While the complexity of sarcopenia pathogenesis has been universally accepted, gender-specific
aspects have only received little attention. A recent study on microscopic characteristics
of muscle composition in patients with hip fracture and sarcopenia showed a significant
difference of fiber atrophy between men and women, with type II (“fast-twitch”) fiber
atrophy being present only in men.
1
This observation illustrates the need for a more gender-specific analysis of etiologic
factors in sarcopenia, as this might also have therapeutic implications in the future.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of the American Medical Directors AssociationAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Type-2 muscle fiber atrophy is associated with sarcopenia in elderly men with hip fracture.Exp Gerontol. 2021; 144 (111171)
- European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People.Age Ageing. 2010; 39: 412-423
- Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis.Age Ageing. 2019; 48: 16-31
- The clinical usefulness of muscle mass and strength measures in older people: A systematic review.Age Ageing. 2021; 50: 88-95
- Prevalence and factors associated with poor performance in the 5-chair stand test: findings from the Cognitive Function and Ageing Study II and proposed Newcastle protocol for use in the assessment of sarcopenia.J Cachexia Sarcopenia Muscle. 2021; (Jan 18. [Epub ahead of print])
- Impact of low muscle mass and low muscle strength according to EWGSOP2 and EWGSOP1 in community-dwelling older people.J Gerontol A Biol Sci Med Sci. 2020; 75: 1324-1330
- Sarcopenia, low handgrip strength, and low absolute muscle mass predict long-term mortality in older hospitalized patients: An observational inception cohort study.J Am Med Dir Assoc. 2021; 22: 816-820
- Editorial: Body composition measurements in older adults.Curr Opin Clin Nutr Metab Care. 2020; 23: 1-3
- Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment.J Am Med Dir Assoc. 2020; 21: 300-307
- Muscle mass assessed by the D3-Creatine dilution method and incident self-reported disability and mortality in a prospective observational study of community-dwelling older men.J Gerontol A Biol Sci Med Sci. 2021; 76: 123-130
- The association of muscle mass measured by D3-creatine dilution method with dual energy X-ray absorptiometry and physical function in postmenopausal women.J Gerontol A Biol Sci Med Sci. 2021; (Jan 21. [Epub ahead of print])
- D3 -Creatine dilution and the importance of accuracy in the assessment of skeletal muscle mass.J Cachexia Sarcopenia Muscle. 2019; 10: 14-21
- Application of ultrasound for muscle assessment in sarcopenia: 2020 SARCUS update.Eur Geriatr Med. 2021; 12: 45-59
- SARC-F for screening of sarcopenia among older adults: A meta-analysis of screening test accuracy.J Am Med Dir Assoc. 2018; 19: 685-689
- Assessing the risk of sarcopenia in the elderly: The Mini Sarcopenia Risk Assessment (MSRA) questionnaire.J Nutr Health Aging. 2017; 21: 743-749
- The Mini Sarcopenia Risk Assessment (MSRA) Questionnaire score as a predictor of skeletal muscle mass loss.Aging Clin Exp Res. 2021; (Jan 2. [Epub ahead of print])
- Bimagrumab vs optimized standard of care for treatment of sarcopenia in community-dwelling older adults: A randomized clinical trial.JAMA Netw Open. 2020; 3: e2020836
- Exercise programs for muscle mass, muscle strength and physical performance in older adults with sarcopenia: A systematic review and meta-analysis.Aging Dis. 2020; 11: 863-873
- Interventions to ameliorate reductions in muscle quantity and function in hospitalised older adults: a systematic review towards acute sarcopenia treatment.Age Ageing. 2020; 50: 394-404
- Dietary intake, D3Cr muscle mass, and appendicular lean mass in a cohort of older men.J Gerontol A Biol Sci Med Sci. 2020; 75: 1353-1361
- A higher protein intake at breakfast and lunch is associated with a higher total daily protein intake in older adults: A post-hoc cross-sectional analysis of four randomised controlled trials.J Hum Nutr Diet. 2020; (Nov 15. [Epub ahead of print])
- Exercise, nutrition, and combined exercise and nutrition in older adults with sarcopenia: A systematic review and network meta-analysis.Maturitas. 2021; 145: 38-48
- The effect of vitamin D plus protein supplementation on sarcopenia: A systematic review and meta-analysis of randomized controlled trials.Maturitas. 2021; 145: 56-63
- Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study.Clin Nutr. 2018; 37: 551-557
- Dietary patterns, skeletal muscle health, and sarcopenia in older adults.Nutrients. 2019; 11: 745
- Association of nutrient-derived dietary patterns with sarcopenia and its components in community-dwelling older Japanese: A cross-sectional study.Nutr J. 2021; 20: 7
- Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype.J Gerontol A Biol Sci Med Sci. 2011; 56: M146-M156
- Frailty and sarcopenia in combination are more predictive of mortality than either condition alone.Maturitas. 2021; 144: 102-107
- Critical appraisal of definitions and diagnostic criteria for sarcopenic obesity based on a systematic review.Clin Nutr. 2020; 39: 2368-2388
- Prevalence of sarcopenia as a comorbid disease: A systematic review and meta-analysis.Exp Gerontol. 2020; 131 (110801)
- Glycemic control and insulin improve muscle mass and gait speed in type 2 diabetes: The MUSCLES-DM Study.J Am Med Dir Assoc. 2021; 22: 834-838
- Sarcopenia in chronic kidney disease: what have we learned so far?.J Nephrol. 2020; (Sep 2. [Epub ahead of print])
- Muscle wasting and sarcopenia in heart failure-The current state of science.Int J Mol Sci. 2020; 21 (6549)
Article info
Footnotes
This editorial presents findings from recent publications that might influence the future management of patients with sarcopenia. In addition, some still existing, but highly relevant knowledge gaps are identified.
Identification
Copyright
© 2021 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
