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Update on Frailty Original Article| Volume 19, ISSUE 4, P315-322.e2, April 2018

Adherence to Mediterranean Diet and Frailty

Published:December 27, 2017DOI:https://doi.org/10.1016/j.jamda.2017.11.005

      Abstract

      Objective

      Το investigate associations between adherence to the Mediterranean diet and frailty in a Greek population of older adults.

      Design

      Cross-sectional study.

      Setting

      Data were drawn from the Hellenic longitudinal Investigation of Aging and Diet (HELIAD), a population-based, multidisciplinary study designed to estimate the prevalence and incidence of dementia in the Greek population.

      Participants

      Data from 1740 participants aged ≥65 years were included in the present analysis. Participants were selected through random sampling from the records of 2 Greek municipalities.

      Measurements

      Adherence to Mediterranean diet was evaluated through the MedDietScore, calculated from the information participants provided to a validated food frequency questionnaire. Frailty was assessed using 3 different definitions (the phenotypic approach proposed by Fried et al, the Frailty Index, and the Tilburg Frailty Indicator). Unadjusted and adjusted logistic and linear regression models were performed.

      Results

      Of our participants, 70 (4%), 325 (18.7%), and 442 (25.4%) were identified as frail according to the Fried et al definition, the Frailty Index, and the Tilburg Frailty Indicator, respectively. Adjusting for confounding factors, each additional unit in the MedDietScore was associated with a 5% (P = .09), 4% (P = .005), and 7% (P < .001) decrease in the odds for frailty according to the Fried definition, the Frailty Index, and the Tilburg Frailty Indicator, respectively.

      Conclusions

      According to study results, a higher adherence to the Mediterranean diet was associated with lower odds of frailty, irrespective of the definition used. This finding may be of relevance in the setting of population-based prevention efforts as well as in clinical practice.

