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Review Article| Volume 19, ISSUE 12, P1069-1079, December 2018

Who Should Deliver Primary Care in Long-term Care Facilities to Optimize Resident Outcomes? A Systematic Review

Open AccessPublished:August 30, 2018DOI:https://doi.org/10.1016/j.jamda.2018.07.006

      Abstract

      Objective

      Across the world, health care for residents in long-term care facilities (LTCFs) is provided by a range of different professionals, and there is no consensus on which professional group(s) deliver the best outcomes for residents. The objective of this review is to investigate how the health outcomes of older adults in LTCFs vary according to which professional group(s) provides first-line medical care.

      Design

      A systematic review and narrative synthesis were performed. Medline, Embase, the Cochrane Central Register of Controlled Trials, and Scopus were searched for studies from high-income countries, of any design, published after 2000. Quality was assessed using the Cochrane Risk of Bias and ROBINS-I tools. The exposure of interest was the professional group(s) involved in the delivery of first-line primary care.

      Setting and participants

      Older adults living in LTCFs.

      Measures

      The principal outcomes were unplanned transfer to hospital, prescribing quality, and mortality.

      Results

      Searches identified 10,532 citations after removing duplicates. Twenty-six publications (across 24 studies) met the inclusion criteria. A narrative synthesis was conducted of the 20 experimental and 4 observational studies, involving approximately 98,000 residents. Seven studies were set in the USA, 6 in Australia, 3 in Canada, 2 in New Zealand, and 6 in European countries. Interventions were varied, complex and multi-faceted. Nineteen interventional studies, including 4 randomized trials, involved the addition of a specialist practitioner, either a doctor or nurse, to supplement usual primary care. The most commonly reported outcomes were unplanned hospital transfer and prescribing quality. Interventions based on specialist nurses were associated with reductions in unplanned hospital transfers in 10 out of 12 publications. There was no consistent evidence of a positive impact of specialist doctor interventions on unplanned hospital transfers. However, specialist doctors were associated with improvements in prescribing quality in all 7 relevant studies. There was a paucity of evidence on the impact of specialist nurse interventions on prescribing, and of specialist practitioners on mortality, and no improvements were reported.

      Conclusions

      Addition of specialist doctors or nurses to the first-line medical team has the potential to improve key health outcomes for residents in LTCFs.

      Keywords

      Health care in long-term care facilities (LTCFs) is a challenging area of clinical practice, where comorbidities, frailty, and polypharmacy are common.
      British Geriatrics Society
      Quest for quality: An inquiry into the quality of healthcare support for older people in care homes: A call for leadership, partnership and improvement; 2011.
      • Gordon A.
      What is the case for care home medicine? The geriatrician's perspective.
      Concerns have been voiced about the quality of acute and scheduled medical care for residents, and in particular, the high rates of in-hospital mortality,
      National Audit Office
      End of Life Care; 2008.
      inappropriate prescribing,
      • Shah S.M.
      • Carey I.M.
      • Harris T.
      • et al.
      Quality of prescribing in care homes and the community in England and Wales.
      and suboptimal chronic disease management.
      • Shah S.M.
      • Carey I.M.
      • Harris T.
      • et al.
      Quality of chronic disease care for older people in care homes and the community in a primary care pay for performance system: Retrospective study.
      In the search for ways to enhance health care in LTCFs, a key question is which professional group(s) achieves the best outcomes for residents when delivering first-line health care.
      The expertise of the medical professional involved in managing acute illness is thought to be one of the key influences on hospitalization of nursing home residents.
      • Ouslander J.G.
      • Lamb G.
      • Perloe M.
      • et al.
      Potentially avoidable hospitalizations of nursing home residents: Frequency, causes, and costs: [see editorial comments by Drs. Jean F. Wyman and William R. Hazzard, pp 760–761].
      Residents of LTCFs are frequent users of secondary care. They account for up to 2.4% of all emergency department (ED) presentations,
      • Arendts G.
      • Howard K.
      The interface between residential aged care and the emergency department: A systematic review.
      and are almost twice as likely to be hospitalized as their peers living in the community.
      • Ingarfield S.L.
      • Finn J.C.
      • Jacobs I.G.
      • et al.
      Use of emergency departments by older people from residential care: A population based study.
      Rates of avoidable hospitalization from nursing homes may be as high as 60%.
      • Spector W.D.
      • Limcangco R.
      • Williams C.
      • et al.
      Potentially avoidable hospitalizations for elderly long-stay residents in nursing homes.
      The estimated cost of potentially avoidable rehospitalization from US skilled nursing facilities alone is approximately $3.4 billion per annum.
      • Mor V.
      • Intrator O.
      • Feng Z.
      • Grabowski D.C.
      The revolving door of rehospitalization from skilled nursing facilities.
      A retrospective notes review of 235 ED attendances from residential facilities in Australia suggested that nearly one-third could have been avoided with improved primary care.
      • Codde J.
      • Frankel J.
      • Arendts G.
      • Babich P.
      Quantification of the proportion of transfers from residential aged care facilities to the emergency department that could be avoided through improved primary care services.
      Prescribing is influenced by training and disciplinary background, and can be associated with adverse outcomes for nursing home residents, including falls, hospital admission, and mortality.
      • Olazarán J.
      • Valle D.
      • Serra J.A.
      • et al.
      Psychotropic medications and falls in nursing homes: A cross-sectional study.
      • Lau D.T.
      • Kasper J.D.
      • Potter D.E.
      • et al.
      Hospitalization and death associated with potentially inappropriate medication prescriptions among elderly nursing home residents.
      Primary care generalists, such as family physicians and general practitioners, are commonly responsible for the delivery of first-line health care to LTCF residents. Primary care generalists provide first-line care without prior vetting for a variety of conditions across the whole age range.
      • Howe A.
      Medical Generalism: Why expertise in whole person medicine matters; 2012.
      In some countries, geriatricians (specialist doctors who adopt a generalist approach for older adults
      • Howe A.
      Medical Generalism: Why expertise in whole person medicine matters; 2012.
      ) look after residents of LTCFs, but the Netherlands is the only country in the world where “elderly care physicians” in nursing homes have a stand-alone 3-year training program.
      • Koopmans R.T.C.M.
      • Pellegrom M.
      • van der Geer E.R.
      The Dutch move beyond the concept of nursing home physician specialists.
      • Conroy S.
      • Van Der Cammen T.
      • Schols J.
      • et al.
      Medical services for older people in nursing homes—comparing services in England and the Netherlands.
      Specialist nurses or nurse practitioners may also deliver first-line primary care, often with delegated clinical responsibility. The level of involvement of nurse practitioners varies widely from country to country. Nurse practitioners have worked in US long-term care homes for approximately 30 years,
      • McAiney C.A.
      • Haughton D.
      • Jennings J.
      • et al.
      A unique practice model for nurse practitioners in long-term care homes.
      where they have performed diverse roles including first-line clinical assessments of residents (acting as the clinician), care manager, coach, and educator for nursing staff.
      • Abdallah L.M.
      EverCare nurse practitioner practice activities: Similarities and differences across five sites.
      There is no international consensus on which professional group should provide care for residents in LTCFs. Specialist practitioners with enhanced training and experience in the medical needs of residents in LTCFs may be better placed to manage the medical complexity of residents.
      • Katz P.R.
      • Karuza J.
      • Intrator O.
      • Mor V.
      Nursing home physician specialists: A response to the workforce crisis in long-term care.
      In the United Kingdom, greater involvement of geriatricians is suggested as a means to improve the quality of medical care for residents in LTCFs,
      • Gordon A.
      What is the case for care home medicine? The geriatrician's perspective.
      and there have been calls to adopt a geriatrician-led model in US LTCFs.
      • Katz P.R.
      • Karuza J.
      • Intrator O.
      • Mor V.
      Nursing home physician specialists: A response to the workforce crisis in long-term care.
      Multidisciplinary teams (MDTs) and the involvement of specialist practitioners have also been suggested as a means to improve prescribing outcomes.
      • Burns E.
      • Nair S.
      New horizons in care home medicine.
      It is plausible that specialist doctors or nurses may recognize acute illness and intervene promptly.
      • Szczepura A.
      • Nelson S.
      • Wild D.
      In-reach specialist nursing teams for residential care homes: Uptake of services, impact on care provision and cost-effectiveness.
      Practitioners with a specific remit for nursing home residents may be able to prioritize advanced care planning and develop expertise in complex prescribing to enhance chronic disease management.
      • Katz P.R.
      • Karuza J.
      • Intrator O.
      • Mor V.
      Nursing home physician specialists: A response to the workforce crisis in long-term care.
      The American Geriatrics Society
      Geriatric Medicine: A clinical imperative for an ageing population, part 1A policy statement from the American Geriatrics Society.
      • D'Arcy L.P.
      • Stearns S.C.
      • Domino M.E.
      • et al.
      Is geriatric care associated with less emergency department use?.
      It is an international priority to improve health care for residents in LTCFs and find the most effective way of delivering primary medical care. The aim of this review is to systematically identify and synthesize evidence on which professional group should provide first-line medical care (routine and/or unscheduled) for residents in LTCFs to enhance health outcomes. In doing so we will address the question of how the health outcomes of residents vary according to which professional group (primary care generalist, generalist specialist, nurse practitioner, and specialist multidisciplinary team) provides first-line medical care. We will also ask how health outcomes for residents who receive first-line primary care from primary care generalists differ from those who receive care from specialist practitioners. The hypothesis is that improved health outcomes will be observed when practitioners, with enhanced expertise and experience relevant to this patient population, are involved in the delivery of first-line primary care.

      Methods

      Search Strategy

      We searched for empirical research involving adults aged 65 years or older and living in LTCFs that compared health outcomes for different practitioners involved in the delivery of first-line primary care. The following bibliographic database searches were initially conducted in October 2016: Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Scopus. An individual search strategy was used for each database. The keywords used were common for Medline, Embase, and CENTRAL but the MeSH headings were individually tailored to the different databases. The searches were updated in October 2017 to identify any further studies published in the period of undertaking the review. Bibliography searches and citation searches were performed for publications included in the final synthesis. A gray literature search was conducted for articles published by key organizations: the British Geriatrics Society, King's Fund and Nuffield Trust. The review protocol was registered on PROSPERO (CRD42016049019).

