Abstract
Objectives
Obesity may increase the risk of kidney function decline. However, few studies have
addressed how age modifies obesity-associated risk of chronic kidney disease (CKD)
in the Asian general population.
Design
A community-based prospective cohort study.
Setting and Participants
6538 Korean general population with normal kidney function from the Korean Genome
and Epidemiology Study Database.
Methods
Participants were stratified according to age (40–49, 50–59, and 60-69 years old)
and body mass index [≥18.5–<23 (normal-weight), ≥23–<27.5 (overweight), and ≥27.5
(obese)]. We conducted Kaplan-Meier and multivariable-adjusted Cox regression analyses
to investigate the association of aging and obesity with incident CKD.
Results
During the 12-year follow-up, an overall incidence rate of CKD was 6.1 cases per 1000
person-years. Obese, but not overweight, people had an increased risk of incident
CKD compared with normal-weight people in multivariable models adjusted for metabolic
factors. When analyzed by 10-year increments, this association was significant only
in 60-69-year-old individuals. Kaplan-Meier analysis showed that the incidence of
CKD associated with overweight or obesity showed an accentuated increase with age.
With reference to normal-weight individuals aged 40-49 years, the adjusted hazard
ratio of CKD increased with age regardless of body mass index, and the positive association
between obesity and incident CKD was more prominent with increasing age.
Conclusions and Implications
Obesity-associated risk of incident CKD was accentuated in older people, and this
association was independent of metabolic abnormalities.
Keywords
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Article info
Publication history
Published online: November 22, 2020
Footnotes
SWJ and MC contributed equally to this work and share first authorship.
This research was supported by the National Research Foundation of Korea (NRF-2020R1F1A1048586).
The authors declare no conflicts of interest.
Identification
Copyright
© 2020 Published by Elsevier Inc. on behalf of AMDA - The Society for Post-Acute and Long-Term Care Medicine.
