Advertisement
Review Article| Volume 21, ISSUE 8, P1036-1044, August 2020

Effectiveness of Intervention Based on End-effector Gait Trainer in Older Patients With Stroke: A Systematic Review

Published:November 28, 2019DOI:https://doi.org/10.1016/j.jamda.2019.10.010

      Abstract

      Objective

      The objective of the article is to analyze the effects of the end-effector technology for gait rehabilitation on acute, subacute, and chronic stroke in order to verify the efficacy of the treatment in older people, based on evidence from randomized controlled trials, and thus increase the clinical knowledge for future applications in the hospital setting.

      Design

      A systematic review of the literature was conducted in October 2018. The data were collected from Cochrane, Embase, Scopus, and PubMed databases, analyzing manuscripts and articles of the last 10 years.

      Setting

      We included only randomized controlled trials written in English and aimed to study the effects of end-effector devices in improving walking in stroke patients. We selected 20 studies, and the results were divided into subacute stroke patients and chronic stroke patients.

      Measures

      Quality evaluation was performed using the PEDro scale. Of the 10 studies considered, 9 were randomized controlled trials. The PEDro scale score ranged from 7 to 10.

      Results

      Robotic-assisted gait trainer is more effective for subacute stroke patients with a lower function ambulation assessment, showing significant changes in independent walking ability. One possible explanation of the improvement of the gait speed and functional ambulation is the opportunity of receiving a more intensive and repetitive task-oriented training through end-effector robotic-based intervention.