      Eligibility Criteria

      Studies of any design conducted in high-income countries, published after 2000 in any language, were included if they focused on older adults in LTCFs (including institutions with and without on-site nursing input) and represented quantitative data. The exposure or intervention of interest is the professional group(s) involved in the delivery of first-line primary care. Studies without a defined comparator group were excluded as they do not allow comparison between different professional groups. To be included, the practitioner had to have the expertise to respond to, and manage, primary care problems, that is, to act as the main first-line primary care figure, either with autonomous or delegated clinical responsibility.
      • Martínez-González N.A.
      • Djalali S.
      • Tandjung R.
      • et al.
      Substitution of physicians by nurses in primary care: A systematic review and meta-analysis.
      This includes specialist doctors such as care home physicians and geriatricians, primary care generalists including general practitioners and family physicians, and specialist multidisciplinary teams. Nurse practitioners and physician assistants, who may receive support in decision making from a doctor, are also eligible for inclusion. Exposures or interventions based solely on medication review by a clinical pharmacist, who then makes a prescribing recommendation to the responsible clinician, were excluded.
      The health outcomes of interest were quantitative and those expected to be influenced by first-line medical care providers. The principal outcomes were unplanned transfer to hospital (such as ED visits or unplanned hospitalization), prescribing quality outcomes (including appropriateness of prescribing and number of medications prescribed), chronic disease management indicators, and mortality. Other important quality indicators (eg, fall frequency and restraint use) that are dependent on other factors such as the quality of nursing care were only included if reported in conjunction with one of the principal outcomes described above. Inclusion criteria were tested independently by 2 researchers on 10% of the records and minor revisions made before proceeding with study selection.

      Study Screening and Data Extraction

      At the title and abstract screening phase, all citations were screened by a single author, and one-third of citations were double-screened. Screening discrepancies (less than 5%) were discussed individually. If a consensus was not achieved, the citation was put forward for full text review. Full texts were then read and assessed for inclusion in the review by 2 authors independently. Study details and data were extracted into an Excel spreadsheet for the included studies. Data extraction was performed by one researcher and independently checked for accuracy by a second researcher.

      Methodologic Quality

      Quality assessment was performed independently by 2 members of the research team. The Cochrane Risk of Bias tool was chosen for the 5 randomized studies. For the nonrandomized studies, the Cochrane ROBINS-I (Risk Of Bias In Non-randomized Studies of Interventions) tool was employed.

      Data Synthesis

      The possibility of pooling data for a meta-analysis was explored but this was not possible because of the high degree of heterogeneity in study setting, exposures/interventions, and the outcomes reported. Therefore, only a narrative synthesis was performed.

      Results

      After the removal of duplicates, the searches produced 10,532 citations. Following title and abstract screening, 125 full-text articles were assessed for eligibility. Twenty-six publications
      • D'Arcy L.P.
      • Stearns S.C.
      • Domino M.E.
      • et al.
      Is geriatric care associated with less emergency department use?.
      • Bandurchin A.
      • McNally M.J.
      • Ferguson-Pare M.
      Bringing back the house call: How an emergency mobile nursing service is reducing avoidable emergency department visits for residents in long-term care homes.
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      • Boyd M.
      • Armstrong D.
      • Parker J.
      • et al.
      Do gerontology nurse specialists make a difference in hospitalization of long-term care residents? Results of a randomized comparison trial.
      • Codde J.
      • Arendts G.
      • Frankel J.
      • et al.
      Transfers from residential aged care facilities to the emergency department are reduced through improved primary care services: An intervention study.
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      • Connolly M.J.
      • Broad J.B.
      • Boyd M.
      • et al.
      The “Big Five.” Hypothesis generation: A multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: A post hoc analysis of the ARCHUS cluster-randomised controlled trial.
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      • Díaz-Gegúndez M.
      • Paluzie G.
      • Sanz-Ballester C.
      • et al.
      Evaluación de un programa de intervención en residencias geriátricas para reducir la frecuentación hospitalaria.
      • El-Masri M.M.
      • Omar A.
      • Groh E.M.
      Evaluating the effectiveness of a nurse practitioner-led outreach program for long-term-care homes.
      • Fan L.
      • Hou X.-Y.
      • Zhao J.
      • et al.
      Hospital in the Nursing Home program reduces emergency department presentations and hospital admissions from residential aged care facilities in Queensland, Australia: A quasi-experimental study.
      • Gloth 3rd, F.M.
      • Gloth M.J.
      A comparative effectiveness trial between a post-acute care hospitalist model and a community-based physician model of nursing home care.
      • Hutchinson A.F.
      • Parikh S.
      • Tacey M.
      • et al.
      A longitudinal cohort study evaluating the impact of a geriatrician-led residential care outreach service on acute healthcare utilisation.
      • Kane R.L.
      • Flood S.
      • Bershadsky B.
      • Keckhafer G.
      Effect of an innovative medicare managed care program on the quality of care for nursing home residents.
      • Kane R.L.
      • Keckhafer G.
      • Flood S.
      • et al.
      The effect of EverCare on hospital use.
      • King M.A.
      • Roberts M.S.
      Multidisciplinary case conference reviews: Improving outcomes for nursing home residents, carers and health professionals.
      • Klaasen K.
      • Lamont L.
      • Krishnan P.
      Setting a new standard of care in nursing homes.
      • Lisk R.
      • Yeong K.
      • Nasim A.
      • et al.
      Geriatrician input into nursing homes reduces emergency hospital admissions.
      • McKee H.
      • Miller R.
      • Cuthbertson J.
      • et al.
      Nursing Home Outreach Clinics show an improvement in patient safety and reduction in hospital admissions in residents with chronic conditions.
      • Rantz M.J.
      • Popejoy L.
      • Vogelsmeier A.
      • et al.
      Successfully reducing hospitalizations of nursing home residents: Results of the Missouri Quality Initiative.
      • Schippinger W.
      • Hartinger G.
      • Hierzer A.
      • et al.
      Mobile geriatric consultant services for rest homes. Study of the effects of consultations by internal medicine specialists in the medical care of rest home residents.
      • Street M.
      • Considine J.
      • Livingston P.
      • et al.
      In-reach nursing services improve older patient outcomes and access to emergency care.
      • Tamura B.K.
      • Bell C.L.
      • Lubimir K.
      • et al.
      Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes project.
      • Aigner M.J.
      • Drew S.
      • Phipps J.
      A comparative study of nursing home resident outcomes between care provided by nurse practitioners/physicians versus physicians only.
      • Monroe T.
      • Carter M.
      • Parish A.
      A case study using the Beers List criteria to compare prescribing by family practitioners and geriatric specialists in a rural nursing home.
      • Pittrow D.
      • Krappweis J.
      • Rentsch A.
      • et al.
      Pattern of prescriptions issued by nursing home-based physicians versus office-based physicians for frail elderly patients in German nursing homes.
      from 24 different studies were included in the synthesis. The study selection process is shown in Figure 1.
      Figure thumbnail gr1
      Fig. 1PRISMA diagram showing study selection.

