Abstract
Objectives
Understanding disability-adjusted life-years (DALYs) based on dementia subtypes and
mild cognitive impairment (MCI) is essential for optimal resource allocation. This
study aimed to investigate disease burdens of various dementias and MCI in a representative
South Korean population.
Design
Retrospective cohort study.
Setting and Participants
6481 Korean older adults.
Methods
We estimated the disease-specific DALYs.
Results
DALYs due to MCI and all-cause dementia are estimated to increase from 1295 per 100,000
in 2016 to 9501 per 100,000 in 2065. In 2016, DALYs attributed to Alzheimer's dementia,
vascular dementia, and MCI accounted for 33% (423 per 100,000), 20% (316 per 100,000),
and 24% (123 per 100,000), respectively, of the total DALYs due to MCI and all-cause
dementia. In 2065, DALYs due to Alzheimer's dementia, vascular dementia, and MCI will
account for 38% (3654 per 100,000), 17% (1654 per 100,000), and 27% (2585 per 100,000)
of total DALYs due to MCI and all-cause dementia, respectively.
The years of life lived with disability (YLDs) due to MCI and all-cause dementia are
estimated to rise from 479 per 100,000 in 2016 to 2807 per 100,000 in 2065. In 2016,
YLDs due to Alzheimer's dementia, vascular dementia, and MCI composed 37% (177 per
100,000), 18% (85 per 100,000), and 15% (70 per 100,000), respectively, of the total
YLDs due to MCI and all-cause dementia. In 2065, YLDs due to Alzheimer's dementia,
vascular dementia, and MCI will account for 48% (1358 per 100,000), 15% (410 per 100,000),
and 10% (290 per 100,000), respectively, of total YLDs due to MCI and all-cause dementia.
Conclusions and Implications
Considering the rapidly growing disease burden, resources should be allocated to continuously
monitor and manage the MCI and dementia burden. Particular attention to Alzheimer's
dementia is required considering its significant contribution to current and future
disease burden, especially to YLD.
Keywords
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Article info
Publication history
Published online: July 05, 2021
Footnotes
This study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health, Welfare and Family Affairs, Republic of Korea (grant number, A092077).
The authors declare no conflicts of interest.
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© 2021 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