      Conclusions and Implications

      The use of robotic-assisted gait trainer, together with a conventional treatment, seems to improve the walking capability of patients. Future research trials should take into account the impact of the robotic end-effector gait training on the oldest population, as this target was only partially included in the studies examined. Availability of new evidence will support the design of innovative assistive models for the clinical rehabilitation setting, which will take into account the need of personalizing the intervention to support the growing oldest old population.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Journal of the American Medical Directors Association
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • World Health Organization
        The World Health Report 2002: Reducing Risks, Promoting Healthy Life.
        World Health Organization, Geneva2002
        • UN Department of Economic and Social Affairs
        World Population Prospects: The 2017 Revision.
        UN Department of Economic and Social Affairs, New York2017
        • Truelsen T.
        • Piechowski-Jozwiak B.
        • Bonita R.
        • et al.
        Stroke incidence and prevalence in Europe: A review of available data.
        Eur J Neurol. 2006; 13: 581-598
        • Ovbiagele B.
        • Nguyen-Huynh M.N.
        Stroke epidemiology: Advancing our understanding of disease mechanism and therapy.
        Neurotherapeutics. 2011; 8: 319-329
        • Truelsen T.
        • Mahonen M.
        • Tolenen H.
        • et al.
        Trends in stroke and coronary heart diseases in the WHO MONICA Project.
        Stroke. 2003; 34: 1346-1352
        • Taveggia G.
        • Bordoni A.
        • Mulé C.
        • et al.
        Conflicting results of robot-assisted versus usual gait training during postacute rehabilitation of stroke patients: A randomized clinical trial.
        Int J Rehabil Res. 2016; 39: 29-35
        • Molteni F.
        • Gasperini G.
        • Cannaviello G.
        • Guanziroli E.
        Exoskeleton and end-effector for upper and lower limbs rehabilitation: Narrative review.
        PM R. 2018; 10: S174-S188
        • Apte S.
        • Plooij M.
        • Vallery H.
        Influence of body weight unloading on human gait characteristics: A systematic review.
        J Neuroeng Rehabil. 2018; 15: 53
        • Van Kammen K.
        • Boonstra A.
        • Reinders-Messelink H.
        • den Otter R.
        The combined effects of body weight support and gait speed on gait related muscle activity: A comparison between walking in the Lokomat exoskeleton and regular treadmill walking.
        PLoS One. 2014; 9: 9
        • Veneman J.F.
        • Kruidhof R.
        • Hekman E.E.
        • et al.
        Design and evaluation of the LOPES exoskeleton robot for interactive gait rehabilitation.
        IEEE Trans Neural Syst Rehabil Eng. 2007; 15: 379-386
        • Banala S.K.
        • Kim S.H.
        • Agrawal S.K.
        • Scholz J.P.
        Robot assisted gait training with active leg exoskeleton (ALKEX).
        IEEE Trans Neural Syst Rehabil Eng. 2009; 17: 2-8
        • Hesse S.
        • Waldner A.
        • Tomelleri C.
        Innovative gait robot for the repetitive practice of floor walking and stair climbing up and down in stroke patients.
        J Neuroeng Rehabil. 2010; 7: 30
        • Chen G.
        • Chan C.K.
        • Guo Z.
        • Yu H.
        A review of lower extremity assistive robotic exoskeletons in rehabilitation therapy.
        Crit Rev Biomed Eng. 2013; 41: 343-363
        • Molteni F.
        • Gasperini G.
        • Gaffuri M.
        • et al.
        Wearable robotic exoskeleton for overground gait training in sub-acute and chronic hemiparetic stroke patients: Preliminary results.
        Eur J Phys Rehabil Med. 2017; 53: 676-684
        • Louie D.R.
        • Eng J.J.
        Powered robotic exoskeletons in poststroke rehabilitation of gait: A scoping review.
        J Neuroeng Rehabil. 2016; 13: 53
        • Huysamen K.
        • de Looze M.
        • Bosch T.
        • et al.
        Assessment of an active industrial exoskeleton to aid dynamic lifting and lowering manual handling tasks.
        Appl Ergon. 2018; 68: 125-131
        • Schwartz I.
        • Meiner Z.
        Robot-assisted gait training in neurological patient: Who may benefit?.
        Ann Biomed Eng. 2015; 43: 1260-1269
        • Mazzoleni S.
        • Focacci A.
        • Franceschini M.
        • et al.
        Robot-assisted end-effector-based gait training in chronic stroke patients: A multicentric uncontrolled observational retrospective clinical study.
        NeuroRehabilitation. 2017; 40: 483-492
        • Galli M.
        • Cimolin V.
        • De Pandis M.F.
        • et al.
        Robot-assisted gait training versus treadmill training in patients with Parkinson’s disease: A kinematic evaluation with gait profile score.
        Funct Neurol. 2016; 31: 163-170
        • Sale P.
        • Stocchi F.
        • Galafate D.
        • et al.
        Effects of robot assisted gait training in progressive supranuclear palsy (PSP): A preliminary report.
        Front Hum Neurosci. 2014; 8: 207
        • Esquenazi A.
        • Lee S.
        • Wikoff A.
        • et al.
        A comparison of locomotor therapy interventions: Partial-body weight-supported treadmill, Lokomat, and G-EO training in people with traumatic brain injury.
        Am J Phys Med Rehabil. 2017; 9: 839-846
        • Babaiasl M.
        • Mahdioun S.H.
        • Jaryani P.
        • Yazdani M.
