Abstract
Objective
This study aimed to characterize the biomarker profile of sarcopenic vs nonsarcopenic
men and women, using the current European Working Group on Sarcopenia in Older People
(EWGSOP2) definition in the UK Biobank study.
Design
Cross-sectional study.
Setting and Participants
A total of 396,707 (68.8% women, age 38 to 73) participants from UK Biobank.
Measures
Thirty-three biomarkers, standardized to sex-specific z-scores, were included in the analysis. Associations between these biomarkers and
sarcopenia, defined using EWGSOP2 criteria, were examined using multiple linear regression.
Results
Higher concentrations of rheumatoid factor, C-reactive protein, cystatin C, sex hormone-binding
globulin, gamma-glutamyltransferase, alkaline phosphatase, and total protein, as well
as lower concentrations of insulin-like growth factor-1, albumin, creatinine, sodium,
and systolic blood pressure, were associated with sarcopenia in both men and women.
However, some of the associations differed by sex. Sarcopenia was associated with
higher concentrations of phosphate, lipoprotein A, and lower of diastolic blood pressure,
HbA1c, urea, glucose, total bilirubin, and testosterone in women only, and with higher
concentrations of high-density lipoprotein, aspartate aminotransferase, and direct
bilirubin and lower values of apolipoprotein A, vitamin D, and apolipoprotein B in
men only.
Conclusions and Implications
Several biomarkers were associated with sarcopenia in men and women using the new
EWGSOP2 statement. However, some of these associations and their magnitude differed
between men and women. Considering the EWGSOP2 updated its statement on the definition
of sarcopenia in 2019, this study enables us to update the study of the biomarkers
profile of people with sarcopenia.
Keywords
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Article info
Publication history
Published online: July 05, 2020
Footnotes
J.P.P., C.C.M., and F.K.H. contributed equally to this work and are joint senior authors.
The authors declare no conflicts of interest.
UK Biobank was established by the Wellcome Trust medical charity, Medical Research Council, Department of Health, Scottish Government and the Northwest Regional Development Agency. It has also had funding from the Welsh Assembly Government and the British Heart Foundation. All authors had final responsibility for submission for publication. FP-R receives financial support from the Chilean Government for doing her PhD (ANID-Becas Chile).
Identification
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© 2020 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
