Abstract
Objective
Despite the wide usage of the National Institute of Neurological Disorders and Stroke
and Canadian Stroke Network (NINDS-CSN) neuropsychological battery for the detection
of vascular cognitive impairment, its reliability and validity have not been established.
Therefore, the present study established the psychometric properties of the battery
in cognitively normal older adults in a clinical setting in Singapore.
Design
Longitudinal study.
Setting and Participants
A total of 105 cognitively normal older adults age 50 years and older were assessed
in a memory clinic setting.
Methods
The 60-minute NINDS-CSN and 5-minute protocol were administered to participants at
baseline and 3-month follow-up. Raw scores were transformed into standardized z scores. Test-retest reliability, concurrent validity and construct (convergent and
discriminant) validity were reported.
Results
Moderate-to-excellent test-retest reliability (r = 0.36–0.87), concurrent validity, and construct validity (r = 0.41–0.83) were found in both protocols over 3 months (all Ps < 0.01). Although the 5-minute protocol showed moderate validity (r = 0.41), the 60-minute protocol had excellent concurrent validity against a locally
validated neuropsychological battery (r = 0.83).
Conclusion and Implications
The NINDS-CSN is reliable and valid in assessing cognitive function. The 60-minute
protocol demonstrates great utility beyond its current usage in vascular cognitive
impairment populations to the general older adult population. The 5-minute protocol
can be used as a brief cognitive screening tool in primary healthcare and the community,
due to its brevity and accuracy. Future research should further examine the generalizability
of the NINDS-CSN battery in other dementias and cognitive disorders.
Keywords
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Article info
Publication history
Published online: May 19, 2020
Footnotes
This study was supported by the Singapore National Medical Research Council center grants NMRC/NUHS/2010 (project No. R-184-006-184-511) and NMRC/CG/013/2013.
The authors declare no conflicts of interest.
Identification
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© 2020 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