        A review of technological and clinical aspects of robot-aided rehabilitation of upper-extremity after stroke.
        Disabil Rehabil Assist Technol. 2016; 11: 263-280
        • Cho J.E.
        • Yoo J.S.
        • Kim K.E.
        • et al.
        Systematic review of appropriate robotic intervention for gait function in subacute stroke patients.
        BioMed Res Int. 2018; 2018
        • Bruni M.F.
        • Melegari C.
        • De Cola M.C.
        • et al.
        What does best evidence tell us about robotic gait rehabilitation in stroke patients: A systematic review and meta-analysis.
        J Clin Neurosci. 2018; 48: 11-17
        • Mehrlolz J.
        • Pohl M.
        • Kugler J.
        • Elsner B.
        The improvement of walking ability following stroke.
        Medicine. 2018; 115: 639-645
        • Chang W.H.
        • Kim Y.H.
        Robot-assisted therapy in stroke rehabilitation.
        J Stroke. 2013; 15: 174-181
        • Hesse S.
        • Schattat N.
        • Mehrholz J.
        • Wernwr C.
        Evidence of end-effector based gait machines in gait rehabilitation after CNS lesion.
        NeuroRehabilitation. 2013; 33: 77-84
        • Mehrholz J.
        • Pohl M.
        Electromechanical-assisted gait training after a systematic review comparing end-effector and exoskeleton devices.
        J Rehabil Med. 2012; 44: 193-199
        • Sale P.
        • Franceschini M.
        • Waldner A.
        • Hesse S.
        Use of the robot assisted gait therapy in rehabilitation of patients with stroke and spinal cord injury.
        Eur J Phys Rehabil Med. 2012; 48: 111-121
        • Hesse S.
        • Mehrholz J.
        • Wernwr C.
        Robot-assisted upper and lower limb rehabilitation after stroke.
        Dtsch Arztebl Int. 2008; 105: 330-336
        • Morone G.
        • Iosa M.
        • Bragoni M.
        • et al.
        Who may have durable benefit from robotic gait training? A 2-years follow-up randomized controlled trial in patients with subacute stroke.
        Stroke. 2012; 43: 1140-1142
        • Lin L.F.
        • Huang S.W.
        • Chang K.H.
        • et al.
        A novel robotic gait training system (RGTS) may facilitate functional recovery after stroke: A feasibility and safety study.
        NeuroRehabilitation. 2017; 41: 453-461
        • Hesse S.
        • Tomelleri C.
        • Bardeleben A.
        • et al.
        Robot-assisted practice of gait and stair climbing in nonambulatory stroke patients.
        J Rehabil Res Dev. 2012; 49: 613-622
        • Morone G.
        • Bragoni M.
        • Iosa M.
        • et al.
        Who may benefit from robotic-assisted gait training? A randomized clinical trial in patients with subacute stroke.
        Neurorehabil Neural Repair. 2011; 25: 636-644
        • Peurala S.H.
        • Airaksinen O.
        • Huuskonen P.
        • et al.
        Effects of intensive therapy using gait trainer or floor walking exercises early after stroke.
        J Rehabil Med. 2009; 41: 166-173
        • Pohl M.
        • Werner C.
        • Holzgraefe M.
        • et al.
        Repetitive locomotor training and physiotherapy improve walking and basic activities of daily living after stroke: A single-blind, randomized multicentre trial (DEutsche GAngtrainerStudie, DEGAS).
        Clin Rehabil. 2007; 21: 17-27
        • Ng M.F.
        • Tong R.K.
        • Li L.S.
        A pilot study of randomized clinical controlled trial of gait training in subacute stroke patients with partial body-weight support electromechanical gait trainer and functional electrical stimulation: Six-month follow-up.
        Stroke. 2008; 39: 154-160
        • Dias D.
        • Laíns J.
        • Pereira A.
        • et al.
        Can we improve gait skills in chronic hemiplegics? A randomised control trial with gait trainer.
        Eura Medicophys. 2007; 43: 499-504
        • Tong R.K.
        • Ng M.F.
        • Li L.S.
        Effectiveness of gait training using an electromechanical gait trainer, with and without functional electric stimulation, in subacute stroke: A randomized controlled trial.
        Arch Phys Med Rehabil. 2006; 87: 1298-1304
        • Peurala S.H.
        • Tarkka I.M.
        • Pitkänen K.
        • Sivenius J.
        The effectiveness of body weight-supported gait training and floor walking in patients with chronic stroke.
        Arch Phys Med Rehabil. 2005; 86: 1557-1564
        • Maher C.G.
        • Sherrington C.
        • Herbert R.D.
        • et al.
        Reliability of the PEDro scale for rating quality of randomized controlled trials.
        Phys Ther. 2003; 83: 713-721
        • Morone G.
        • Paolucci S.
        • Cherubini A.
        • et al.
        Robot-assisted gait training for stroke patients: Current state of the art and perspectives of robotics.
        Neuropsychiatr Dis Treat. 2017; 13: 1303-1311
        • Peters S.
        • Handy T.C.
        • Lakhani B.
        • et al.
        Motor and visuospatial attention and motor planning after stroke: Considerations for the rehabilitation of standing balance and gait.
        Phys Ther. 2015; 95: 1423-1432
        • Lattanzio F.
        • Abbatecola A.M.
        • Bevilacqua R.
        • et al.
        Advanced technology care innovation for older people in Italy: Necessity and opportunity.
        J Am Med Dir Assoc. 2014; 15: 457-466
        • Shafiee G.
        • Keshtkar A.
        • Soltani A.
        • et al.
        Prevalence of sarcopenia in the world: A systematic review and meta-analysis of general population studies.
        J Diabetes Metab Disord. 2017; 16: 16-21