Abstract
Objectives
To assess the occurrence of 3 major adverse outcomes of sarcopenia (ie, physical disabilities,
institutionalizations and deaths) observed over a 3-year follow-up in older adults
and compare the risk of these outcomes using 5 definitions of sarcopenia.
Design
The study is a part of the ongoing SarcoPhAge (for Sarcopenia and Physical Impairment with advancing Age) longitudinal project.
Setting and Participants
The SarcoPhAge study follows 534 community-dwelling older adults.
Measures
Sarcopenia was defined as low muscle mass plus a decreased muscle function. Data on
adverse outcomes were collected yearly during the annual follow-up or with a phone
call. The association between baseline sarcopenia and the occurrence of undesirable
outcomes was tested using the Cox proportional hazards model or a logistic regression
model.
Results
A total of 534 subjects were recruited into this prospective cohort (73.5 ± 6.2 years,
60.5% female). After 3 years, 33 participants were lost to follow-up. If no association
between baseline sarcopenia and physical disabilities or institutionalizations was
highlighted, a higher number of deaths occurred in individuals diagnosed with sarcopenia
than in those who were not diagnosed (16.2% vs 4.6%, P value <.001). The probability of death within 3 years when presenting with sarcopenia
showed an approximately 3-fold increase compared to subjects without sarcopenia.
Conclusion
Over a 3-year period, sarcopenia at baseline was associated with an increased risk
of mortality. There were some variations in the ability of different definitions of
sarcopenia to predict outcomes.
Keywords
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Article Info
Publication History
Published online: July 19, 2018
Footnotes
The authors declare no conflicts of interest.
Identification
Copyright
© 2018 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
