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Letter to the Editor| Volume 19, ISSUE 11, P1028-1029, November 2018

Response to the Letter to the Editor: “Antihypertensive Medication Regimen Intensity and Incident Dementia in an Older Population”

  • Edwin C.K. Tan
    Affiliations
    Center for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia
    Aging Research Center, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden
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  • Chengxuan Qiu
    Affiliations
    Aging Research Center, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden
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  • J. Simon Bell
    Affiliations
    Center for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia
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  • Kristina Johnell
    Affiliations
    Aging Research Center, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden
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      We thank the authors for their comments regarding our recent study on antihypertensive regimen intensity and incident dementia in an older Swedish population.
      • Tan E.C.K.
      • Qiu C.
      • Liang Y.
      • et al.
      Antihypertensive medication regimen intensity and incident dementia in an older population.
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      References

        • Tan E.C.K.
        • Qiu C.
        • Liang Y.
        • et al.
        Antihypertensive medication regimen intensity and incident dementia in an older population.
        J Am Med Dir Assoc. 2018; 19: 577-583
        • van Middelaar T.
        • van Vught L.A.
        • van Charante E.P.M.
        • et al.
        Lower dementia risk with different classes of antihypertensive medication in older patients.
        J Hypertens. 2017; 35: 2095-2101
        • Kheirbek R.E.
        Hypertension treatment controversies in the oldest old.
        Am J Med. 2018; 131: 335-336
        • Gerhard T.
        Bias: Considerations for research practice.
        Am J Health Syst Pharm. 2008; 65: 2159-2168

      Linked Article

      • Antihypertensive Drugs, Incident Dementia, and the Competing Risk of Death
        Journal of the American Medical Directors AssociationVol. 19Issue 11
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          In the article “Antihypertensive Medication Regimen Intensity and Incident Dementia in an Older Population” by Tan et al, the authors reported that in a prospective observational population-based cohort of 1208 older persons (mean age: 84.1 ± 5.6), use of a higher number of antihypertensive drug (AHD) classes was associated with a lower dementia risk during 6 years of follow-up.1 Cox regression was used to estimate hazard ratios (HRs), and competing risk of death was adjusted for using the subdistribution hazard method of Fine and Gray.
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