In this issue appears a paper titled “Association of Polypharmacy With 1-Year Trajectories of Cognitive and Physical Function in Nursing Home Residents: Results From a Multicentre European Study.” The authors defined polypharmacy by medication count as either 5 to 9 drugs or ≥10 drugs, with 0 to 4 drugs as the reference. They found a relationship between polypharmacy and decline in cognitive function as measured by the Cognitive Performance Scale but not with functional status decline as measured by the Activities of Daily Living (ADL) Hierarchy scale. The choice to use the interRAI–Long Term Care Facilities (interRAI-LTCF) as opposed to the Minimum Data Set Version 3.0 (MDS 3.0) to derive their cognitive function measures limits the clinical application of the findings, as the MDS 3.0 has perhaps a more clinically interpretable cognitive function measure: the Brief Interview for Mental Status.
1Moreover, the measure of functional status used in this study (observed ADL) is not as sensitive to change as are performance measures such as the Short Physical Performance Battery.
- Saliba D.
- Buchanan J.
- Edelen M.O.
- et al.
MDS 3.0: Brief interview for mental status.
J Am Med Dir Assoc. 2012; 13: e611-e617
- Guralnik J.M.
- Simonsick E.M.
- Ferrucci L.
- et al.
A short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home.
J Gerontol. 1994; 49: M85-M94
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Journal of the American Medical Directors Association
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- MDS 3.0: Brief interview for mental status.J Am Med Dir Assoc. 2012; 13: e611-e617
- A short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home.J Gerontol. 1994; 49: M85-M94
- Polypharmacy, adverse drug reactions, and geriatric syndromes.Clin Geriatr Med. 2012; 28: 173-186
- Deprescribing: Achieving better health outcomes for older people through reducing medications.J Pharm Pract Res. 2003; 33: 323-328
- STOPPFrail (Screening Tool of Older Persons Prescriptions in Frail adults with limited life expectancy): Consensus validation.Age Aging. 2017; 46: 600-607
- Studies to reduce unnecessary medication use in frail older adults: A systematic review.Drugs Aging. 2013; 30: 285-307
- Medication withdrawal trials in people aged 65 years and older: A systematic review.Drugs Aging. 2008; 25: 1021-1031
- AGS updated Beers criteria for potentially inappropriate medication use in older adults.J Am Geriatr Soc. 2015; 63: 2227-2246
- STOPP/START criteria for potentially inappropriate prescribing in older people: Version 2.Age Ageing. 2015; 44: 213-218
- Alternative medications for 2015 National Committee for Quality Assurance’s Healthcare Effectiveness Data and Information Set criteria for high-risk medications and potentially harmful drug-disease interactions in the elderly.J Am Geriatr Soc. 2015; 63: e8-e18
- 2013. ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American College of Cardiology/American Heart Association task force on practice guidelines.J Am College Cardiol. 2014; 63: 2890-2932
- Deprescribing in older nursing home patients: Focus on innovative composite measures for dosage deintensification.Innov Aging. 2018; (online)
- International drug monitoring. The role of the hospital.World Health Organ Tech Rep Ser. 1969; 425: 5-24
- Meta-analysis of interventions to reduce adverse drug reactions in older adults.J Am Geriatr Soc. 2018; 66: 282-288
- Therapeutic failure-related hospitalizations in the frail elderly.Drugs Aging. 2006; 23: 579-586
- Prevalence of potentially preventable unplanned hospitalizations caused by therapeutic failures and adverse drug withdrawal events among older veterans.J Gerontol. 2012; 67: 867-874
Published online: May 31, 2018
The authors have no conflicts of interests to disclose.
© 2018 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
ScienceDirectAccess this article on ScienceDirect
- Association of Polypharmacy With 1-Year Trajectories of Cognitive and Physical Function in Nursing Home Residents: Results From a Multicenter European StudyJournal of the American Medical Directors AssociationVol. 19Issue 8