      Descriptive Synthesis

      There were 22 experimental
      • Bandurchin A.
      • McNally M.J.
      • Ferguson-Pare M.
      Bringing back the house call: How an emergency mobile nursing service is reducing avoidable emergency department visits for residents in long-term care homes.
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      • Boyd M.
      • Armstrong D.
      • Parker J.
      • et al.
      Do gerontology nurse specialists make a difference in hospitalization of long-term care residents? Results of a randomized comparison trial.
      • Codde J.
      • Arendts G.
      • Frankel J.
      • et al.
      Transfers from residential aged care facilities to the emergency department are reduced through improved primary care services: An intervention study.
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      • Connolly M.J.
      • Broad J.B.
      • Boyd M.
      • et al.
      The “Big Five.” Hypothesis generation: A multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: A post hoc analysis of the ARCHUS cluster-randomised controlled trial.
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      • Díaz-Gegúndez M.
      • Paluzie G.
      • Sanz-Ballester C.
      • et al.
      Evaluación de un programa de intervención en residencias geriátricas para reducir la frecuentación hospitalaria.
      • El-Masri M.M.
      • Omar A.
      • Groh E.M.
      Evaluating the effectiveness of a nurse practitioner-led outreach program for long-term-care homes.
      • Fan L.
      • Hou X.-Y.
      • Zhao J.
      • et al.
      Hospital in the Nursing Home program reduces emergency department presentations and hospital admissions from residential aged care facilities in Queensland, Australia: A quasi-experimental study.
      • Gloth 3rd, F.M.
      • Gloth M.J.
      A comparative effectiveness trial between a post-acute care hospitalist model and a community-based physician model of nursing home care.
      • Hutchinson A.F.
      • Parikh S.
      • Tacey M.
      • et al.
      A longitudinal cohort study evaluating the impact of a geriatrician-led residential care outreach service on acute healthcare utilisation.
      • Kane R.L.
      • Flood S.
      • Bershadsky B.
      • Keckhafer G.
      Effect of an innovative medicare managed care program on the quality of care for nursing home residents.
      • Kane R.L.
      • Keckhafer G.
      • Flood S.
      • et al.
      The effect of EverCare on hospital use.
      • King M.A.
      • Roberts M.S.
      Multidisciplinary case conference reviews: Improving outcomes for nursing home residents, carers and health professionals.
      • Klaasen K.
      • Lamont L.
      • Krishnan P.
      Setting a new standard of care in nursing homes.
      • Lisk R.
      • Yeong K.
      • Nasim A.
      • et al.
      Geriatrician input into nursing homes reduces emergency hospital admissions.
      • McKee H.
      • Miller R.
      • Cuthbertson J.
      • et al.
      Nursing Home Outreach Clinics show an improvement in patient safety and reduction in hospital admissions in residents with chronic conditions.
      • Rantz M.J.
      • Popejoy L.
      • Vogelsmeier A.
      • et al.
      Successfully reducing hospitalizations of nursing home residents: Results of the Missouri Quality Initiative.
      • Schippinger W.
      • Hartinger G.
      • Hierzer A.
      • et al.
      Mobile geriatric consultant services for rest homes. Study of the effects of consultations by internal medicine specialists in the medical care of rest home residents.
      • Street M.
      • Considine J.
      • Livingston P.
      • et al.
      In-reach nursing services improve older patient outcomes and access to emergency care.
      • Tamura B.K.
      • Bell C.L.
      • Lubimir K.
      • et al.
      Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes project.
      and 4 observational
      • D'Arcy L.P.
      • Stearns S.C.
      • Domino M.E.
      • et al.
      Is geriatric care associated with less emergency department use?.
      • Aigner M.J.
      • Drew S.
      • Phipps J.
      A comparative study of nursing home resident outcomes between care provided by nurse practitioners/physicians versus physicians only.
      • Monroe T.
      • Carter M.
      • Parish A.
      A case study using the Beers List criteria to compare prescribing by family practitioners and geriatric specialists in a rural nursing home.
      • Pittrow D.
      • Krappweis J.
      • Rentsch A.
      • et al.
      Pattern of prescriptions issued by nursing home-based physicians versus office-based physicians for frail elderly patients in German nursing homes.
      publications (across 24 studies), involving approximately 98,000 residents in 9 different countries. Eight publications (7 studies) were set in the United States,
      • D'Arcy L.P.
      • Stearns S.C.
      • Domino M.E.
      • et al.
      Is geriatric care associated with less emergency department use?.
      • Gloth 3rd, F.M.
      • Gloth M.J.
      A comparative effectiveness trial between a post-acute care hospitalist model and a community-based physician model of nursing home care.
      • Kane R.L.
      • Flood S.
      • Bershadsky B.
      • Keckhafer G.
      Effect of an innovative medicare managed care program on the quality of care for nursing home residents.
      • Kane R.L.
      • Keckhafer G.
      • Flood S.
      • et al.
      The effect of EverCare on hospital use.
      • Rantz M.J.
      • Popejoy L.
      • Vogelsmeier A.
      • et al.
      Successfully reducing hospitalizations of nursing home residents: Results of the Missouri Quality Initiative.
      • Tamura B.K.
      • Bell C.L.
      • Lubimir K.
      • et al.
      Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes project.
      • Aigner M.J.
      • Drew S.
      • Phipps J.
      A comparative study of nursing home resident outcomes between care provided by nurse practitioners/physicians versus physicians only.
      • Monroe T.
      • Carter M.
      • Parish A.
      A case study using the Beers List criteria to compare prescribing by family practitioners and geriatric specialists in a rural nursing home.
      3 in Canada,
      • Bandurchin A.
      • McNally M.J.
      • Ferguson-Pare M.
      Bringing back the house call: How an emergency mobile nursing service is reducing avoidable emergency department visits for residents in long-term care homes.
      • El-Masri M.M.
      • Omar A.
      • Groh E.M.
      Evaluating the effectiveness of a nurse practitioner-led outreach program for long-term-care homes.
      • Klaasen K.
      • Lamont L.
      • Krishnan P.
      Setting a new standard of care in nursing homes.
      6 in Australia,
      • Codde J.
      • Frankel J.
      • Arendts G.
      • Babich P.
      Quantification of the proportion of transfers from residential aged care facilities to the emergency department that could be avoided through improved primary care services.
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      • Fan L.
      • Hou X.-Y.
      • Zhao J.
      • et al.
      Hospital in the Nursing Home program reduces emergency department presentations and hospital admissions from residential aged care facilities in Queensland, Australia: A quasi-experimental study.
      • Hutchinson A.F.
      • Parikh S.
      • Tacey M.
      • et al.
      A longitudinal cohort study evaluating the impact of a geriatrician-led residential care outreach service on acute healthcare utilisation.
      • King M.A.
      • Roberts M.S.
      Multidisciplinary case conference reviews: Improving outcomes for nursing home residents, carers and health professionals.
      • Street M.
      • Considine J.
      • Livingston P.
      • et al.
      In-reach nursing services improve older patient outcomes and access to emergency care.
      3 (2 studies) in New Zealand,
      • Boyd M.
      • Armstrong D.
      • Parker J.
      • et al.
      Do gerontology nurse specialists make a difference in hospitalization of long-term care residents? Results of a randomized comparison trial.
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      • Connolly M.J.
      • Broad J.B.
      • Boyd M.
      • et al.
      The “Big Five.” Hypothesis generation: A multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: A post hoc analysis of the ARCHUS cluster-randomised controlled trial.
      and 6 in European countries (United Kingdom,
      • Lisk R.
      • Yeong K.
      • Nasim A.
      • et al.
      Geriatrician input into nursing homes reduces emergency hospital admissions.
      • McKee H.
      • Miller R.
      • Cuthbertson J.
      • et al.
      Nursing Home Outreach Clinics show an improvement in patient safety and reduction in hospital admissions in residents with chronic conditions.
      Germany,
      • Pittrow D.
      • Krappweis J.
      • Rentsch A.
      • et al.
      Pattern of prescriptions issued by nursing home-based physicians versus office-based physicians for frail elderly patients in German nursing homes.
      Spain,
      • Díaz-Gegúndez M.
      • Paluzie G.
      • Sanz-Ballester C.
      • et al.
      Evaluación de un programa de intervención en residencias geriátricas para reducir la frecuentación hospitalaria.
      Austria,
      • Schippinger W.
      • Hartinger G.
      • Hierzer A.
      • et al.
      Mobile geriatric consultant services for rest homes. Study of the effects of consultations by internal medicine specialists in the medical care of rest home residents.
      and the Netherlands
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      ). Two studies were non-English publications.
      • Díaz-Gegúndez M.
      • Paluzie G.
      • Sanz-Ballester C.
      • et al.
      Evaluación de un programa de intervención en residencias geriátricas para reducir la frecuentación hospitalaria.
      • Schippinger W.
      • Hartinger G.
      • Hierzer A.
      • et al.
      Mobile geriatric consultant services for rest homes. Study of the effects of consultations by internal medicine specialists in the medical care of rest home residents.
      Among the 22 experimental publications, there were 5 randomized controlled trials (RCTs)
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      • Boyd M.
      • Armstrong D.
      • Parker J.
      • et al.
      Do gerontology nurse specialists make a difference in hospitalization of long-term care residents? Results of a randomized comparison trial.
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      • Connolly M.J.
      • Broad J.B.
      • Boyd M.
      • et al.
      The “Big Five.” Hypothesis generation: A multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: A post hoc analysis of the ARCHUS cluster-randomised controlled trial.
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      and 17 nonrandomized experimental studies.
      • Bandurchin A.
      • McNally M.J.
      • Ferguson-Pare M.
      Bringing back the house call: How an emergency mobile nursing service is reducing avoidable emergency department visits for residents in long-term care homes.
      • Codde J.
      • Arendts G.
      • Frankel J.
      • et al.
      Transfers from residential aged care facilities to the emergency department are reduced through improved primary care services: An intervention study.
      • Díaz-Gegúndez M.
      • Paluzie G.
      • Sanz-Ballester C.
      • et al.
      Evaluación de un programa de intervención en residencias geriátricas para reducir la frecuentación hospitalaria.
      • El-Masri M.M.
      • Omar A.
      • Groh E.M.
      Evaluating the effectiveness of a nurse practitioner-led outreach program for long-term-care homes.
      • Fan L.
      • Hou X.-Y.
      • Zhao J.
      • et al.
      Hospital in the Nursing Home program reduces emergency department presentations and hospital admissions from residential aged care facilities in Queensland, Australia: A quasi-experimental study.
      • Gloth 3rd, F.M.
      • Gloth M.J.
      A comparative effectiveness trial between a post-acute care hospitalist model and a community-based physician model of nursing home care.
      • Hutchinson A.F.
      • Parikh S.
      • Tacey M.
      • et al.
      A longitudinal cohort study evaluating the impact of a geriatrician-led residential care outreach service on acute healthcare utilisation.
      • Kane R.L.
      • Flood S.
      • Bershadsky B.
      • Keckhafer G.
      Effect of an innovative medicare managed care program on the quality of care for nursing home residents.
      • Kane R.L.
      • Keckhafer G.
      • Flood S.
      • et al.
      The effect of EverCare on hospital use.
      • King M.A.
      • Roberts M.S.
      Multidisciplinary case conference reviews: Improving outcomes for nursing home residents, carers and health professionals.
      • Klaasen K.
      • Lamont L.
      • Krishnan P.
      Setting a new standard of care in nursing homes.
      • Lisk R.
      • Yeong K.
      • Nasim A.
      • et al.
      Geriatrician input into nursing homes reduces emergency hospital admissions.
      • McKee H.
      • Miller R.
      • Cuthbertson J.
      • et al.
      Nursing Home Outreach Clinics show an improvement in patient safety and reduction in hospital admissions in residents with chronic conditions.
      • Rantz M.J.
      • Popejoy L.
      • Vogelsmeier A.
      • et al.
      Successfully reducing hospitalizations of nursing home residents: Results of the Missouri Quality Initiative.
      • Schippinger W.
      • Hartinger G.
      • Hierzer A.
      • et al.
      Mobile geriatric consultant services for rest homes. Study of the effects of consultations by internal medicine specialists in the medical care of rest home residents.
      • Street M.
      • Considine J.
      • Livingston P.
      • et al.
      In-reach nursing services improve older patient outcomes and access to emergency care.
      • Tamura B.K.
      • Bell C.L.
      • Lubimir K.
      • et al.
      Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes project.
      All studies were conducted in LTCFs caring for older adults, although the age is not reported in 5 instances.
      • Bandurchin A.
      • McNally M.J.
      • Ferguson-Pare M.
      Bringing back the house call: How an emergency mobile nursing service is reducing avoidable emergency department visits for residents in long-term care homes.
      • Codde J.
      • Arendts G.
      • Frankel J.
      • et al.
      Transfers from residential aged care facilities to the emergency department are reduced through improved primary care services: An intervention study.
      • Díaz-Gegúndez M.
      • Paluzie G.
      • Sanz-Ballester C.
      • et al.
      Evaluación de un programa de intervención en residencias geriátricas para reducir la frecuentación hospitalaria.
      • Kane R.L.
      • Flood S.
      • Bershadsky B.
      • Keckhafer G.
      Effect of an innovative medicare managed care program on the quality of care for nursing home residents.
      • Lisk R.
      • Yeong K.
      • Nasim A.
      • et al.
      Geriatrician input into nursing homes reduces emergency hospital admissions.
      A wide range of terms were used to describe the facilities, as shown in Table 1. Sixteen publications used the term nursing home,
      • D'Arcy L.P.
      • Stearns S.C.
      • Domino M.E.
      • et al.
      Is geriatric care associated with less emergency department use?.
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      • Díaz-Gegúndez M.
      • Paluzie G.
      • Sanz-Ballester C.
      • et al.
      Evaluación de un programa de intervención en residencias geriátricas para reducir la frecuentación hospitalaria.
      • Gloth 3rd, F.M.
      • Gloth M.J.
      A comparative effectiveness trial between a post-acute care hospitalist model and a community-based physician model of nursing home care.
      • Kane R.L.
      • Flood S.
      • Bershadsky B.
      • Keckhafer G.
      Effect of an innovative medicare managed care program on the quality of care for nursing home residents.
      • Kane R.L.
      • Keckhafer G.
      • Flood S.
      • et al.
      The effect of EverCare on hospital use.
      • King M.A.
      • Roberts M.S.
      Multidisciplinary case conference reviews: Improving outcomes for nursing home residents, carers and health professionals.
      • Klaasen K.
      • Lamont L.
      • Krishnan P.
      Setting a new standard of care in nursing homes.
      • Lisk R.
      • Yeong K.
      • Nasim A.
      • et al.
      Geriatrician input into nursing homes reduces emergency hospital admissions.
      • McKee H.
      • Miller R.
      • Cuthbertson J.
      • et al.
      Nursing Home Outreach Clinics show an improvement in patient safety and reduction in hospital admissions in residents with chronic conditions.
      • Rantz M.J.
      • Popejoy L.
      • Vogelsmeier A.
      • et al.
      Successfully reducing hospitalizations of nursing home residents: Results of the Missouri Quality Initiative.
      • Schippinger W.
      • Hartinger G.
      • Hierzer A.
      • et al.
      Mobile geriatric consultant services for rest homes. Study of the effects of consultations by internal medicine specialists in the medical care of rest home residents.
      • Tamura B.K.
      • Bell C.L.
      • Lubimir K.
      • et al.
      Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes project.
      • Aigner M.J.
      • Drew S.
      • Phipps J.
      A comparative study of nursing home resident outcomes between care provided by nurse practitioners/physicians versus physicians only.
      • Monroe T.
      • Carter M.
      • Parish A.
      A case study using the Beers List criteria to compare prescribing by family practitioners and geriatric specialists in a rural nursing home.
      • Pittrow D.
      • Krappweis J.
      • Rentsch A.
      • et al.
      Pattern of prescriptions issued by nursing home-based physicians versus office-based physicians for frail elderly patients in German nursing homes.
      6 contained residential facility within the description of the facility,
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      • Boyd M.
      • Armstrong D.
      • Parker J.
      • et al.
      Do gerontology nurse specialists make a difference in hospitalization of long-term care residents? Results of a randomized comparison trial.
      • Codde J.
      • Arendts G.
      • Frankel J.
      • et al.
      Transfers from residential aged care facilities to the emergency department are reduced through improved primary care services: An intervention study.
      • Fan L.
      • Hou X.-Y.
      • Zhao J.
      • et al.
      Hospital in the Nursing Home program reduces emergency department presentations and hospital admissions from residential aged care facilities in Queensland, Australia: A quasi-experimental study.
      • Hutchinson A.F.
      • Parikh S.
      • Tacey M.
      • et al.
      A longitudinal cohort study evaluating the impact of a geriatrician-led residential care outreach service on acute healthcare utilisation.
      • Street M.
      • Considine J.
      • Livingston P.
      • et al.
      In-reach nursing services improve older patient outcomes and access to emergency care.
      and 4 publications employed the term long-term care home
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      • Connolly M.J.
      • Broad J.B.
      • Boyd M.
      • et al.
      The “Big Five.” Hypothesis generation: A multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: A post hoc analysis of the ARCHUS cluster-randomised controlled trial.
      or long-term care facility.
      • Bandurchin A.
      • McNally M.J.
      • Ferguson-Pare M.
      Bringing back the house call: How an emergency mobile nursing service is reducing avoidable emergency department visits for residents in long-term care homes.
      • El-Masri M.M.
      • Omar A.
      • Groh E.M.
      Evaluating the effectiveness of a nurse practitioner-led outreach program for long-term-care homes.
      Table 1Summary of Included Studies
      Author (year)Study Design CategoryStudy Design as Described (as Interpreted if Not Stated)Description of Long-term Care FacilityCountryNumber of ParticipantsResident AgeQuality Assessment (Domains of Serious Risk for ROBINS-I Tool)
      Specialist doctor interventions
       Boorsma
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      (2011)
      Randomized trialCluster RCTResidential care facilitiesThe NetherlandsIntervention: 291

