Abstract
Objectives
To evaluate the efficacy of daily consumption of fortified yogurt with beta-Hydroxy
beta-Methyl Butyrate (HMB) and vitamins D and C on measures of sarcopenia, inflammation,
and quality of life in sarcopenic older adults.
Design
In this 12-week randomized double-blind controlled trial, participants received either
yogurt fortified with 3 g HMB, 1000 IU vitamin D, and 500 mg vitamin C in the intervention
group (n = 33) or plain yogurt in the control group (n = 33).
Setting and Participants
A total of 66 older adults with sarcopenia recruited from the community in Shiraz,
Iran.
Measures
Body composition, muscle strength, and functionality were measured using Dual-energy-X-ray
Absorptiometry (DXA), hydraulic handgrip dynamometer, and usual gait speed, respectively.
Serum concentrations of vitamin D, insulin-like growth factor-1 (IGF-1), C-reactive
protein (hs-CRP), malondialdehyde, and insulin were measured at baseline and after
12 weeks. Health-related quality of life (HRQoL) was also evaluated using SF-12 questionnaire.
Results
Consumption of fortified yogurt was associated with improvement in handgrip strength
[mean change (95% confidence interval) 4.36 (3.35–5.37) vs. 0.97 (−0.04 to 1.99)]
and gait speed [0.10 (0.07–0.13) vs. 0.01 (0.00–0.04)] in the intervention group compared
with the control group (P < .001). In addition, the results revealed a significant increase in vitamin D and
IGF-1 levels in the intervention group (P < .001). The nutritional intervention significantly prevented any increase in the
serum concentration of hs-CRP compared with the control group (P = .033). The results also showed a more significant decrease in the malondialdehyde
level in the intervention group compared with the control (P = .008). Moreover, there were significant differences between the 2 groups regarding
physical aspects of HRQoL (P = .035).
Conclusions and Implications
A novel dairy product fortified with HMB, vitamin D, and vitamin C not only could
enhance muscle strength and functionality, but also modulate anabolic and inflammatory
conditions as well as quality of life. This study suggested that specific nutritional
interventions alone could be beneficial, especially for those who are unable to exercise.
Keywords
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Article info
Publication history
Published online: October 13, 2020
Footnotes
The authors declare no conflicts of interest.
This work was supported by Shiraz University of Medical Sciences (grant No. 8714633) in collaboration with School of Nutrition and Endocrinology and Metabolic Research Institute.
The local Medical Ethics Committee of Shiraz University of Medical Sciences reviewed and approved the study protocol (IR.SUMS.REC.1396.89). The study protocol was registered at www.irct.ir with the identifier no. IRCT20171223038017N1.
Identification
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© 2020 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
