Advertisement
Original Study| Volume 22, ISSUE 6, P1331.e1-1331.e9, June 2021

Download started.

Ok

A Multidisciplinary, Community-Based Program to Reduce Unplanned Hospital Admissions

  • Ching Shan Wan
    Affiliations
    Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia
    Search for articles by this author
  • Jade Mitchell
    Affiliations
    Department of Medicine and Community Care, The Royal Melbourne Hospital, Parkville, VIC, Australia
    Search for articles by this author
  • Andrea B. Maier
    Correspondence
    Address correspondence to Andrea B. Maier, MD, PhD, Department of Medicine and Aged Care, @Age, Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, VU University Amsterdam, Amsterdam Movement Sciences, van der Boechorststraat 7, 1081 BT, Amsterdam, the Netherlands.
    Affiliations
    Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia

    Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands
    Search for articles by this author
Open AccessPublished:November 05, 2020DOI:https://doi.org/10.1016/j.jamda.2020.09.034

      Abstract

      Objectives

      To evaluate the effect of Hospital Admission Risk Program (HARP) on unplanned hospitalization, bed days, and mortality of enrolled individuals and to evaluate the cost-effectiveness of HARP.

      Design

      A retrospective longitudinal analysis of hospital administrative data.

      Intervention

      Individuals at risk of hospitalization were provided with multidisciplinary, community-based care support managed by care coordinators including integrated care planning, education, monitoring, service linkages, and general practitioner liaison over 6-9 months.

      Setting and Participants

      Individuals who were enrolled into 1 of 8 HARP chronic disease management programs between July 1, 2017, and June 30, 2018, at the Royal Melbourne Hospital, Australia.

      Methods

      Hospital admissions between 18 months before and 18 months after HARP enrollment were analyzed. Total hospital costs were compared between 18 months before and 12 months after HARP enrollment.

      Results

      A total of 1553 individuals with a median age of 71 years (interquartile range 60-81), 63.4% males, were admitted to HARP. Both unplanned hospitalizations and bed days were reduced during the HARP intervention compared to within 3 months before enrollment in each of the HARP management programs. After the HARP intervention, cardiac coach, cardiac heart failure, chronic respiratory, diabetes comanagement, and medication management programs had higher hospitalizations and bed days than individuals’ baseline of at least 3 months before HARP enrollment. Individuals in cardiac heart failure and chronic respiratory management programs had a higher mortality rate than other HARP chronic disease management programs. Individuals in cardiac coach, diabetes comanagement, and medication management programs had lower hospital costs during the HARP intervention compared to within 3 months before HARP enrollment.

      Conclusions and Implications

      HARP reduced unplanned hospitalization and bed days but did not return individuals’ hospital use to baseline before the intervention. The variations in mortality between HARP chronic disease management programs implies that condition-specific goals between programs is preferable.

      Keywords

      Over the last decade, the incidence of rehospitalization has been steadily increasing in developed countries
      • Hakim M.A.
      • Garden F.L.
      • Jennings M.D.
      • et al.
      Performance of the LACE index to predict 30-day hospital readmissions in patients with chronic obstructive pulmonary disease.
      because of an increasing life expectancy and number of chronic conditions.
      • Damery S.
      • Flanagan S.
      • Combes G.
      Does integrated care reduce hospital activity for patients with chronic diseases? An umbrella review of systematic reviews.
      In England, almost half the annual National Health Service financial expenditure has been put toward acute hospital care.
      • Smith P.
      • McKeon A.
      • Blunt I.
      • et al.
      NHS hospitals under pressure: Trends in acute activity up to 2022.
      In Australia, more than 60% of the hospital-based health care budget is dedicated to chronic conditions related inpatient services.
      • Lawn S.
      • Zabeen S.
      • Smith D.
      • et al.
      Managing chronic conditions care across primary care and hospital systems: Lessons from an Australian Hospital Avoidance Risk Program using the Flinders Chronic Condition Management Program.
      ,
      Australian Institute of Health and Welfare
      Australian burden of disease study: Impact and cause of illness and death in Australia 2011.
      Approximately 45% of all potentially preventable hospitalizations are related to chronic conditions,
      Australian Commission on Safety and Quality in Health Care
      A guide to the potentially preventable hospitalizations indicator in Australia.
      which significantly impacts the quality of life of the affected patients. Therefore, reducing avoidable hospitalization associated with chronic conditions has become one of the major priorities of policy makers in order to relieve hospital burden.
      • Pauly V.
      • Mendizabal H.
      • Gentile S.
      • et al.
      Predictive risk score for unplanned 30-day rehospitalizations in the French universal health care system based on a medico-administrative database.
      Integrated care improves chronic disease self-management, quality of life, and subsequently reduces hospital readmissions and mortality because of the core principle of care coordination between the hospital and primary health care providers, and facilitates timely and effective continuity of care for individuals.
      • Ditewig J.B.
      • Blok H.
      • Havers J.
      • van Veenendaal H.
      Effectiveness of self-management interventions on mortality, hospital readmissions, chronic heart failure hospitalization rate and quality of life in patients with chronic heart failure: A systematic review.
      ,
      • Benbassat J.
      • Taragin M.I.
      The effect of clinical interventions on hospital readmissions: A meta-review of published meta-analyses.
      Most programs are disease specific and involve 1 or a combination of interventions such as patient education, case management, medication reconciliation, home visits, and telephone follow-up.
      • Leppin A.L.
      • Gionfriddo M.R.
      • Kessler M.
      • et al.
      Preventing 30-day hospital readmissions: A systematic review and meta-analysis of randomized trials.
      • Howard R.
      • Sanders R.
      • Lydall-Smith S.
      The implementation of Restoring Health—A chronic disease model of care to decrease acute health care utilization.
      • Facchinetti G.
      • D’Angelo D.
      • Piredda M.
      • et al.
      Continuity of care interventions for preventing hospital readmission of older people with chronic diseases: A meta-analysis.
      Programs with multiple interventions, individualized care delivery, and those that support patient capacity for self-care are key features of an effective program for reducing the risk of all-cause or unplanned readmissions and mortality.
      • Leppin A.L.
      • Gionfriddo M.R.
      • Kessler M.
      • et al.
      Preventing 30-day hospital readmissions: A systematic review and meta-analysis of randomized trials.
      A recent umbrella review showed that chronic care models with multiple components and the involvement of a condition-specific multidisciplinary team reduced admission rates.
      • Damery S.
      • Flanagan S.
      • Combes G.
      Does integrated care reduce hospital activity for patients with chronic diseases? An umbrella review of systematic reviews.
      In Australia, the Victorian State Government invested $150 million to develop the Hospital Admission Risk Program (HARP) to provide chronic disease management programs to target specific chronic diseases.
      • Howard R.
      • Sanders R.
      • Lydall-Smith S.
      The implementation of Restoring Health—A chronic disease model of care to decrease acute health care utilization.
      HARP provides intensive care coordination and multidisciplinary disease-specific input to patients with chronic, complex conditions and intensive complex care coordination needs aiming to prevent hospital admissions and improve patient self-management and independence in the community.
      Department of Health & Human Services
      Hospital Admission Risk Program Monitoring Measures.
      HARP reduces emergency department presentations, inpatient admissions, and bed days of individuals with chronic obstructive pulmonary disease and chronic heart failure.
      • Bird S.
      • Noronha M.
      • Sinnott H.
      An integrated care facilitation model improves quality of life and reduces use of hospital resources by patients with chronic obstructive pulmonary disease and chronic heart failure.
      However, the longitudinal analysis of hospitalization of other HARP chronic disease management programs, mortality, and cost has not yet been performed.
      The aim of the study was to determine the rate of hospitalization, bed days, and mortality in individuals admitted to HARP, and to evaluate the cost-effectiveness of the multidisciplinary, community-based service.