      Control: 171
      Mean (SD):

      Intervention: 85.8 (6.2)

      Control: 85.8 (8.0)
      See Figure 2
       Connolly
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      (2015)
      Also forms part of the specialist nurse category.
      Randomized trialCluster RCTLong-term care facilities (rest home, rest home and hospital combined)New ZealandIntervention: 1123

      Controls 875
      More than 95% of participants, >65 ySee Figure 2
       Connolly
      • Connolly M.J.
      • Broad J.B.
      • Boyd M.
      • et al.
      The “Big Five.” Hypothesis generation: A multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: A post hoc analysis of the ARCHUS cluster-randomised controlled trial.
      (2016)
      Also forms part of the specialist nurse category.
      Randomized trialPost hoc analysis of cluster RCTLong-term care facilities (rest home, rest home and hospital combined)New ZealandIntervention: 1123

      Controls 875
      Mean:

      82.9 y
      See Figure 2
       Crotty
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      (2004)
      Randomized trialCluster RCTNursing homeAustraliaIntervention: 50

      Control–in: 50

      Control–out: 54
      Mean (95% CI):

      Control: 83.8 (81.3-85.9)

      Within-facility controls: 84.6 (83.2-86)

      Intervention: 85.3 (84-86.6)
      See Figure 2
       D'Arcy
      • D'Arcy L.P.
      • Stearns S.C.
      • Domino M.E.
      • et al.
      Is geriatric care associated with less emergency department use?.
      (2013)
      ObservationalRetrospective cohortNursing homeUS66,551 residents (with a history of cardiovascular disease and a common geriatric diagnosis)>66 ySerious (confounding)
       Díaz-Gegúndez
      • Díaz-Gegúndez M.
      • Paluzie G.
      • Sanz-Ballester C.
      • et al.
      Evaluación de un programa de intervención en residencias geriátricas para reducir la frecuentación hospitalaria.
      (2011)
      Nonrandomized interventionalNonrandomized controlled studyNursing homeSpain857 beds in interventional facilities (occupied by 1151 residents >3 y)

      1200 beds across the control facilities.
      Not reportedSerious (confounding)
       Gloth
      • Gloth 3rd, F.M.
      • Gloth M.J.
      A comparative effectiveness trial between a post-acute care hospitalist model and a community-based physician model of nursing home care.
      (2011)
      Nonrandomized interventionalControlled before/afterNursing homeUS2 nursing homes

      Intervention: 390 residents

      Control: 364 residents
      Mean (SD):

      Intervention: 75 (13)

      Control: 78 (13)
      Serious (measuring outcomes)
       Hutchinson
      • Hutchinson A.F.
      • Parikh S.
      • Tacey M.
      • et al.
      A longitudinal cohort study evaluating the impact of a geriatrician-led residential care outreach service on acute healthcare utilisation.
      (2015)
      Nonrandomized interventionalRetrospective cohort, interrupted time seriesResidential care facilitiesAustralia1327 patientsMean (SD):

      84 (8.01)
      Moderate
       Lisk
      • Lisk R.
      • Yeong K.
      • Nasim A.
      • et al.
      Geriatrician input into nursing homes reduces emergency hospital admissions.
      (2011)
      Nonrandomized interventionalNot stated (before/after study)Nursing homeUK3 care homes, part 1 (165 beds)

      3 care homes, part 2 (unknown number of beds)
      Not reportedSerious (confounding)
       McKee
      • McKee H.
      • Miller R.
      • Cuthbertson J.
      • et al.
      Nursing Home Outreach Clinics show an improvement in patient safety and reduction in hospital admissions in residents with chronic conditions.
      (2016)
      Nonrandomized interventionalService development and evaluationNursing homeUK50 patients reviewed in 12 nursing homesMean (SD):

      85.3 (9.7)
      Serious (confounding, classification of intervention)
       Monroe
      • Monroe T.
      • Carter M.
      • Parish A.
      A case study using the Beers List criteria to compare prescribing by family practitioners and geriatric specialists in a rural nursing home.
      (2011)
      ObservationalRetrospective chart audit, nonequivalent 2-group analysisNursing homeUS92Mean:

      81 y

      Geriatric-trained: 83

      Non–geriatric trained: 80
      Serious (confounding)
       Pittrow
      • Pittrow D.
      • Krappweis J.
      • Rentsch A.
      • et al.
      Pattern of prescriptions issued by nursing home-based physicians versus office-based physicians for frail elderly patients in German nursing homes.
      (2003)
      ObservationalRetrospective longitudinal studyNursing homeGermanyNursing home–based physician: 263

      Office-based physician: 733
      >60 ySerious (confounding)
       Schippinger
      • Schippinger W.
      • Hartinger G.
      • Hierzer A.
      • et al.
      Mobile geriatric consultant services for rest homes. Study of the effects of consultations by internal medicine specialists in the medical care of rest home residents.
      (2012)
      Nonrandomized interventionalControlled prospective observational studyRest home/nursing homeAustriaOne intervention (n = 168) and 1 control nursing home (n = 100)Mean:

      Control: 88 y

      Intervention: 89 y
      Moderate
       Tamura
      • Tamura B.K.
      • Bell C.L.
      • Lubimir K.
      • et al.
      Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes project.
      (2011)
      Nonrandomized interventionalQuality improvement study (before and after)Nursing home/skilled nursing facility/intermediate care facilityUSSingle center

      74 eligible participants but 2 died and 2 left the facility
      Mean:

      82.7 y
      Moderate
      Specialist nurse interventions
       Aigner
      • Aigner M.J.
      • Drew S.
      • Phipps J.
      A comparative study of nursing home resident outcomes between care provided by nurse practitioners/physicians versus physicians only.
      (2004)
      ObservationalRetrospective chart reviewNursing homesUS203 residents, 8 nursing homes

      Nurse practitioner/physician group: 132 (65%)

      Physician-only group: 71 (35%).
      Mean (SD):