      Keywords

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      References

        • Lunenfeld B.
        • Stratton P.
        The clinical consequences of an ageing world and preventive strategies.
        Best Pract Res Clin Obstet Gynaecol. 2013; 27: 643-659
        • Collard R.M.
        • Boter H.
        • Schoevers R.A.
        • Oude Voshaar R.C.
        Prevalence of frailty in community-dwelling older persons: A systematic review.
        J Am Geriatr Soc. 2012; 60: 1487-1492
        • Morley J.E.
        • Vellas B.
        • van Kan G.A.
        • et al.
        Frailty consensus: A call to action.
        J Am Med Dir Assoc. 2013; 14: 392-397
        • Yannakoulia M.
        • Ntanasi E.
        • Anastasiou C.A.
        • Scarmeas N.
        Frailty and nutrition: From epidemiological and clinical evidence to potential mechanisms.
        Metabolism. 2017; 68: 64-76
        • Beasley J.M.
        • LaCroix A.Z.
        • Neuhouser M.L.
        • et al.
        Protein intake and incident frailty in the Women's Health Initiative observational study.
        J Am Geriatr Soc. 2010; 58: 1063-1071
        • Bollwein J.
        • Diekmann R.
        • Kaiser M.J.
        • et al.
        Distribution but not amount of protein intake is associated with frailty: A cross-sectional investigation in the region of Nurnberg.
        Nutr J. 2013; 12: 109
        • Kobayashi S.
        • Asakura K.
        • Suga H.
        • Sasaki S.
        Three-generation Study of Women on Diets and Health Study Group. High protein intake is associated with low prevalence of frailty among old Japanese women: A multicenter cross-sectional study.
        Nutr J. 2013; 12: 164
        • Bartali B.
        • Frongillo E.A.
        • Bandinelli S.
        • et al.
        Low nutrient intake is an essential component of frailty in older persons.
        J Gerontol A Biol Sci Med Sci. 2006; 61: 589-593
        • Ensrud K.E.
        • Ewing S.K.
        • Fredman L.
        • et al.
        Circulating 25-hydroxyvitamin D levels and frailty status in older women.
        J Clin Endocrinol Metab. 2010; 95: 5266-5273
        • Shardell M.
        • D'Adamo C.
        • Alley D.E.
        • et al.
        Serum 25-hydroxyvitamin D, transitions between frailty states, and mortality in older adults: The Invecchiare in Chianti Study.
        J Am Geriatr Soc. 2012; 60: 256-264
        • Michelon E.
        • Blaum C.
        • Semba R.D.
        • et al.
        Vitamin and carotenoid status in older women: Associations with the frailty syndrome.
        J Gerontol A Biol Sci Med Sci. 2006; 61: 600-607
        • Wilhelm-Leen E.R.
        • Hall Y.N.
        • Deboer I.H.
        • Chertow G.M.
        Vitamin D deficiency and frailty in older Americans.
        J Intern Med. 2010; 268: 171-180
        • Shardell M.
        • Hicks G.E.
        • Miller R.R.
        • et al.
        Association of low vitamin D levels with the frailty syndrome in men and women.
        J Gerontol A Biol Sci Med Sci. 2009; 64: 69-75
        • Ble A.
        • Cherubini A.
        • Volpato S.
        • et al.
        Lower plasma vitamin E levels are associated with the frailty syndrome: The InCHIANTI study.
        J Gerontol A Biol Sci Med Sci. 2006; 61: 278-283
        • Robinson S.M.
        • Jameson K.A.
        • Batelaan S.F.
        • et al.
        Diet and its relationship with grip strength in community-dwelling older men and women: The Hertfordshire cohort study.
        J Am Geriatr Soc. 2008; 56: 84-90
        • Urpi-Sarda M.
        • Andres-Lacueva C.
        • Rabassa M.
        • et al.
        The relationship between urinary total polyphenols and the frailty phenotype in a community-dwelling older population: The InCHIANTI study.
        J Gerontol A Biol Sci Med Sci. 2015; 70: 1141-1147
        • Bollwein J.
        • Diekmann R.
        • Kaiser M.J.
        • et al.
        Dietary quality is related to frailty in community-dwelling older adults.
        J Gerontol A Biol Sci Med Sci. 2013; 68: 483-489
        • Talegawkar S.A.
        • Bandinelli S.
        • Bandeen-Roche K.
        • et al.
        A higher adherence to a Mediterranean-style diet is inversely associated with the development of frailty in community-dwelling elderly men and women.
        J Nutr. 2012; 142: 2161-2166
        • Chan R.
        • Leung J.
        • Woo J.
        Dietary patterns and risk of frailty in Chinese community-dwelling older people in Hong Kong: A prospective cohort study.
        Nutrients. 2015; 7: 7070-7084
        • Leon-Munoz L.M.
        • Guallar-Castillon P.
        • Lopez-Garcia E.
        • Rodriguez-Artalejo F.
        Mediterranean diet and risk of frailty in community-dwelling older adults.
        J Am Med Dir Assoc. 2014; 15: 899-903
        • Kafatos A.
        • Verhagen H.
        • Moschandreas J.
        • et al.
        Mediterranean diet of Crete: Foods and nutrient content.
        J Am Diet Assoc. 2000; 100: 1487-1493
        • Rahi B.
        • Ajana S.
        • Tabue-Teguo M.
        • et al.