      Methods

      Study Intervention

      HARP is a partnership between the Royal Melbourne Hospital in metropolitan Melbourne and community health services to provide assessment, integrated care planning and coordination, specialist medical care, multidisciplinary services, education and monitoring, service linkages, and general practitioner (GP) liaison. The multidisciplinary team includes physicians, nurses, social workers, physiotherapists, pharmacists, occupational therapists, dietitians, and care coordinators.
      Individuals enter HARP via a discharge planning staff member or community referrers who undertake HARP screening for eligibility into the program by reviewing the patient's hospital admissions in the past year to determine if they were potentially avoidable (defined as admissions that could have been avoided by timely and adequate community interventions that prevent deterioration or exacerbation that lead to hospital admission), and if patients are at imminent risk of admitting (due to deterioration or exacerbation of their condition where community supports were either not available or not used effectively). Individuals with complex medical or psychosocial needs such as depression and anxiety, mental health issues not eligible for specialist mental health service, medication management issues, social isolation, fragile support system, and high carer stress, and with 1 or more avoidable emergency presentation or hospital admission to the Royal Melbourne Hospital in the past 12 months or at imminent risk of hospitalization where community services cannot meet their needs, are eligible for HARP. Individuals are eligible when their hospitalizations become more frequent. Individuals with acute psychiatric needs, palliative care needs, aged below 18 years, or adequately managed by community services are not eligible for HARP.
      Once admitted to the HARP, the care coordinator (nurse or allied health background) contacts individuals within 3 working days, first face-to-face contact within 10 working days, followed by regular contact [average 2 (range 1-3) contacts per week] to support the individual to reach their goals as defined in their individualized care plan, which was tailored to each individual based on their needs.
      The aim of the HARP program was to reduce individual's admissions to hospital by linking tertiary care to community supports and their GP for ongoing management. The care plan involved the HARP care coordinator working directly with the individual and GP, other health care professionals, and support services in the community, acting as a central point to arrange, refer, and coordinate services to build their self-management and independence to live at home and manage their condition(s) independently. The individual's condition(s) and needs would determine which HARP care coordinator they were managed by and which other multidisciplinary HARP staff were involved.
      Common features of the management program included hospital and GP liaison, community service referral, and overarching care coordination to become better connected to their GP and community resources to improve their independence at home.
      Department of Health & Human Services
      Hospital Admission Risk Program Monitoring Measures.
      Additionally, each of the 8 HARP chronic disease management programs (cardiac coach, chronic heart failure, chronic respiratory, diabetic foot management, HIV, diabetes comanagement, medication management, and service facilitation) provided a tailored disease-specific service as summarized in Supplementary Table 1. Services were generally delivered in the home, yet individuals were also able to attend outpatient or community centers where required for wound management, medical review, or specialist support. Services delivered included personal care, home care (showering, dressing, meal preparation, cleaning), nursing care, medication management, rehabilitation support from physiotherapists or occupational therapists, social support, and medical reviews.
      Individuals were discharged from HARP if their individualized goals of the care plan were met, including self-managing their medications, or services were in place to support their independence in the community, including nursing and allied health, or home and personal care, and food shopping or meal preparation. The length of inclusion in the program varied from several months up to 1 year.
      Department of Health & Human Services
      Hospital Admission Risk Program Monitoring Measures.