      82 (9) y
      Serious (confounding, missing data)
       Bandurchin
      • Bandurchin A.
      • McNally M.J.
      • Ferguson-Pare M.
      Bringing back the house call: How an emergency mobile nursing service is reducing avoidable emergency department visits for residents in long-term care homes.
      (2011)
      Nonrandomized interventionalNot reported (before/after; uncontrolled)Long-term care homesCanada969 calls and visitsNot statedSerious (confounding and selection bias)
       Boyd
      • Boyd M.
      • Armstrong D.
      • Parker J.
      • et al.
      Do gerontology nurse specialists make a difference in hospitalization of long-term care residents? Results of a randomized comparison trial.
      (2014)
      Randomized trialRandomized controlled trialResidential aged careNew ZealandIntervention: 1425 beds

      Control: 1128 beds
      Mean (SD):

      Intervention: before 85 (6.8), after 84.3 (7.7)

      Control: before 85.5 (6.9), after 84.7 (6.5)
      See Figure 2
       Codde
      • Codde J.
      • Arendts G.
      • Frankel J.
      • et al.
      Transfers from residential aged care facilities to the emergency department are reduced through improved primary care services: An intervention study.
      (2010)
      Nonrandomized interventionalBefore/afterResidential aged care facilitiesAustralia503 episodes of careNot statedModerate
       El-Masri
      • El-Masri M.M.
      • Omar A.
      • Groh E.M.
      Evaluating the effectiveness of a nurse practitioner-led outreach program for long-term-care homes.
      (2015)
      Nonrandomized interventionalObservational prospective cohortLong-term care facilitiesCanada311 participants (total 1353 case presentations)Mean (SD):

      84.2 (9.37)
      Moderate
       Fan
      • Fan L.
      • Hou X.-Y.
      • Zhao J.
      • et al.
      Hospital in the Nursing Home program reduces emergency department presentations and hospital admissions from residential aged care facilities in Queensland, Australia: A quasi-experimental study.
      (2016)
      Nonrandomized interventional“Quasi-randomized”Residential aged care facilitiesAustraliaIntervention: 2127 beds before intervention, 2485 postintervention

      Control: 921 beds preintervention, 1313 postintervention
      95% participants >65 yModerate
       Kane
      • Kane R.L.
      • Keckhafer G.
      • Flood S.
      • et al.
      The effect of EverCare on hospital use.
      (2003)
      Nonrandomized interventionalQuasi-experimental posttest design, 2 control groupsNursing homesUSEverCare: 1936

      Control–in: 1123

      Control–out: 1745
      Mean (SD):

      EverCare: 83.7 (8.7)

      Control–in: 81.4 (11.9)

      Control–out: 84 (9.9)
      Moderate
       Kane
      • Kane R.L.
      • Flood S.
      • Bershadsky B.
      • Keckhafer G.
      Effect of an innovative medicare managed care program on the quality of care for nursing home residents.
      (2004)
      Nonrandomized interventionalNot stated (assumed to be same as above)Nursing homesUS6-mo assessments—EverCare: 399, Control–in: 996, Control–out: 1400

      12-mo assessments—EverCare: 606, Control–in: 918, Control–out: 1467

      18-mo assessments: EverCare: 664, Control–in: 855, Control–out: 1490
      Not statedModerate
       Klaasen
      • Klaasen K.
      • Lamont L.
      • Krishnan P.
      Setting a new standard of care in nursing homes.
      (2009)
      Nonrandomized interventionalNot reported (before/after)Nursing homeCanada116-bed nursing home“Generally over 85”Serious (confounding and reporting bias)
       Rantz
      • Rantz M.J.
      • Popejoy L.
      • Vogelsmeier A.
      • et al.
      Successfully reducing hospitalizations of nursing home residents: Results of the Missouri Quality Initiative.
      (2017)
      Nonrandomized interventionalProspective single-group interventionNursing homeUSTotal enrolled: 5168 (average enrolment: 1750/d)Median:

      82
      Serious (confounding)
       Street
      • Street M.
      • Considine J.
      • Livingston P.
      • et al.
      In-reach nursing services improve older patient outcomes and access to emergency care.
      (2015)
      Nonrandomized interventionalRetrospective cohort studyResidential aged care facilitiesAustraliaBefore = 2278 presentations to ED

      After = 2051
      Mean (SD):

      Before: 85.5 (7.1)

      After: 85.3 (7.1)
      Serious (confounding)
      Intervention without a specialist practitioner
       King
      • King M.A.
      • Roberts M.S.
      Multidisciplinary case conference reviews: Improving outcomes for nursing home residents, carers and health professionals.
      (2001)
      Nonrandomized interventionalBefore and after studyResidential aged care facilitiesAustraliaIntervention group: 76 medication review (75 patients as 1 patient was reviewed twice)Mean (median):

      All: 79.8 (82.3)

      Intervention (medication review): 78.9 (80.7)

      Control: 80.2 (83)
      Serious (selection bias)
      RCT, randomized controlled trial; SD, standard deviation; ROBINS, Risk Of Bias In Non-randomized Studies of Interventions.
      Also forms part of the specialist nurse category.
      Interventions, summarized in Table 2, are diverse, complex, and multifaceted, incorporating the input of geriatricians, geriatrician-led MDTs, nurse practitioners, geriatric nurse specialists, ED-trained nurses, and general practitioner–led MDTs. No studies of physician assistants were identified. All but one study
      • King M.A.
      • Roberts M.S.
      Multidisciplinary case conference reviews: Improving outcomes for nursing home residents, carers and health professionals.
      involved an intervention or exposure comprising a specialist practitioner, either a doctor or nurse, being compared against usual primary care. We define a specialist practitioner as a professional with a specific remit for older patients or nursing home residents, and/or specialist training (such a geriatrics) relevant to this patient population. Specialist practitioner is an umbrella term used to describe medically trained “specialist doctors” and “specialist nurses.” In all studies, the comparator group is the usual primary care provider. This is a primary care generalist in the majority of cases—either specifically stated,
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      • Codde J.
      • Arendts G.
      • Frankel J.
      • et al.
      Transfers from residential aged care facilities to the emergency department are reduced through improved primary care services: An intervention study.
      • Lisk R.
      • Yeong K.
      • Nasim A.
      • et al.
      Geriatrician input into nursing homes reduces emergency hospital admissions.
      • Schippinger W.
      • Hartinger G.
      • Hierzer A.
      • et al.
      Mobile geriatric consultant services for rest homes. Study of the effects of consultations by internal medicine specialists in the medical care of rest home residents.
      ascertained by contacting the authors
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      • Connolly M.J.
      • Broad J.B.
      • Boyd M.
      • et al.
      The “Big Five.” Hypothesis generation: A multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: A post hoc analysis of the ARCHUS cluster-randomised controlled trial.
      or deduced from knowledge of the health care system (for UK, Australian, and New Zealand studies).
      • Boyd M.
      • Armstrong D.
      • Parker J.
      • et al.
      Do gerontology nurse specialists make a difference in hospitalization of long-term care residents? Results of a randomized comparison trial.
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      • Fan L.
      • Hou X.-Y.
      • Zhao J.
      • et al.
      Hospital in the Nursing Home program reduces emergency department presentations and hospital admissions from residential aged care facilities in Queensland, Australia: A quasi-experimental study.
      • Hutchinson A.F.
      • Parikh S.
      • Tacey M.
      • et al.
      A longitudinal cohort study evaluating the impact of a geriatrician-led residential care outreach service on acute healthcare utilisation.
      • King M.A.
      • Roberts M.S.
      Multidisciplinary case conference reviews: Improving outcomes for nursing home residents, carers and health professionals.
      • McKee H.
      • Miller R.
      • Cuthbertson J.
      • et al.
      Nursing Home Outreach Clinics show an improvement in patient safety and reduction in hospital admissions in residents with chronic conditions.
      • Street M.
      • Considine J.
      • Livingston P.
      • et al.
      In-reach nursing services improve older patient outcomes and access to emergency care.
      However, it is clear that in 2 US studies,
      • Gloth 3rd, F.M.
      • Gloth M.J.
      A comparative effectiveness trial between a post-acute care hospitalist model and a community-based physician model of nursing home care.
      • Tamura B.K.
      • Bell C.L.
      • Lubimir K.
      • et al.
      Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes project.
      the usual primary care provider may also have training in geriatrics in addition to primary care training.
      Table 2Description of the Intervention, or Exposure, and Comparator Group for Included Studies
      Author/yearNature of the Intervention (Experimental Studies) or Exposure (for Observational Studies)CointerventionDescription of the Comparator
      Specialist doctor interventions
       Boorsma
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      (2011)
      Geriatric multidimensional assessment every 3 mo (web-based tool); care plan discussed with resident, family, family physician;

      twice-a-year MDT meetings for complex residents: family physician, nursing home physician, nurse, psychotherapist, and other disciplines
      Tool for comprehensive geriatric assessment

      Staff education
      Usual care from family physician
       Connolly (2015
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      and 2016
      • Connolly M.J.
      • Broad J.B.
      • Boyd M.
      • et al.
      The “Big Five.” Hypothesis generation: A multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: A post hoc analysis of the ARCHUS cluster-randomised controlled trial.
      )
      Also forms part of the specialist nurse category.
      Baseline facility assessment (gerontology nurse specialist); monitoring and benchmarking of resident indicators;

      three 1-h MDT meetings including medication review by the geriatrician, gerontology nurse specialists, GP, pharmacists, and nurse manager
      Gerontology nurse specialist performing staff education and coachingGPs (after clarification from authors)
       Crotty
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      (2004)
      Two multidisciplinary case conferences conducted 6-12 wk apart;

      GP formulated a problems list and did a medication review prior to the MDT;