        High adherence to a Mediterranean diet and lower risk of frailty among French older adults community-dwellers: Results from the Three-City-Bordeaux Study.
        Clin Nutr. 2017;
        • Fried L.P.
        • Tangen C.M.
        • Walston J.
        • et al.
        Frailty in older adults: Evidence for a phenotype.
        J Gerontol A Biol Sci Med Sci. 2001; 56: M146-M156
        • Dardiotis E.
        • Kosmidis M.H.
        • Yannakoulia M.
        • et al.
        The Hellenic Longitudinal Investigation of Aging and Diet (HELIAD): Rationale, study design, and cohort description.
        Neuroepidemiology. 2014; 43: 9-14
        • Folstein M.F.
        • Folstein S.E.
        • McHugh P.R.
        “Mini-mental state.” A practical method for grading the cognitive state of patients for the clinician.
        J Psychiatr Res. 1975; 12: 189-198
        • Lezak M.D.
        Neuropsychological Assessment.
        Oxford University Press, New York2004
        • Vlahou C.H.
        • Kosmidis M.H.
        • Dardagani A.
        • et al.
        Development of the Greek Verbal Learning Test: Reliability, construct validity, and normative standards.
        Arch Clin Neuropsychol. 2013; 28: 52-64
        • Kosmidis M.H.
        • Vlahou C.H.
        • Panagiotaki P.
        • Kiosseoglou G.
        The verbal fluency task in the Greek population: Normative data, and clustering and switching strategies.
        J Int Neuropsychol Soc. 2004; 10: 164-172
        • Tsapkini K.
        • Vlahou C.H.
        • Potagas C.
        Adaptation and validation of standardized aphasia tests in different languages: Lessons from the Boston Diagnostic Aphasia Examination - Short Form in Greek.
        Behav Neurol. 2010; 22: 111-119
        • Benton A.L.
        • Sivan A.B.
        • Hamsher K.D.
        • et al.
        Contributions to Neuropsychological Assessment: A Clinical Manual.
        2nd ed. Oxford University Press, New York1994
        • Kosmidis M.H.
        • Tsotsi S.
        • Karambela O.
        • et al.
        Cultural factors influencing performance on visuoperceptual neuropsychological tasks.
        Behav Neurol. 2010; 23: 245-247
        • Bozikas V.P.
        • Giazkoulidou A.
        • Hatzigeorgiadou M.
        • et al.
        Do age and education contribute to performance on the clock drawing test? Normative data for the Greek population.
        J Clin Exp Neuropsychol. 2008; 30: 199-203
        • Vlahou C.H.
        • Kosmidis M.H.
        The Greek Trail Making Test: Preliminary norms for clinical and research use.
        Psychology. 2002; 9: 336-352
        • Giaglis G.
        • Kyriazidou S.
        • Paraskevopoulou E.
        • et al.
        Evaluating premorbid level: Preliminary findings regarding the vulnerability of scores on cognitive measures in patients with MS [abstract].
        J Int Neuropsychol Soc. 2010; 15
        • Bountziouka V.
        • Bathrellou E.
        • Giotopoulou A.
        • et al.
        Development, repeatability and validity regarding energy and macronutrient intake of a semi-quantitative food frequency questionnaire: Methodological considerations.
        Nutr Metab Cardiovasc Dis. 2012; 22: 659-667
        • Anastasiou C.A.
        • Yannakoulia M.
        • Kosmidis M.H.
        • et al.
        Mediterranean diet and cognitive health: Initial results from the Hellenic Longitudinal Investigation of Ageing and Diet.
        PLoS One. 2017; 12: e0182048
        • Katsarou A.
        • Triposkiadis F.
        • Skoularigis J.
        • et al.
        Evaluating the role of perceived stress on the likelihood of having a non-fatal acute coronary syndrome: A case-control study.
        Open Cardiovasc Med J. 2014; 8: 68-75
        • Panagiotakos D.B.
        • Pitsavos C.
        • Stefanadis C.
        Dietary patterns: A Mediterranean diet score and its relation to clinical and biological markers of cardiovascular disease risk.
        Nutr Metab Cardiovasc Dis. 2006; 16: 559-568
        • Feart C.
        • Samieri C.
        • Alles B.
        • Barberger-Gateau P.
        Potential benefits of adherence to the Mediterranean diet on cognitive health.
        Proc Nutr Soc. 2013; 72: 140-152
        • Goldberg G.R.
        • Black A.E.
        • Jebb S.A.
        • et al.
        Critical evaluation of energy intake data using fundamental principles of energy physiology: 1. Derivation of cut-off limits to identify under-recording.
        Eur J Clin Nutr. 1991; 45: 569-581
        • Schofield W.N.
        Predicting basal metabolic rate, new standards and review of previous work.
        Hum Nutr Clin Nutr. 1985; 39: 5-41
        • Rockwood K.
        • Mitnitski A.
        Frailty in relation to the accumulation of deficits.
        J Gerontol A Biol Sci Med Sci. 2007; 62: 722-727
        • Gobbens R.J.
        • van Assen M.A.
        • Luijkx K.G.
        • et al.
        The Tilburg Frailty Indicator: Psychometric properties.
        J Am Med Dir Assoc. 2010; 11: 344-355
        • Yesavage J.A.
        Geriatric Depression Scale.