      Participants

      Individuals enrolled in at least 1 of the 8 HARP chronic disease management programs between July 1, 2017, and June 30, 2018, were included in the present analysis. If individuals were enrolled in several HARP chronic disease management programs, their primary chronic disease program allocation was defined based on disease severity in the following order: cardiac coach, cardiac heart failure, chronic respiratory, diabetes foot management, HIV, diabetes comanagement, medication management, and service facilitation.

      Data Collection

      Hospitalization, bed days and mortality were extracted from the patient administration system from January 1, 2016, to December 31, 2019 (equivalent to 18 months before and 18 months after HARP enrollment). Total hospital cost was defined as the summation of hospital services costs in each inpatient episode and HARP staff costs in each HARP chronic disease management programs to provide relevant services. Hospital costs were available until July 1, 2019, from the hospital administration system.
      The number of unplanned hospitalizations (defined as hospitalization excluding elective admissions for follow-up surgical or medical treatments), bed days, and total hospital costs before and after HARP enrollment were compared between 4 time frames stratified by HARP chronic disease management programs and number of chronic disease programs enrolled: (1) 18-4 months before HARP enrollment—individual's baseline; (2) 3 months to HARP enrollment: establishment phase of frequent hospital presentations and becoming HARP eligible; (3) HARP enrollment to the median duration of HARP chronic disease management programs intervention—HARP intervention; (4) median duration of HARP chronic disease programs intervention to 18 months after HARP enrollment—post HARP intervention phase. Age, sex, Australian born, nonindigenous, interpreter use, and being married were extracted from The Care Manager (TCM) and i.Patient Manager (iPM).

      Statistical Analysis

      Descriptive characteristics were presented as mean and standard deviation for normally distributed data or as median and interquartile range for data that were not normally distributed. Categorical variables were presented as a numeric value (n) with percentages (%). To compare the change of unplanned hospitalizations and bed days in the 4 time frames, univariable linear regression analyses were performed to determine beta coefficients and standard errors (SEs). Beta-beta analyses were used to examine group differences in hospitalization rates and bed days between time frames stratified by HARP chronic disease management programs. Nonparametric Wilcoxon matched-pairs signed rank test was used to compare differences in total hospital costs between time frames. Log rank test in Kaplan-Meier survival analysis and Cox regression adjusting for age and gender were used to detect differences in mortality patterns between HARP chronic disease management programs and number of chronic disease programs enrolled.
      • Goel M.K.
      • Khanna P.
      • Kishore J.
      Understanding survival analysis: Kaplan-Meier estimate.
      ,
      • Agarwal G.G.
      Statistics for surgeons—Understanding survival analysis.
      In Cox regression analyses, the cardiac coach and individuals enrolled in 1 chronic disease management program were the reference group for comparison with all other HARP chronic disease programs and number of chronic disease programs (expressed as hazard ratio and 95% confidence interval). Statistical analyses were conducted using the Statistical Package for Social Sciences (IBM SPSS for Windows, version 25.0; IBM Corp, Armonk, NY).

      Results

      Patient Characteristics

      Table 1 shows demographics of 1553 individuals enrolled into HARP. Individuals had a median age of 71 years (interquartile range: 60-81) (63.4% male) and were enrolled in the cardiac coach (27.2%), cardiac heart failure (14.6%), chronic respiratory (15.2%), diabetes foot management (17.4%), HIV (3.5%), diabetes comanagement (11.8%), medication management (7.5%), and service facilitation (2.8%) chronic disease management programs. Twenty-five percent of individuals were admitted to more than 1 HARP chronic disease program. The median duration of HARP enrollment was 272 days (interquartile range: 119-525). Individuals in cardiac coach and HIV programs were more likely to be enrolled in only 1 chronic disease program and were younger than individuals in other chronic disease programs.
      Table 1Demographics of Individuals at HARP Enrollment Stratified by Chronic Disease Management Programs
      VariableCardiac Coach (n = 423)Cardiac Heart Failure (n = 227)Chronic Respiratory (n = 236)Diabetes Foot Management (n = 270)HIV (n = 55)Diabetes Comanagement (n = 183)Medication Management (n = 116)Service Facilitation (n = 43)Total (n = 1553)
      Age, y, median (IQR)63 (55, 70)84 (79, 88)75 (64, 82)67 (58, 77)43 (35, 52)72 (61, 81)80 (69, 85)79 (69, 84)71 (60, 81)
      Male324 (76.6)122 (53.7)136 (57.6)193 (71.5)39 (70.9)98 (53.6)59 (50.9)13 (30.2)984 (63.4)
      Australian born281 (66.4)52 (22.9)123 (52.1)160 (59.3)26 (47.3)76 (41.5)38 (32.8)22 (51.2)778 (50.1)
      Non-Indigenous409 (96.7)227 (100)234 (99.2)265 (98.1)52 (94.5)183 (100)115 (99.1)43 (100)1528 (98.4)
      Interpreter, yes14 (3.3)115 (50.7)46 (19.5)49 (18.1)12 (21.8)57 (31.1)47 (40.5)15 (34.9)355 (22.9)
      Married, de facto261 (61.7)105 (46.3)109 (46.2)149 (55.2)10 (18.2)92 (50.3)53 (45.7)8 (18.6)787 (50.7)
      Management programs, n
       1388 (91.7)100 (44.1)163 (69.1)189 (70.0)53 (96.4)141 (77.0)87 (75.0)43 (100.0)1164 (75.0)
       223 (5.4)84 (37.0)63 (26.7)65 (24.1)2 (3.6)37 (20.2)29 (25.0)303 (19.5)
       3 or more12 (2.8)43 (19.0)10 (4.2)16 (5.9)5 (2.7)86 (5.5)
      Intervention, d, median (IQR)195 (121, 327)385 (216, 536)362 (190, 524)396 (198, 540)413 (365, 542)252 (121, 524)52 (22, 96)66 (17, 185)272 (119, 525)
      IQR, interquartile range.
      Unless otherwise noted, variables are presented as number (percentage).