      MDT GP (chair), geriatrician, pharmacist, care staff, representative of the Alzheimer's Association; problems discussed including behavioral problems
      Pharmacist, education sessions on challenging behaviorNot stated—presumed to be usual care
       D'Arcy
      • D'Arcy L.P.
      • Stearns S.C.
      • Domino M.E.
      • et al.
      Is geriatric care associated with less emergency department use?.
      (2013)
      GeriatricianNot statedFamily physician
       Díaz-Gegúndez
      • Díaz-Gegúndez M.
      • Paluzie G.
      • Sanz-Ballester C.
      • et al.
      Evaluación de un programa de intervención en residencias geriátricas para reducir la frecuentación hospitalaria.
      (2011)
      Three-year intervention: comprehensive geriatric assessments and follow-up visits for those patients with most complex needs, on a regular basis and on demand, regular meetings with medical and nursing staffExtended clinical investigations, staff training and protocol development, joint case management with specialistsUsual care (Spain)
       Gloth
      • Gloth 3rd, F.M.
      • Gloth M.J.
      A comparative effectiveness trial between a post-acute care hospitalist model and a community-based physician model of nursing home care.
      (2011)
      Geriatrician—acting as attending physician for at least 70% of residents and present in facility 3 times per weekAligning residents with 1 practitioner; nurse practitioner in the intervention (no attending duties)Community physicians, some with geriatrics training or internal medicine/family medicine
       Hutchinson
      • Hutchinson A.F.
      • Parikh S.
      • Tacey M.
      • et al.
      A longitudinal cohort study evaluating the impact of a geriatrician-led residential care outreach service on acute healthcare utilisation.
      (2015)
      Geriatrician-led multidisciplinary model of care including assessment, care planning, arrange interventions, referral to hospital in the home if required, develop long-term care plan with primary care, physician, and care home staffAged care specialist nurseNot stated—presumed to be usual care from GP
       Lisk
      • Lisk R.
      • Yeong K.
      • Nasim A.
      • et al.
      Geriatrician input into nursing homes reduces emergency hospital admissions.
      (2011)
      Geriatricians performed medical advisory meetings and clinical review with GPs and daily telephone adviceNurses providing extended treatment, eg, IV fluidGP
       McKee
      • McKee H.
      • Miller R.
      • Cuthbertson J.
      • et al.
      Nursing Home Outreach Clinics show an improvement in patient safety and reduction in hospital admissions in residents with chronic conditions.
      (2016)
      Consultant geriatrician doing outreach clinicsWorking with a pharmacistUsual care (UK)
       Monroe
      • Monroe T.
      • Carter M.
      • Parish A.
      A case study using the Beers List criteria to compare prescribing by family practitioners and geriatric specialists in a rural nursing home.
      (2011)
      Medical provider with geriatrics trainingNot statedGeneral family medicine training
       Pittrow
      • Pittrow D.
      • Krappweis J.
      • Rentsch A.
      • et al.
      Pattern of prescriptions issued by nursing home-based physicians versus office-based physicians for frail elderly patients in German nursing homes.
      (2003)
      Nursing home physician (presumed to be specialist doctors)Not statedOffice-based physicians
       Schippinger
      • Schippinger W.
      • Hartinger G.
      • Hierzer A.
      • et al.
      Mobile geriatric consultant services for rest homes. Study of the effects of consultations by internal medicine specialists in the medical care of rest home residents.
      (2012)
      Mobile consultant geriatric serviceInterventions normally delivered in hospitalGeneral practitioner
       Tamura
      • Tamura B.K.
      • Bell C.L.
      • Lubimir K.
      • et al.
      Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes project.
      (2011)
      Geriatricians and geriatric medicine fellows used tools, eg, Beers criteria, to identify potentially inappropriate medications; primary care physician contacted with recommendationsUse of the MDS QI instrumentNursing home primary care physician (frequently a faculty geriatrician)
      Specialist nurse interventions
       Boyd
      • Boyd M.
      • Armstrong D.
      • Parker J.
      • et al.
      Do gerontology nurse specialists make a difference in hospitalization of long-term care residents? Results of a randomized comparison trial.
      (2014)
      • Geriatric nurse specialist providing “proactive outreach,” consisting of:
        • 1.
          Clinical support (including bimonthly site visits, quality initiatives)
        • 2.
          Education and clinical coaching
        • 3.
          Care coordination for high-risk patients (including comprehensive geriatric assessment, liaison with specialists)
      As described to the leftUsual primary care provider (GP from knowledge of the health care system)
       Kane
      • Kane R.L.
      • Keckhafer G.
      • Flood S.
      • et al.
      The effect of EverCare on hospital use.
      (2003)

      Kane
      • Kane R.L.
      • Flood S.
      • Bershadsky B.
      • Keckhafer G.
      Effect of an innovative medicare managed care program on the quality of care for nursing home residents.
      (2004)
      Nurse practitioners: one-third time spent with clinical contact, one-fourth communicating with families, primary care physician; nurse practitioners also train the care home staffPayments for care home to deliver some hospital-level treatmentsUsual primary care
       Bandurchin
      • Bandurchin A.
      • McNally M.J.
      • Ferguson-Pare M.
      Bringing back the house call: How an emergency mobile nursing service is reducing avoidable emergency department visits for residents in long-term care homes.
      (2011)
      Registered nurses with expertise in geriatric care and emergency care working with the physician; visiting care homes to identify residents with health issues early;

      conducting rounds alongside care home nurses;

      performing assessment to identify signs of acute illness
      Education of care home staffNot stated—assumed to be usual care
       Klaasen
      • Klaasen K.
      • Lamont L.
      • Krishnan P.
      Setting a new standard of care in nursing homes.
      (2009)
      Nurse practitioner doing histories, physical examinations, diagnoses, managing acute illness and chronic disease, orders medication and investigations, performs minor proceduresNot detailedUsual primary care physician providing out-of-hours care
       Codde
      • Codde J.
      • Arendts G.
      • Frankel J.
      • et al.
      Transfers from residential aged care facilities to the emergency department are reduced through improved primary care services: An intervention study.
      (2010)
      Primary care service provided by ED-based nurses (not aged care training); direct clinical review/procedures for acute illness, eg, intravenous fluid, management of urine infection;

