In the article “Antihypertensive Medication Regimen Intensity and Incident Dementia
in an Older Population” by Tan et al, the authors reported that in a prospective observational population-based
cohort of 1208 older persons (mean age: 84.1 ± 5.6), use of a higher number of antihypertensive
drug (AHD) classes was associated with a lower dementia risk during 6 years of follow-up.
1
Cox regression was used to estimate hazard ratios (HRs), and competing risk of death
was adjusted for using the subdistribution hazard method of Fine and Gray.
2
The authors concluded that use of multiple AHD classes may convey a reduced dementia
risk. This novel finding could have important clinical implications, making replication
imperative.To read this article in full you will need to make a payment
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References
- Antihypertensive medication regimen intensity and incident dementia in an older population.J Am Med Dir Assoc. 2018; 19: 577-583
- A proportional hazards model for the subdistribution of a competing risk.J Am Stat Assoc. 1999; 94: 496-509
- Lower dementia risk with different classes of antihypertensive medication in older patients.J Hypertens. 2017; 35: 2095-2101
- Practical recommendations for reporting Fine-Gray model analyses for competing risk data.Stat Med. 2017; 36: 4391-4400
- Interpreting and comparing risks in the presence of competing events.BMJ. 2014; 349: g5060
- 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults.Hypertension. 2018; 12: 579.e1-579.e73
Article info
Footnotes
Funded by the Dutch Ministry of Health,Welfare and Sport; Dutch Innovation Fund of Collaborative Healthy Insurances; Netherlands Organisation for Health Research and Development. The authors declare no conflicts of interest.
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Copyright
© 2018 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
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Access this article on ScienceDirectLinked Article
- Response to the Letter to the Editor: “Antihypertensive Medication Regimen Intensity and Incident Dementia in an Older Population”Journal of the American Medical Directors AssociationVol. 19Issue 11