      Hospitalization and Bed Days

      Figure 1 illustrates the cumulative number of unplanned hospitalizations, total bed days, and bed days per individual before and after HARP enrollment, stratified by HARP chronic disease management programs and number of chronic disease programs enrolled. Similar cumulative trends in hospitalizations and bed days were observed for all chronic disease programs. Table 2 presents results of comparing unplanned hospitalizations and bed days between the 4 time frames. Individuals in all HARP chronic disease programs had higher number of unplanned hospitalizations and number of bed days within 3 months before HARP enrollment compared to other time frames (P < .001). During the HARP intervention, the number of unplanned hospitalization rates and number of bed days reduced significantly compared to 3 months before HARP enrollment (P < .001), regardless of the numbers of chronic disease programs enrolled (P < .001). Unplanned hospitalization rates were higher after the HARP intervention compared with baseline in all HARP chronic disease programs (P < .001). The number of bed days was higher post HARP intervention compared to baseline except of the diabetes foot management (P = .150), HIV (P = .841), and service facilitation (P = .403) programs. Individuals enrolled in more HARP chronic disease programs had a higher number of bed days compared with individuals enrolled in 1 chronic disease program.
      Figure thumbnail gr1
      Fig. 1(A, D) Cumulative number of unplanned hospitalizations, (B, E) total bed days, and (C, F) bed days per individual before and after HARP enrollment, stratified by (A-C) HARP chronic disease management programs and (D-F) number of chronic disease programs enrolled.
      Table 2Comparison of Unplanned Hospitalizations and Bed Days for the 4 Time Frames Stratified by HARP Chronic Disease Management Programs and Number of Chronic Disease Programs Enrolled
      VariableTime FramesP Value
      Baseline, B (SE)3 mo Prior Enrollment, B (SE)HARP Intervention, B (SE)Post HARP Intervention, B (SE)Between All Time FramesBetween 3 mo Prior Enrollment and HARP InterventionBetween Baseline and Post HARP Intervention
      Hospitalizations by chronic disease management programs
       Cardiac coach (n = 423)5.06 (0.31)157.00 (81.41)16.80 (0.74)7.00 (0.48)<.001<.001<.001
       Cardiac heart failure (n = 227)13.27 (0.68)96.00 (38.11)29.69 (0.68)29.17 (1.44)<.001<.001<.001
       Chronic respiratory (n = 236)11.83 (0.56)87.00 (31.18)25.07 (0.46)22.33 (0.39)<.001<.001<.001
       Diabetes foot management (n = 270)10.41 (0.58)58.00 (20.21)16.98 (0.29)13.83 (0.48)<.001<.001.004
       HIV (n = 55)0.48 (0.04)7.50 (2.02)0.70 (0.09)0.67 (0.39)<.001<.001<.001
       Diabetes comanagement (n = 183)7.66 (0.55)66.00 (23.09)12.00 (0.32)11.17 (0.10)<.001<.001.002
       Medication (n = 116)6.63 (0.24)50.50 (15.88)7.50 (2.02)11.91 (0.44)<.001<.001<.001
       Service facilitation (n = 43)2.50 (0.26)17.50 (3.75)2.50 (0.29)3.26 (0.15)<.001<.001<.001
      Hospitalizations by number of chronic disease management programs enrolled
       1 (n = 1164)36.20 (1.85)385.00 (160.50)61.06 (1.90)52.87 (1.81)<.001<.001<.001
       2 (n = 303)15.72 (0.69)118.50 (41.86)35.46 (0.98)31.17 (1.64)<.001<.001<.001
       3 or more (n = 86)5.92 (0.47)36.00 (13.28)17.95 (0.57)14.50 (0.87)<.001<.001<.001
      Bed days by chronic disease management programs
       Cardiac coach (n = 423)24.29 (2.44)903.44 (484.41)36.84 (1.95)34.66 (3.57)<.001<.001<.001
       Cardiac heart failure (n = 227)88.31 (6.60)751.94 (220.20)265.06 (10.79)321.91 (28.08)<.001<.001<.001
       Chronic respiratory (n = 236)61.61 (3.38)374.11 (112.30)176.33 (12.22)171.06 (22.43)<.001<.001<.001
       Diabetes foot management (n = 270)104.35 (12.23)661.33 (85.45)218.79 (13.37)135.66 (8.06)<.001<.001.15
       HIV (n = 55)4.51 (2.00)215.69 (110.42)1.69 (0.27)5.81 (3.35)<.001<.001.84
       Diabetes comanagement (n = 183)45.41 (4.27)549.98 (53.13)78.89 (6.45)104.31 (5.37)<.001<.001<.001
       Medication (n = 116)53.89 (5.48)630.68 (12.89)69.16 (25.58)179.83 (13.81)<.001<.001<.001
       Service facilitation (n = 43)11.79 (2.21)138.57 (27.53)85.07 (36.96)13.49 (0.67)<.001<.001.40
      Bed days by number of chronic disease management programs enrolled
       1 (n = 1164)0.23 (0.02)2.57 (0.62)0.46 (0.04)0.43 (0.03)<.001<.001<.001
       2 (n = 303)0.33 (0.02)3.04 (0.76)0.99 (0.05)0.89 (0.11)<.001<.001<.001
       3 or more (n = 86)0.26 (0.04)3.63 (1.21)1.33 (0.06)1.58 (0.14)<.001<.001<.001
      B, unstandardized beta coefficient; SE, standard error.
      Baseline: 18-4 months before HARP enrollment; 3 months prior enrollment: 3 months before HARP enrollment to HARP enrollment; HARP intervention: during the HARP intervention; post HARP intervention: after HARP intervention.

