When assessing sarcopenia, physicians usually evaluate muscle mass by the skeletal
muscle mass index (SMI), calculated from appendicular lean mass, measured using a
bioimpedance device.
1
Recently, we proposed creatinine-to-cystatin C ratio (CCR), calculated using circulating
levels of creatinine and cystatin C as a simple marker of muscle mass and fat infiltration
in the muscle (myosteatosis), an indicator of muscle quality.
2
,3
However, whether the CCR was just a proxy of the SMI or represented different muscle
properties from the SMI was unclear. To further clarify CCR's usefulness as a marker
of muscle properties, this study directly compared CCR to SMI in the association with
muscle mass and myosteatosis.To read this article in full you will need to make a payment
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References
- Asian working Group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment.J Am Med Dir Assoc. 2020; 21: 300-307.e2
- Creatinine-to-cystatin C ratio as a marker of skeletal muscle mass in older adults: J-SHIPP study.Clin Nutr. 2020; 39: 1857-1862
- Association of creatinine-to-cystatin C ratio with myosteatosis and physical performance in older adults: The Japan shimanami health promoting program.J Am Med Dir Assoc. 2021; : S1525
- Office-based simple frailty score and central blood pressure predict mild cognitive impairment in an apparently healthy Japanese population: J-SHIPP study.Sci Rep. 2017; 7: 46419
- A guide for using NIH Image J for single slice cross-sectional area and composition analysis of the thigh from computed tomography.PLoS One. 2019; 14: e0211629
- Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: The Health, Aging and Body Composition Study.J Am Geriatr Soc. 2002; 50: 897-904
- Age, gene/environment susceptibility (AGES)-Reykjavik study. Muscle quality and myosteatosis: Novel associations with mortality risk: The age, gene/environment susceptibility (AGES)-Reykjavik study.Am J Epidemiol. 2016; 183: 53-60
- Bioelectrical impedance analysis in body composition measurement: National institutes of health technology assessment conference statement.Am J Clin Nutr. 1996; 64: 524S-532S
- Consequences of applying the new EWGSOP2 guideline instead of the former EWGSOP guideline for sarcopenia case finding in older patients.Age Ageing. 2019; 48: 719-724
Article info
Publication history
Published online: July 19, 2021
Footnotes
This work was supported by a Grant-in-Aid for Scientific Research (20390185, 23659382, 24390084, 23659352, 25293141, 26670313, 17H04123, 21H04850) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan; Research and Development Grants for Longevity Science (dk0110040) from the Japan Agency for Medical Research and Development (AMED); research grant from the Japan Atherosclerosis Prevention Found; National Cardiovascular Research Grants; and Research Promotion Award from the Ehime University.
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