      education of staff was also provided
      Additional procedures normally associated with secondary carePre-existing model of GP care
       Fan
      • Fan L.
      • Hou X.-Y.
      • Zhao J.
      • et al.
      Hospital in the Nursing Home program reduces emergency department presentations and hospital admissions from residential aged care facilities in Queensland, Australia: A quasi-experimental study.
      (2016)
      ED-based nurses; components to the intervention: (1) Clinical staff allocated to manage acute illness in the care home; (2) Support and education for care staff and GPsEducation for the care home staffUsual care from GP
       Rantz
      • Rantz M.J.
      • Popejoy L.
      • Vogelsmeier A.
      • et al.
      Successfully reducing hospitalizations of nursing home residents: Results of the Missouri Quality Initiative.
      (2017)
      Advanced practice registered nurse—either nurse practitioner or clinical nurse specialistINTERACT tool, quality improvement, mentoring, and educationUsual care
       Street
      • Street M.
      • Considine J.
      • Livingston P.
      • et al.
      In-reach nursing services improve older patient outcomes and access to emergency care.
      (2015)
      Specialist practice nurses (supported by a geriatrician)—assessment when residents unwellGeriatrician support educationUsual care
       El-Masri
      • El-Masri M.M.
      • Omar A.
      • Groh E.M.
      Evaluating the effectiveness of a nurse practitioner-led outreach program for long-term-care homes.
      (2015)
      Nurse practitioners part of the ED team with independent treatment authorityNot statedMD (and registered nurse)
       Aigner
      • Aigner M.J.
      • Drew S.
      • Phipps J.
      A comparative study of nursing home resident outcomes between care provided by nurse practitioners/physicians versus physicians only.
      (2004)
      Nursing home nurse practitioner (acute visits, scheduled care, annual reviews)Not statedPhysician working alone
      Intervention without a specialist practitioner
       King
      • King M.A.
      • Roberts M.S.
      Multidisciplinary case conference reviews: Improving outcomes for nursing home residents, carers and health professionals.
      (2001)
      Three case conferences attended by GP, nursing staff, allied health care professionals, and a clinical pharmacistAllied health care professionals and a clinical pharmacistUsual care
      GP, general practitioner; INTERACT, Interventions to Reduce Acute Care Transfers program; IV, intravenous; MDS QI, Minimum Data Set Quality Indicator.
      Also forms part of the specialist nurse category.
      The most frequently encountered outcome was unplanned transfer to hospital, reported on 18 occasions,
      • D'Arcy L.P.
      • Stearns S.C.
      • Domino M.E.
      • et al.
      Is geriatric care associated with less emergency department use?.
      • Bandurchin A.
      • McNally M.J.
      • Ferguson-Pare M.
      Bringing back the house call: How an emergency mobile nursing service is reducing avoidable emergency department visits for residents in long-term care homes.
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      • Boyd M.
      • Armstrong D.
      • Parker J.
      • et al.
      Do gerontology nurse specialists make a difference in hospitalization of long-term care residents? Results of a randomized comparison trial.
      • Codde J.
      • Arendts G.
      • Frankel J.
      • et al.
      Transfers from residential aged care facilities to the emergency department are reduced through improved primary care services: An intervention study.
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      • Connolly M.J.
      • Broad J.B.
      • Boyd M.
      • et al.
      The “Big Five.” Hypothesis generation: A multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: A post hoc analysis of the ARCHUS cluster-randomised controlled trial.
      • Díaz-Gegúndez M.
      • Paluzie G.
      • Sanz-Ballester C.
      • et al.
      Evaluación de un programa de intervención en residencias geriátricas para reducir la frecuentación hospitalaria.
      • El-Masri M.M.
      • Omar A.
      • Groh E.M.
      Evaluating the effectiveness of a nurse practitioner-led outreach program for long-term-care homes.
      • Hutchinson A.F.
      • Parikh S.
      • Tacey M.
      • et al.
      A longitudinal cohort study evaluating the impact of a geriatrician-led residential care outreach service on acute healthcare utilisation.
      • Kane R.L.
      • Keckhafer G.
      • Flood S.
      • et al.
      The effect of EverCare on hospital use.
      • Klaasen K.
      • Lamont L.
      • Krishnan P.
      Setting a new standard of care in nursing homes.
      • Lisk R.
      • Yeong K.
      • Nasim A.
      • et al.
      Geriatrician input into nursing homes reduces emergency hospital admissions.
      • McKee H.
      • Miller R.
      • Cuthbertson J.
      • et al.
      Nursing Home Outreach Clinics show an improvement in patient safety and reduction in hospital admissions in residents with chronic conditions.
      • Rantz M.J.
      • Popejoy L.
      • Vogelsmeier A.
      • et al.
      Successfully reducing hospitalizations of nursing home residents: Results of the Missouri Quality Initiative.
      • Schippinger W.
      • Hartinger G.
      • Hierzer A.
      • et al.
      Mobile geriatric consultant services for rest homes. Study of the effects of consultations by internal medicine specialists in the medical care of rest home residents.
      • Street M.
      • Considine J.
      • Livingston P.
      • et al.
      In-reach nursing services improve older patient outcomes and access to emergency care.
      • Aigner M.J.
      • Drew S.
      • Phipps J.
      A comparative study of nursing home resident outcomes between care provided by nurse practitioners/physicians versus physicians only.
      followed by prescribing
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      • Gloth 3rd, F.M.
      • Gloth M.J.
      A comparative effectiveness trial between a post-acute care hospitalist model and a community-based physician model of nursing home care.
      • Kane R.L.
      • Flood S.
      • Bershadsky B.
      • Keckhafer G.
      Effect of an innovative medicare managed care program on the quality of care for nursing home residents.
      • King M.A.
      • Roberts M.S.
      Multidisciplinary case conference reviews: Improving outcomes for nursing home residents, carers and health professionals.
      • Klaasen K.
      • Lamont L.
      • Krishnan P.
      Setting a new standard of care in nursing homes.
      • McKee H.
      • Miller R.
      • Cuthbertson J.
      • et al.
      Nursing Home Outreach Clinics show an improvement in patient safety and reduction in hospital admissions in residents with chronic conditions.
      • Tamura B.K.
      • Bell C.L.
      • Lubimir K.
      • et al.
      Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes project.
      • Aigner M.J.
      • Drew S.
      • Phipps J.
      A comparative study of nursing home resident outcomes between care provided by nurse practitioners/physicians versus physicians only.
      • Monroe T.
      • Carter M.
      • Parish A.
      A case study using the Beers List criteria to compare prescribing by family practitioners and geriatric specialists in a rural nursing home.
      • Pittrow D.
      • Krappweis J.
      • Rentsch A.
      • et al.
      Pattern of prescriptions issued by nursing home-based physicians versus office-based physicians for frail elderly patients in German nursing homes.
      and mortality,
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      • Connolly M.J.
      • Broad J.B.
      • Boyd M.
      • et al.
      The “Big Five.” Hypothesis generation: A multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: A post hoc analysis of the ARCHUS cluster-randomised controlled trial.
      • Kane R.L.
      • Flood S.
      • Bershadsky B.
      • Keckhafer G.
      Effect of an innovative medicare managed care program on the quality of care for nursing home residents.
      • King M.A.
      • Roberts M.S.
      Multidisciplinary case conference reviews: Improving outcomes for nursing home residents, carers and health professionals.
      • Schippinger W.
      • Hartinger G.
      • Hierzer A.
      • et al.
      Mobile geriatric consultant services for rest homes. Study of the effects of consultations by internal medicine specialists in the medical care of rest home residents.
      reported on 11 and 6 occasions, respectively. There was a wide range of prescribing outcomes reported with minimal replication across multiple studies, although psychotropic medication prescribing was reported on 5 occasions,
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      • Kane R.L.
      • Flood S.
      • Bershadsky B.
      • Keckhafer G.
      Effect of an innovative medicare managed care program on the quality of care for nursing home residents.
      • King M.A.
      • Roberts M.S.
      Multidisciplinary case conference reviews: Improving outcomes for nursing home residents, carers and health professionals.
      • Klaasen K.
      • Lamont L.
      • Krishnan P.
      Setting a new standard of care in nursing homes.
      numbers of medication on 4 occasions,
      • Klaasen K.
      • Lamont L.
      • Krishnan P.
      Setting a new standard of care in nursing homes.
      • Tamura B.K.
      • Bell C.L.
      • Lubimir K.
      • et al.
      Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes project.
      • Aigner M.J.
      • Drew S.
      • Phipps J.
      A comparative study of nursing home resident outcomes between care provided by nurse practitioners/physicians versus physicians only.
      • Pittrow D.
      • Krappweis J.
      • Rentsch A.
      • et al.
      Pattern of prescriptions issued by nursing home-based physicians versus office-based physicians for frail elderly patients in German nursing homes.
      and medication appropriateness on 3 occasions.
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      • McKee H.
      • Miller R.
      • Cuthbertson J.
      • et al.
      Nursing Home Outreach Clinics show an improvement in patient safety and reduction in hospital admissions in residents with chronic conditions.
      • Monroe T.
      • Carter M.
      • Parish A.
      A case study using the Beers List criteria to compare prescribing by family practitioners and geriatric specialists in a rural nursing home.
      Four studies
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      • Gloth 3rd, F.M.
      • Gloth M.J.
      A comparative effectiveness trial between a post-acute care hospitalist model and a community-based physician model of nursing home care.
      • Kane R.L.
      • Flood S.
      • Bershadsky B.
      • Keckhafer G.
      Effect of an innovative medicare managed care program on the quality of care for nursing home residents.
      reported other quality indicators acknowledged as important for nursing home residents, such as falls and the presence of a urinary catheter, which are dependent on a range of other influences, such as nursing care. There were some noteworthy outcomes not reported, for example, chronic disease outcomes for key conditions, such as stroke, diabetes, hypertension, and heart failure.
      The Cochrane Risk of Bias tool
      was used to assess the randomized trials (Figure 2). There were 2 well-conducted cluster randomized studies across 3 publications.
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      • Connolly M.J.
      • Broad J.B.
      • Boyd M.
      • et al.
      The “Big Five.” Hypothesis generation: A multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: A post hoc analysis of the ARCHUS cluster-randomised controlled trial.
      However, the quality of the other cluster randomized
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      and patient-level randomized trials was low.
      • Boyd M.
      • Armstrong D.
      • Parker J.
      • et al.
      Do gerontology nurse specialists make a difference in hospitalization of long-term care residents? Results of a randomized comparison trial.
      Blinding of personnel or participants was not possible in any of the studies because of the nature of the intervention. According to the Cochrane ROBINS-I tool,

      Sterne JAC, Higgins JPT, Elbers RG, et al. Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I): Detailed guidance. Available at: https://www.bristol.ac.uk/media-library/sites/social-community-medicine/images/centres/cresyda/ROBINS-I_detailed_guidance.pdf. Accessed August 1, 2017.

      the nonrandomized studies had a moderate
      • Codde J.
      • Arendts G.
      • Frankel J.
      • et al.
      Transfers from residential aged care facilities to the emergency department are reduced through improved primary care services: An intervention study.
      • El-Masri M.M.
      • Omar A.
      • Groh E.M.
      Evaluating the effectiveness of a nurse practitioner-led outreach program for long-term-care homes.
      • Fan L.
      • Hou X.-Y.
      • Zhao J.
      • et al.
      Hospital in the Nursing Home program reduces emergency department presentations and hospital admissions from residential aged care facilities in Queensland, Australia: A quasi-experimental study.
      • Hutchinson A.F.
      • Parikh S.
      • Tacey M.
      • et al.
      A longitudinal cohort study evaluating the impact of a geriatrician-led residential care outreach service on acute healthcare utilisation.
      • Kane R.L.
      • Flood S.
      • Bershadsky B.
      • Keckhafer G.
      Effect of an innovative medicare managed care program on the quality of care for nursing home residents.
      • Kane R.L.
      • Keckhafer G.
      • Flood S.
      • et al.
      The effect of EverCare on hospital use.
      • Schippinger W.
      • Hartinger G.
      • Hierzer A.
      • et al.
      Mobile geriatric consultant services for rest homes. Study of the effects of consultations by internal medicine specialists in the medical care of rest home residents.
      • Tamura B.K.
      • Bell C.L.
      • Lubimir K.
      • et al.
      Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes project.
      or serious
      • D'Arcy L.P.
      • Stearns S.C.
      • Domino M.E.
      • et al.
      Is geriatric care associated with less emergency department use?.
      • Bandurchin A.
      • McNally M.J.
      • Ferguson-Pare M.
      Bringing back the house call: How an emergency mobile nursing service is reducing avoidable emergency department visits for residents in long-term care homes.
      • Díaz-Gegúndez M.
      • Paluzie G.
      • Sanz-Ballester C.
      • et al.
      Evaluación de un programa de intervención en residencias geriátricas para reducir la frecuentación hospitalaria.
      • Gloth 3rd, F.M.
      • Gloth M.J.
      A comparative effectiveness trial between a post-acute care hospitalist model and a community-based physician model of nursing home care.
      • King M.A.
      • Roberts M.S.
      Multidisciplinary case conference reviews: Improving outcomes for nursing home residents, carers and health professionals.
      • Klaasen K.
      • Lamont L.
      • Krishnan P.
      Setting a new standard of care in nursing homes.
      • Lisk R.
      • Yeong K.
      • Nasim A.
      • et al.
      Geriatrician input into nursing homes reduces emergency hospital admissions.
      • McKee H.
      • Miller R.
      • Cuthbertson J.
      • et al.
      Nursing Home Outreach Clinics show an improvement in patient safety and reduction in hospital admissions in residents with chronic conditions.
      • Rantz M.J.
      • Popejoy L.
      • Vogelsmeier A.
      • et al.
      Successfully reducing hospitalizations of nursing home residents: Results of the Missouri Quality Initiative.
      • Street M.
      • Considine J.
      • Livingston P.
      • et al.
      In-reach nursing services improve older patient outcomes and access to emergency care.
      • Aigner M.J.
      • Drew S.
      • Phipps J.
      A comparative study of nursing home resident outcomes between care provided by nurse practitioners/physicians versus physicians only.
      • Monroe T.
      • Carter M.
      • Parish A.
      A case study using the Beers List criteria to compare prescribing by family practitioners and geriatric specialists in a rural nursing home.
      • Pittrow D.
      • Krappweis J.
      • Rentsch A.
      • et al.
      Pattern of prescriptions issued by nursing home-based physicians versus office-based physicians for frail elderly patients in German nursing homes.
      risk of bias. Overall, the nonrandomized studies were of low quality, principally because of the potential for confounding.
      Figure thumbnail gr2
      Fig. 2Cochrane risk of bias results for randomized studies for each domain (+, low risk; –, high risk; ?, uncertain).