      Mortality

      Figure 2 illustrates Kaplan-Meier survival curves for individuals stratified by HARP chronic disease management programs (Figure 1A) and number of chronic disease programs enrolled (Figure 1B). The overall 18-month survival rate was 88.5%, but it differed significantly between HARP chronic disease programs (Supplementary Table 2; log rank test P < .001). After adjusting for age and gender, individuals in the cardiac heart failure (hazard ratio 5.96, 95% confidence interval 2.90-12.24; Supplementary Table 2) and chronic respiratory (hazard ratio 5.15, 95% confidence interval 2.53-10.50) programs had higher mortality rates compared to the cardiac coach programs as the referent group. No difference in survival rates between the number of chronic disease programs enrolled was found (P = .222).
      Figure thumbnail gr2
      Fig. 2Kaplan-Meier survival curves for individuals after HARP enrollment, stratified by (A) HARP chronic disease management programs and (B) number of chronic disease programs enrolled.

      Hospital Costs

      Table 3 shows monthly total hospital costs before and after HARP enrollment stratified by HARP chronic disease management programs and number of chronic disease programs enrolled. The monthly total hospital costs during the HARP intervention was lower compared to within 3 months before HARP enrollment (P < .001), irrespective of the number of programs enrolled (P = .001). Individuals in cardiac coach (P < .001), cardiac heart failure (P < .001), diabetes comanagement (P = .001), and medication management (P < .001) programs had lower monthly total hospital costs during the HARP intervention compared to within 3 months before HARP enrollment. The monthly total hospital costs post HARP intervention was higher compared with baseline (P < .001). Individuals enrolled in cardiac coach (P < .001), diabetes comanagement (P = .042), and medication management programs (P = .004) and individuals in 1 HARP chronic disease program (P < .001) had higher monthly total hospital costs post HARP intervention compared with their baseline.
      Table 3Monthly Hospital Costs per Individual in Australian Dollars Before and After HARP Enrollment, Stratified by HARP Chronic Disease Management Programs and Number of Chronic Disease Management Programs Enrolled
      VariableTime FramesP Value
      Wilcoxon matched-pairs signed rank test.
      Time FramesP Value
      Wilcoxon matched-pairs signed rank test.
      3 mo Prior Enrollment, Median (IQR)HARP Intervention, Median (IQR)Baseline, Median (IQR)Post HARP Intervention, Median (IQR)
      By HARP chronic disease management programs
       Cardiac coach (n = 423)2641 (16, 4685)431 (411, 448)<.00137 (0, 64)68 (0, 727)<.001
       Cardiac heart failure (n = 227)2055 (546, 5129)762 (421, 1618)<.00144 (0, 782)
       Chronic respiratory (n = 236)1079 (70, 2414)833 (525, 2209).7732 (0, 355)
       Diabetes foot management (n = 270)836 (151, 3749)662 (406, 1460).2250 (0, 438)
       HIV (n = 55)471 (230, 1132)662 (311, 1301).1022 (0, 502)
       Diabetes comanagement (n = 183)1524 (398, 4578)670 (625, 1500).00141 (0, 144)92 (0, 347).042
       Medication (n = 116)2712 (268, 9557)435 (269, 1735)<.00146 (0, 536)74 (0, 1146).004
       Service facilitation (n = 43)962 (148, 3743)1466 (531, 2299).5450 (0, 412)70 (0, 335).80
      By number of chronic disease management programs enrolled
       1 (n = 1164)1237 (89, 4235)554 (411, 1171)<.00129 (0, 149)68 (0, 301)<.001
       2 (n = 303)1688 (395, 4828)1036 (625, 1902)<.00159 (0, 489)70 (0, 877).53
       3 or more (n = 86)2080 (271, 6194)937 (429, 2250).00173 (0, 741)92 (0, 1180).14
      Total (n = 1553)1384 (99, 4419)625 (411, 1454)<.00138 (0, 171)74 (0, 351)<.001
      IQR, interquartile range.
      Baseline: 18-4 months before HARP enrollment; 3 months prior enrollment: 3 months before HARP enrollment to HARP enrollment; HARP intervention: during the HARP intervention; post HARP intervention: after HARP intervention.
      Wilcoxon matched-pairs signed rank test.

