanish Ministry of Economy, “Ministerio de Economía y Competitividad,” Instituto de Salud Carlos III, PI10/01532, PI031558, PI11/01068), and by European Grants (Seventh Framework Programme: FRAILOMIC). A.M. has received a PhD Grant from the Universidad de Castilla-La Mancha (2015/4062).
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© 2017 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
