I read the recent article published in this journal written by Fan et al
1with great interest. The authors conducted a meta-analysis on the association between frailty and all-cause mortality in older adults. The pooled risk ratios (RRs) of frail women and men for all-cause mortality were 2.41 [95% confidence interval (CI) 2.07-2.80] and 2.94 (95% CI 2.12-4.09), respectively. By using the frailty index, the pooled RRs (95% CIs) of frail women and men for all-cause mortality were 3.23 (2.16-4.83) and 2.63 (2.33-2.98), respectively. There were no significant sex differences in these associations, and I have 2 concerns about their study.
- Fan Y.
- Huang J.
- Zhou Y.
- et al.
Does the impact of frailty on all-cause mortality in older persons differ between women and men? A meta-analysis.
J Am Med Dir Assoc. 2021; 22: 606.e1-606.e6
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- Does the impact of frailty on all-cause mortality in older persons differ between women and men? A meta-analysis.J Am Med Dir Assoc. 2021; 22: 606.e1-606.e6
- Frailty as a predictor of all-cause mortality among older nursing home residents: A systematic review and meta-analysis.J Am Med Dir Assoc. 2019; 20: 657-663.e4
- Frailty, transition in frailty status and all-cause mortality in older adults of a Taichung community-based population.BMC Geriatr. 2019; 19: 26
- Controlling time-dependent confounding by health status and frailty: Restriction versus statistical adjustment.Am J Epidemiol. 2015; 182: 17-25
- Time-dependent predictors in clinical research, performance of a novel method.Am J Ther. 2010; 17: e202-e207
Published online: April 08, 2021
The author declares no conflicts of interest.
© 2021 Published by Elsevier Inc. on behalf of AMDA - The Society for Post-Acute and Long-Term Care Medicine.