      Discussion

      Individuals in all HARP chronic disease management programs had the highest number of unplanned hospitalization rates, bed days, and total hospital costs 3 months before HARP enrollment, and these were lower during the HARP intervention. Hospitalization rates, bed days, and total hospital costs were higher post HARP intervention compared to baseline. Individuals enrolled in the chronic heart failure and chronic respiratory programs had the least survival rate.
      A reduction in unplanned hospitalization rates and bed days during the HARP intervention compared to the 3 months before HARP enrollment time frame illustrates the effectiveness of the HARP program reducing potentially avoidable unplanned readmissions. Increased unplanned hospitalization and bed days 3 months before HARP enrollment show the integrated and intensive care needs of the individuals.
      • Lawn S.
      • Zabeen S.
      • Smith D.
      • et al.
      Managing chronic conditions care across primary care and hospital systems: Lessons from an Australian Hospital Avoidance Risk Program using the Flinders Chronic Condition Management Program.
      After HARP enrollment, unplanned hospitalizations and bed days were reduced. This result concurs with previous literature that the HARP program reduced emergency department presentations, inpatient admissions, and bed days of HARP individuals with chronic obstructive pulmonary disease and chronic heart failure compared to hospital use before HARP enrollment.
      • Lawn S.
      • Zabeen S.
      • Smith D.
      • et al.
      Managing chronic conditions care across primary care and hospital systems: Lessons from an Australian Hospital Avoidance Risk Program using the Flinders Chronic Condition Management Program.
      ,
      • Howard R.
      • Sanders R.
      • Lydall-Smith S.
      The implementation of Restoring Health—A chronic disease model of care to decrease acute health care utilization.
      ,
      • Bird S.
      • Noronha M.
      • Sinnott H.
      An integrated care facilitation model improves quality of life and reduces use of hospital resources by patients with chronic obstructive pulmonary disease and chronic heart failure.
      ,
      • Peart A.
      • Lewis V.
      • Barton C.
      • et al.
      Providing person-centred care for people with multiple chronic conditions: Protocol for a qualitative study incorporating client and staff perspectives.
      Programs with multidisciplinary clinical management, care coordination and community-based interventions are effective in reducing readmissions and bed days.
      • Coffey A.
      • Leahy-Warren P.
      • Savage E.
      • et al.
      Interventions to promote early discharge and avoid inappropriate hospital (re)admission: A systematic review.
      ,
      • Verhaegh K.J.
      • MacNeil-Vroomen J.L.
      • Eslami S.
      • et al.
      Transitional care interventions prevent hospital readmissions for adults with chronic illnesses.
      Unplanned hospitalization, bed days, and total hospital costs of individuals were higher post HARP intervention compared to their baseline. The included individuals were relatively old, experienced complex comorbidities, and had a history of frequent admissions; therewith, the likely progressive nature of the patient's conditions has to be acknowledged. HARP aims to return patients to their baseline function and health; however, this is often impossible in the context of disease progression. Therewith, higher costs compared to baseline were expected. This result is inconsistent with previous literature, possibly because of the use of different research methodologies and definitions. A systematic review on randomized controlled trials found that transitional care interventions were effective in both reducing intermediate (31-180 days) and long-term (180-365 days) readmissions for adults with chronic diseases compared to individuals without transitional care.
      • Verhaegh K.J.
      • MacNeil-Vroomen J.L.
      • Eslami S.
      • et al.
      Transitional care interventions prevent hospital readmissions for adults with chronic illnesses.
      Transitional care interventions such as Hospital in the Home or community transition care programs admit individuals for a predominantly short period of time to facilitate their needs after hospitalization. In contrast, the HARP program follows individuals for a longer time and operates in conjunction with transitional care programs. Two studies found that chronic disease management programs had reduced readmissions and hospital expenditure by comparing readmissions and costs before and after interventions, but they did not rule out the period when intensive inpatient care was necessary and did not take program cost into consideration.
      • Schumacher C.
      • Moaddab G.
      • Colbert M.
      • et al.
      The effect of clinical pharmacists on readmission rates of heart failure patients in the accountable care environment.
      ,
      • Lovelace D.
      • Hancock D.
      • Hughes S.S.
      • et al.
      A patient-centered transitional care case management program: Taking case management to the streets and beyond.
      A progressive reduction in survival probability of HARP enrolled individuals implies that they might barely return to their baseline of at least 3 months before HARP enrollment due to the progression of complex health conditions, which requires more costly hospital-based acute inpatient care at the end of life.
      • Morrison R.S.
      • Dietrich J.
      • Ladwig S.
      • et al.
      Palliative care consultation teams cut hospital costs for Medicaid beneficiaries.
      Palliative care provision to individuals with advanced diseases not only improves patients' and their families’ satisfaction with care but also reduces hospital costs on intensive care.
      • Penrod J.D.
      • Deb P.
      • Dellenbaugh C.
      • et al.
      Hospital-based palliative care consultation: Effects on hospital cost.
      The involvement of palliative care consultation within 3 days of admission with patients and their families on symptom management, communication, and patient autonomy reduces direct hospital costs.
      • May P.
      • Normand C.
      • Cassel J.B.
      • et al.
      Economics of palliative care for hospitalized adults with serious illness: A meta-analysis.
      Given that it is unknown whether the unplanned hospitalizations after HARP intervention are preventable or not, further research is required to disentangle reasons for these hospitalizations after HARP intervention to provide insights into improving HARP and when palliative care needs to be implemented.
      This study further revealed that chronic disease management programs performed differently in bed days, mortality and cost utilization, which might be due to the differences in patients' disease severity and health care needs. For instance, individuals in the cardiac heart failure and chronic respiratory management programs were older and were more likely to be enrolled in multiple management programs, illustrating more complex health conditions and subsequently higher mortality risk. A patient-centered, proactive, interdisciplinary, and health condition–specific approach is essential to satisfy individuals’ complex health care needs, improve quality of life,
      • Bird S.
      • Noronha M.
      • Sinnott H.
      An integrated care facilitation model improves quality of life and reduces use of hospital resources by patients with chronic obstructive pulmonary disease and chronic heart failure.
      and improve the utilization of hospital resources.
      • Lovelace D.
      • Hancock D.
      • Hughes S.S.
      • et al.
      A patient-centered transitional care case management program: Taking case management to the streets and beyond.
      ,
      • Berntsen G.
      • Dalbakk M.
      • Hurley J.
      • et al.
      Person-centred, integrated and pro-active care for multi-morbid elderly with advanced care needs: A propensity score-matched controlled trial.
      ,
      • Berry D.
      • Costanzo D.M.
      • Elliott B.
      • et al.
      Preventing avoidable hospitalizations: Implementing the transitional care model in home care utilizing evidence-based practice.
      The differences in demographics and survival rates between HARP chronic disease management programs suggest the need for condition-specific goal setting. As the current HARP program enrolled older adults with cardiac heart failure or chronic respiratory when their health was already compromised, it might be worthwhile for care coordinators to assess the need for palliative care rather than focusing on reducing readmission risks.

