Previous evidence has shown that olfactory impairment could be regarded as an early
marker of impending neurodegenerative diseases.
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According to some cohort studies,
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,
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,
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the decline of olfactory function might reflect a wider range of pathologic conditions
irrespective of neurodegeneration, which could contribute to mortality. We intended
to verify the hypothesis that poor olfactory identification could predict long-term
mortality risk in older adults without neurodegenerative diseases by analyzing the
longitudinal data of the Shanghai Aging Study.To read this article in full you will need to make a payment
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References
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- The olfactory vector hypothesis of neurodegenerative disease: Is it viable?.Ann Neurol. 2008; 63: 7-15
- Telomere shortening impairs regeneration of the olfactory epithelium in response to injury but not under homeostatic conditions.PLoS One. 2011; 6: e27801
- Association of coffee drinking with total and cause-specific mortality.N Engl J Med. 2012; 366: 1891-1904
Article info
Publication history
Published online: June 19, 2021
Footnotes
This work was supported by grants of Shanghai Municipal Science and Technology Major Project (2018SHZDZX01) and ZJLab, National Natural Science Foundation of China (81773513, 82071200), Scientific Research Plan Project of Shanghai Science and Technology Committee (17411950701, 17411950106), National Project of Chronic Disease (2016YFC1306402), and Shanghai Sailing Program (20YF1404000).
The authors declare no conflicts of interest.
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