Older people are susceptible to the adverse effects of anticholinergic medications,
including cognitive impairment.
1
A systematic review of observational studies reported mixed associations between
high anticholinergic burden, a cumulative measure of anticholinergic medications,
and cognitive performance in older people.
2
Observational studies may have biased estimates of the impact of exposures, as the
exposed and unexposed may systematically differ in covariates associated with the
outcomes.
3
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References
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Article info
Publication history
Published online: May 10, 2020
Footnotes
H.A. was supported by the National Institute on Aging (R01AG047891-01A1, P50AG047270, and P30AG021342-16S1); in addition, H.A. and L.H. received support from the National Institute on Aging Yale Claude D. Pepper Older Americans Independence Center (P30AG021342).
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Copyright
© 2020 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