      Strengths and Limitations

      To our knowledge, this is the first study to evaluate HARP, a multidisciplinary, community-based service, by investigating unplanned hospitalization rates, bed days, mortality, and total costs. As no matched control group was available to evaluate HARP services, hospital administrative data, mortality, and total hospital costs were compared between after HARP intervention and baseline. In studies aimed to evaluate the effectiveness of programs that targeted individuals with high health care utilization without a control group, it could be a potential pitfall to observe a reduction in hospital utilization due to regression to the mean. Yet, a consistent trend of reduced hospital admissions during and after the intervention indicates the effectiveness of the program. Furthermore, total hospital costs were only available between 18 months before and 12 months after HARP, and there was no information on emergency department presentations.

      Conclusions and Implications

      The HARP service model reduced unplanned hospitalization rates, bed days, and total hospital costs during the HARP intervention compared to the time frame when intensive acute care was needed within 3 months before HARP enrollment. However, HARP was ineffective in reducing unplanned hospitalizations, bed days, and total hospital costs back to baseline. Further research is warranted to explore the reasons for hospitalizations after HARP intervention in various HARP chronic disease management programs to determine whether they could potentially be avoided.

      Acknowledgments

      The authors acknowledge the Business Intelligence Unit of Melbourne Health for providing hospital administrative data for data analysis.

      Supplementary Data

      Supplementary Table 1Hospital Admission Risk Program, Chronic Disease Management Programs Overview
      Chronic Disease Management ProgramEligibility CriteriaExclusion CriteriaServices Provided
      Cardiac coach (including chest pain)Atypical chest pain, nonischemic chest pain, angina pectoris, angiogram confirmed ischemic heart disease (IHD), post invasive IHD interventionUnable to participate in phone conversationEducation to support management, postdischarge phone-based coaching
      Cardiac heart failureExacerbation of conditionEducation to support management, clinic review
      Chronic respiratoryExacerbation of chronic obstructive pulmonary disease, asthma, pulmonary of interstitial lung disease, pulmonary hypertensionEducation to support management, advice on physical exercise, medication review and support, respiratory physician review
      Diabetes foot managementDiabetes mellitus with current foot wound(s) or active diabetic complication(s)Wound management, vascular intervention, antibiotic management
      HIVHIV diagnosis with management needsEducation to support management, clinic and outreach support
      Diabetes comanagementPoorly regulated diabetes mellitus due to poor self-managementGestational diabetesEducation to support management, support on insulin use, support for diabetes complication management
      Medication managementPolypharmacy, adaptation to medication changes, adherence concerns, medication reconciliationIndividuals in residential aged careComprehensive home medication assessment, education and referrals as needed
      Service facilitationIndividuals with complex comorbidities and high-level care coordination supportAcute medical requirementsIntensive care coordination, assessment and advocacy, connection with housing, employment, mental health, and other specialist services
      Supplementary Table 2Survival Analysis Using Kaplan-Meier Survival Curve Analysis and Cox Regression
      Variableχ2P Value of χ2Hazard Ratio (95% CI)
      By HARP chronic disease management programs
       Log rank (Mantel-Cox) test in Kaplan-Meier analysis90.5<.001∗
      Cox regression by HARP chronic disease management programs
       Cardiac coach126.4<.001∗Reference
       Cardiac heart failure126.4<.001∗5.96 (2.90, 12.24)∗
       Chronic respiratory126.4<.001∗5.15 (2.53, 10.50)∗
       Diabetes foot management126.4<.001∗4.17 (2.03, 8.56)∗
       HIV126.4<.001∗1.48 (0.19, 11.71)
       Diabetes comanagement126.4<.001∗3.20 (1.45, 7.07)∗
       Medication management126.4<.001∗4.84 (2.20, 10.62)∗
       Service facilitation126.4<.001∗4.07 (1.44, 11.51)∗
      By number of chronic disease management programs
       Log Rank (Mantel-Cox) test in Kaplan-Meier analysis5.7.222
      Cox regression by number of chronic disease management programs enrolled:
       1 chronic disease programs95.8<.001∗Reference
       2 chronic disease programs95.8<.001∗0.99 (0.70, 1.40)
       3 or more chronic disease programs95.8<.001∗1.06 (0.56, 2.02)
      CI, confidence interval.