        Psychopharmacol Bull. 1988; 24: 709-711
        • Kavouras S.A.
        • Maraki M.
        • Kollia M.
        • et al.
        Development, reliability and validity of a physical activity questionnaire for estimating energy expenditure in Greek adults.
        Sci Sports. 2016; 31: e47-e53
        • Stenholm S.
        • Sallinen J.
        • Koster A.
        • et al.
        Association between obesity history and hand grip strength in older adults—exploring the roles of inflammation and insulin resistance as mediating factors.
        J Gerontol A Biol Sci Med Sci. 2011; 66: 341-348
        • Roubenoff R.
        Sarcopenic obesity: The confluence of two epidemics.
        Obes Res. 2004; 12: 887-888
        • Ortola R.
        • Garcia-Esquinas E.
        • Leon-Munoz L.M.
        • et al.
        Patterns of alcohol consumption and risk of frailty in community-dwelling older adults.
        J Gerontol A Biol Sci Med Sci. 2016; 71: 251-258
        • Smit E.
        • Winters-Stone K.M.
        • Loprinzi P.D.
        • et al.
        Lower nutritional status and higher food insufficiency in frail older US adults.
        Br J Nutr. 2013; 110: 172-178
        • Fountoulakis K.N.
        • Tsolaki M.
        • Iacovides A.
        • et al.
        The validation of the short form of the Geriatric Depression Scale (GDS) in Greece.
        Aging. 1999; 11: 367-372
        • Avila-Funes J.A.
        • Helmer C.
        • Amieva H.
        • et al.
        Frailty among community-dwelling elderly people in France: The three-city study.
        J Gerontol A Biol Sci Med Sci. 2008; 63: 1089-1096
        • Woods N.F.
        • LaCroix A.Z.
        • Gray S.L.
        • et al.
        Frailty: Emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study.
        J Am Geriatr Soc. 2005; 53: 1321-1330
        • Gobbens R.J.
        • van Assen M.A.
        • Luijkx K.G.
        • et al.
        Determinants of frailty.
        J Am Med Dir Assoc. 2010; 11: 356-364
        • Sternberg S.A.
        • Wershof Schwartz A.
        • Karunananthan S.
        • et al.
        The identification of frailty: A systematic literature review.
        J Am Geriatr Soc. 2011; 59: 2129-2138
        • Trichopoulou A.
        • Kouris-Blazos A.
        • Wahlqvist M.L.
        • et al.
        Diet and overall survival in elderly people.
        BMJ. 1995; 311: 1457-1460
        • Milaneschi Y.
        • Bandinelli S.
        • Corsi A.M.
        • et al.
        Mediterranean diet and mobility decline in older persons.
        Exp Gerontol. 2011; 46: 303-308
        • Shahar D.R.
        • Houston D.K.
        • Hue T.F.
        • et al.
        Adherence to mediterranean diet and decline in walking speed over 8 years in community-dwelling older adults.
        J Am Geriatr Soc. 2012; 60: 1881-1888
        • Naska A.
        • Trichopoulou A.
        Back to the future: The Mediterranean diet paradigm.
        Nutr Metab Cardiovasc Dis. 2014; 24: 216-219
        • Kregel K.C.
        • Zhang H.J.
        An integrated view of oxidative stress in aging: Basic mechanisms, functional effects, and pathological considerations.
        Am J Physiol Regul Integr Comp Physiol. 2007; 292: R18-R36
        • Mulero J.
        • Zafrilla P.
        • Martinez-Cacha A.
        Oxidative stress, frailty and cognitive decline.
        J Nutr Health Aging. 2011; 15: 756-760
        • Soysal P.
        • Stubbs B.
        • Lucato P.
        • et al.
        Inflammation and frailty in the elderly: A systematic review and meta-analysis.
        Ageing Res Rev. 2016; 31: 1-8
        • Esposito K.
        • Marfella R.
        • Ciotola M.
        • et al.
        Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: A randomized trial.
        JAMA. 2004; 292: 1440-1446
        • Chrysohoou C.
        • Panagiotakos D.B.
        • Pitsavos C.
        • et al.
        Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study.
        J Am Coll Cardiol. 2004; 44: 152-158
        • Yannakoulia M.
        • Tyrovolas S.
        • Pounis G.
        • et al.
        Correlates of low dietary energy reporting in free-living elderly: The MEDIS study.
        Maturitas. 2011; 69: 63-68
        • Scarmeas N.
        • Stern Y.
        • Mayeux R.
        • Luchsinger J.A.
        Mediterranean diet, Alzheimer disease, and vascular mediation.
        Arch Neurol. 2006; 63: 1709-1717
        • Scarmeas N.
        • Stern Y.
        • Tang M.X.
        • et al.
        Mediterranean diet and risk for Alzheimer's disease.
        Annals Neurol. 2006; 59: 912-921
        • Syddall H.
        • Roberts H.C.
        • Evandrou M.
        • et al.
        Prevalence and correlates of frailty among community-dwelling older men and women: Findings from the Hertfordshire Cohort Study.
        Age Ageing. 2010; 39: 197-203
        • Theou O.
        • Brothers T.D.
        • Mitnitski A.
        • Rockwood K.
        Operationalization of frailty using eight commonly used scales and comparison of their ability to predict all-cause mortality.
        J Am Geriatr Soc. 2013; 61: 1537-1551