      Analysis Strategy

      The studies were grouped according to whether the intervention involved a specialist doctor or a specialist nurse. Although there was a high degree of heterogeneity in study setting and intervention, the heterogeneity was particularly marked for the outcomes reported. Within the most commonly reported outcome domain of unplanned hospital transfer, there was ambulance callouts, ED room attendance, admission to hospital, and length of stay. In addition, the way of measuring the same outcome varied widely. In the prescribing domain, there were 2 specialist doctor studies reporting psychotropic use, which was the most commonly used prescribing indicator. One study reported the use of antipsychotics
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      and the other used medication appropriateness index for benzodiazepines.
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      Overall, this heterogeneity meant that pooling would not have been possible for more than 2 studies reporting the same outcome and using sufficiently similar units of measurement. Hence, we performed a narrative synthesis.

      Interventions Involving a Specialist Doctor

      Ten publications with an experimental study design
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      • Connolly M.J.
      • Broad J.B.
      • Boyd M.
      • et al.
      The “Big Five.” Hypothesis generation: A multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: A post hoc analysis of the ARCHUS cluster-randomised controlled trial.
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      • Gloth 3rd, F.M.
      • Gloth M.J.
      A comparative effectiveness trial between a post-acute care hospitalist model and a community-based physician model of nursing home care.
      • Hutchinson A.F.
      • Parikh S.
      • Tacey M.
      • et al.
      A longitudinal cohort study evaluating the impact of a geriatrician-led residential care outreach service on acute healthcare utilisation.
      • Lisk R.
      • Yeong K.
      • Nasim A.
      • et al.
      Geriatrician input into nursing homes reduces emergency hospital admissions.
      • McKee H.
      • Miller R.
      • Cuthbertson J.
      • et al.
      Nursing Home Outreach Clinics show an improvement in patient safety and reduction in hospital admissions in residents with chronic conditions.
      • Schippinger W.
      • Hartinger G.
      • Hierzer A.
      • et al.
      Mobile geriatric consultant services for rest homes. Study of the effects of consultations by internal medicine specialists in the medical care of rest home residents.
      • Tamura B.K.
      • Bell C.L.
      • Lubimir K.
      • et al.
      Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes project.
      and 3 observational studies
      • D'Arcy L.P.
      • Stearns S.C.
      • Domino M.E.
      • et al.
      Is geriatric care associated with less emergency department use?.
      • Monroe T.
      • Carter M.
      • Parish A.
      A case study using the Beers List criteria to compare prescribing by family practitioners and geriatric specialists in a rural nursing home.
      • Pittrow D.
      • Krappweis J.
      • Rentsch A.
      • et al.
      Pattern of prescriptions issued by nursing home-based physicians versus office-based physicians for frail elderly patients in German nursing homes.
      compared an intervention, in which a specialist doctor is involved in delivering first-line primary care. There was a mixture of low- and moderate-quality studies; 3 well-conducted randomized trials,
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      • Connolly M.J.
      • Broad J.B.
      • Boyd M.
      • et al.
      The “Big Five.” Hypothesis generation: A multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: A post hoc analysis of the ARCHUS cluster-randomised controlled trial.
      one relatively low-quality RCT,
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      3 nonrandomized studies with a moderate risk of bias,
      • Hutchinson A.F.
      • Parikh S.
      • Tacey M.
      • et al.
      A longitudinal cohort study evaluating the impact of a geriatrician-led residential care outreach service on acute healthcare utilisation.
      • Schippinger W.
      • Hartinger G.
      • Hierzer A.
      • et al.
      Mobile geriatric consultant services for rest homes. Study of the effects of consultations by internal medicine specialists in the medical care of rest home residents.
      • Tamura B.K.
      • Bell C.L.
      • Lubimir K.
      • et al.
      Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes project.
      4 with a serious risk of bias
      • Díaz-Gegúndez M.
      • Paluzie G.
      • Sanz-Ballester C.
      • et al.
      Evaluación de un programa de intervención en residencias geriátricas para reducir la frecuentación hospitalaria.
      • Gloth 3rd, F.M.
      • Gloth M.J.
      A comparative effectiveness trial between a post-acute care hospitalist model and a community-based physician model of nursing home care.
      • Lisk R.
      • Yeong K.
      • Nasim A.
      • et al.
      Geriatrician input into nursing homes reduces emergency hospital admissions.
      • McKee H.
      • Miller R.
      • Cuthbertson J.
      • et al.
      Nursing Home Outreach Clinics show an improvement in patient safety and reduction in hospital admissions in residents with chronic conditions.
      and 3 observational studies with a serious risk of bias.
      • D'Arcy L.P.
      • Stearns S.C.
      • Domino M.E.
      • et al.
      Is geriatric care associated with less emergency department use?.
      • Monroe T.
      • Carter M.
      • Parish A.
      A case study using the Beers List criteria to compare prescribing by family practitioners and geriatric specialists in a rural nursing home.
      • Pittrow D.
      • Krappweis J.
      • Rentsch A.
      • et al.
      Pattern of prescriptions issued by nursing home-based physicians versus office-based physicians for frail elderly patients in German nursing homes.
      One specialist doctor intervention involved a nursing home physician,
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      whereas all of the rest were based on a geriatrician. The aim of the interventions was to supplement, rather than supplant, the existing primary care model. The interventions were complex and involved more than simply supplementing usual care with a specialist doctor. Co-interventions were wide-ranging, as shown in Table 2, and included specialist nurses,
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      • Connolly M.J.
      • Broad J.B.
      • Boyd M.
      • et al.
      The “Big Five.” Hypothesis generation: A multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: A post hoc analysis of the ARCHUS cluster-randomised controlled trial.
      • Gloth 3rd, F.M.
      • Gloth M.J.
      A comparative effectiveness trial between a post-acute care hospitalist model and a community-based physician model of nursing home care.
      • Hutchinson A.F.
      • Parikh S.
      • Tacey M.
      • et al.
      A longitudinal cohort study evaluating the impact of a geriatrician-led residential care outreach service on acute healthcare utilisation.
      extended treatment options,
      • Lisk R.
      • Yeong K.
      • Nasim A.
      • et al.
      Geriatrician input into nursing homes reduces emergency hospital admissions.
      • Schippinger W.
      • Hartinger G.
      • Hierzer A.
      • et al.
      Mobile geriatric consultant services for rest homes. Study of the effects of consultations by internal medicine specialists in the medical care of rest home residents.
      a multidimensional assessment tool,
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      staff education,
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      • Connolly M.J.
      • Broad J.B.
      • Boyd M.
      • et al.
      The “Big Five.” Hypothesis generation: A multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: A post hoc analysis of the ARCHUS cluster-randomised controlled trial.
      and a clinical pharmacist in the MDT.
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      • McKee H.
      • Miller R.
      • Cuthbertson J.
      • et al.
      Nursing Home Outreach Clinics show an improvement in patient safety and reduction in hospital admissions in residents with chronic conditions.
      The comparator group is the usual primary care provider in all studies. There were 2 occasions when the normal primary care provider appeared to have generalist and specialist geriatrics training,
      • Gloth 3rd, F.M.
      • Gloth M.J.
      A comparative effectiveness trial between a post-acute care hospitalist model and a community-based physician model of nursing home care.
      • Tamura B.K.
      • Bell C.L.
      • Lubimir K.
      • et al.
      Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes project.
      which would tend to attenuate the observed effect of the intervention. There was a spectrum of collaborative working, ranging from formal MDTs incorporating geriatricians
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      • Connolly M.J.
      • Broad J.B.
      • Boyd M.
      • et al.
      The “Big Five.” Hypothesis generation: A multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: A post hoc analysis of the ARCHUS cluster-randomised controlled trial.
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      to less formal arrangements.
      The main findings from interventions involving a specialist doctor are summarized in Figure 3 (and detailed in supplementary online material). First, although the majority of studies showed specialist doctor input to be associated with reduced unplanned hospital transfer, the 2 well-conducted randomized trials conducted by Boorsma
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      and Connolly
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      did not find a positive association. However, Connolly
      • Connolly M.J.
      • Broad J.B.
      • Boyd M.
      • et al.
      The “Big Five.” Hypothesis generation: A multidisciplinary intervention package reduces disease-specific hospitalisations from long-term care: A post hoc analysis of the ARCHUS cluster-randomised controlled trial.
      did subsequently report improvements in hospital admission specifically for 5 common conditions in a post hoc analysis. Second, a consistent association with improved prescribing practice was demonstrated. This reaches statistical significance in 2 randomized trials,
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      • Crotty M.
      • Halbert J.
      • Rowett D.
      • et al.
      An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing.
      one nonrandomized interventional study,
      • Tamura B.K.
      • Bell C.L.
      • Lubimir K.
      • et al.
      Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes project.
      and 2 observational studies.
      • Monroe T.
      • Carter M.
      • Parish A.
      A case study using the Beers List criteria to compare prescribing by family practitioners and geriatric specialists in a rural nursing home.
      • Pittrow D.
      • Krappweis J.
      • Rentsch A.
      • et al.
      Pattern of prescriptions issued by nursing home-based physicians versus office-based physicians for frail elderly patients in German nursing homes.
      Third, specialist doctor interventions were not associated with improvements in mortality.
      • Boorsma M.
      • Frijters D.H.
      • Knol D.L.
      • et al.
      Effects of multidisciplinary integrated care on quality of care in residential care facilities for elderly people: A cluster randomized trial.
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.
      • Schippinger W.
      • Hartinger G.
      • Hierzer A.
      • et al.
      Mobile geriatric consultant services for rest homes. Study of the effects of consultations by internal medicine specialists in the medical care of rest home residents.
      Figure thumbnail gr3
      Fig. 3Impact of exposures or interventions of specialist practitioners (doctors above and nurses below) compared to the usual primary care.

      Interventions Involving a Specialist Nurse

      Twelve publications with an experimental study design
      • Bandurchin A.
      • McNally M.J.
      • Ferguson-Pare M.
      Bringing back the house call: How an emergency mobile nursing service is reducing avoidable emergency department visits for residents in long-term care homes.
      • Boyd M.
      • Armstrong D.
      • Parker J.
      • et al.
      Do gerontology nurse specialists make a difference in hospitalization of long-term care residents? Results of a randomized comparison trial.
      • Codde J.
      • Arendts G.
      • Frankel J.
      • et al.
      Transfers from residential aged care facilities to the emergency department are reduced through improved primary care services: An intervention study.
      • Connolly M.J.
      • Boyd M.
      • Broad J.B.
      • et al.
      The Aged Residential Care Healthcare Utilization Study (ARCHUS): A multidisciplinary, cluster randomized controlled trial designed to reduce acute avoidable hospitalizations from long-term care facilities.