      References

        • Hakim M.A.
        • Garden F.L.
        • Jennings M.D.
        • et al.
        Performance of the LACE index to predict 30-day hospital readmissions in patients with chronic obstructive pulmonary disease.
        Clin Epidemiol. 2018; 10: 51-59
        • Damery S.
        • Flanagan S.
        • Combes G.
        Does integrated care reduce hospital activity for patients with chronic diseases? An umbrella review of systematic reviews.
        BMJ Open. 2016; 6: e011952
        • Smith P.
        • McKeon A.
        • Blunt I.
        • et al.
        NHS hospitals under pressure: Trends in acute activity up to 2022.
        (Available at:)
        • Lawn S.
        • Zabeen S.
        • Smith D.
        • et al.
        Managing chronic conditions care across primary care and hospital systems: Lessons from an Australian Hospital Avoidance Risk Program using the Flinders Chronic Condition Management Program.
        Aust Health Rev. 2018; 42: 542-549
        • Australian Institute of Health and Welfare
        Australian burden of disease study: Impact and cause of illness and death in Australia 2011.
        Australian Institute of Health and Welfare, Canberra2016
        • Australian Commission on Safety and Quality in Health Care
        A guide to the potentially preventable hospitalizations indicator in Australia.
        (Available at:)
        • Pauly V.
        • Mendizabal H.
        • Gentile S.
        • et al.
        Predictive risk score for unplanned 30-day rehospitalizations in the French universal health care system based on a medico-administrative database.
        PloS One. 2019; 14: e0210714
        • Ditewig J.B.
        • Blok H.
        • Havers J.
        • van Veenendaal H.
        Effectiveness of self-management interventions on mortality, hospital readmissions, chronic heart failure hospitalization rate and quality of life in patients with chronic heart failure: A systematic review.
        Patient Educ Couns. 2010; 78: 297-315
        • Benbassat J.
        • Taragin M.I.
        The effect of clinical interventions on hospital readmissions: A meta-review of published meta-analyses.
        Isr J Health Policy Res. 2013; 2: 1-15
        • Leppin A.L.
        • Gionfriddo M.R.
        • Kessler M.
        • et al.
        Preventing 30-day hospital readmissions: A systematic review and meta-analysis of randomized trials.
        JAMA Intern Med. 2014; 174: 1095-1107
        • Howard R.
        • Sanders R.
        • Lydall-Smith S.
        The implementation of Restoring Health—A chronic disease model of care to decrease acute health care utilization.
        Chron Respir Dis. 2008; 5: 133-141
        • Facchinetti G.
        • D’Angelo D.
        • Piredda M.
        • et al.
        Continuity of care interventions for preventing hospital readmission of older people with chronic diseases: A meta-analysis.
        Int J Nurs Stud. 2019; 103396: 1-10
        • Department of Health & Human Services
        Hospital Admission Risk Program Monitoring Measures.
        Victoria State Government, Department of Health & Human Services, Victoria, Australia2020
        • Bird S.
        • Noronha M.
        • Sinnott H.
        An integrated care facilitation model improves quality of life and reduces use of hospital resources by patients with chronic obstructive pulmonary disease and chronic heart failure.
        Aust J Prim Health. 2010; 16: 326-333
        • Goel M.K.
        • Khanna P.
        • Kishore J.
        Understanding survival analysis: Kaplan-Meier estimate.
        Int J Ayurveda Res. 2010; 1: 274-278
        • Agarwal G.G.
        Statistics for surgeons—Understanding survival analysis.
        Indian J Surg Oncol. 2012; 3: 208-214
        • Peart A.
        • Lewis V.
        • Barton C.
        • et al.
        Providing person-centred care for people with multiple chronic conditions: Protocol for a qualitative study incorporating client and staff perspectives.
        BMJ Open. 2019; 9: e030581
        • Coffey A.
        • Leahy-Warren P.
        • Savage E.
        • et al.
        Interventions to promote early discharge and avoid inappropriate hospital (re)admission: A systematic review.
        Int J Environ Res Public Health. 2019; 16: 1-16
        • Verhaegh K.J.
        • MacNeil-Vroomen J.L.
        • Eslami S.
        • et al.
        Transitional care interventions prevent hospital readmissions for adults with chronic illnesses.
        Health Aff. 2014; 33: 1531-1539
        • Schumacher C.
        • Moaddab G.
        • Colbert M.
        • et al.
        The effect of clinical pharmacists on readmission rates of heart failure patients in the accountable care environment.
        J Manag Care Spec Pharm. 2018; 24: 795-799
        • Lovelace D.
        • Hancock D.
        • Hughes S.S.
        • et al.
        A patient-centered transitional care case management program: Taking case management to the streets and beyond.
        Prof Case Manag. 2016; 21: 277-290
        • Morrison R.S.
        • Dietrich J.
        • Ladwig S.
        • et al.
        Palliative care consultation teams cut hospital costs for Medicaid beneficiaries.
        Health Aff. 2011; 30: 454-463
        • Penrod J.D.
        • Deb P.
        • Dellenbaugh C.
        • et al.
        Hospital-based palliative care consultation: Effects on hospital cost.
        J Palliat Med. 2010; 13: 973-979
        • May P.
        • Normand C.
        • Cassel J.B.
        • et al.
        Economics of palliative care for hospitalized adults with serious illness: A meta-analysis.
        JAMA Intern Med. 2018; 178: 820-829
        • Berntsen G.
        • Dalbakk M.
        • Hurley J.
        • et al.
        Person-centred, integrated and pro-active care for multi-morbid elderly with advanced care needs: A propensity score-matched controlled trial.
        BMC Health Serv Res. 2019; 19: 1-17
        • Berry D.
        • Costanzo D.M.
        • Elliott B.
        • et al.
        Preventing avoidable hospitalizations: Implementing the transitional care model in home care utilizing evidence-based practice.
        Home Healthcare Nurse. 2011; 29: 540-549