Direct oral anticoagulants (DOACs) are presented as a good option for older patients
owing to their safety profile. However, the dosing of these drugs can become challenging.
This is due to the fluctuation of renal function in this population, together with
the presence of comorbidities and the concomitant use of other drugs, among other
reasons. Prior studies reported high rates of nonstandard dosing in older patients,
1
increasing the risk of adverse events.
2
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References
- Non-vitamin K antagonist oral anticoagulant dosing in patients with atrial fibrillation and renal dysfunction.J Am Coll Cardiol. 2017; 69: 2779-2790
- On-label reduced doses of non-vitamin K anticoagulants prove safe and efficient; yet how to ensure the correct dose for the right patient?.Eur Heart J. 2019; 40: 1501-1503
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- Off-label dosing of non-vitamin K antagonist oral anticoagulants and adverse outcomes: The ORBIT-AF II Registry.J Am Coll Cardiol. 2016; 68: 2597-2604
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Article info
Publication history
Published online: June 30, 2021
Footnotes
The authors declare no conflicts of interest.
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© 2021 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
