Abstract
Objectives
The predictive ability of the novel intrinsic capacity (IC) construct has been scarcely
investigated in the nursing home setting. The objective of this study was to investigate
the associations of IC and its individual domains with mortality, hospitalization,
pneumonia onset, and functional status decline in a population of nursing home residents
(NHRs).
Design
We undertook an analysis using data from the INCUR study, a prospective observational
study. Data were collected at baseline, at 6 and 12 months by trained staff.
Setting and Participants
A total of 371 NHRs (mean age 85.91 ± 7.34) dwelling in Southern France.
Methods
A baseline IC composite score was constructed from scores in the Short Physical Performance
Battery, Abbreviated Mental Test, 10-item Geriatric Depression Scale, The Short Form
of the Mini-Nutritional Assessment, and self-reported hearing and vision impairments.
Adverse outcomes were registered by medical records checking. Functional status evolution
was evaluated through changes in the Katz Index. Cox regression was used for associations
between IC and its domains and adverse outcomes. Linear mixed models were used in
the case of functional status evolution.
Results
Our analysis revealed associations between a composite score of IC and death [hazard
ratio 0.33; 95% confidence interval (CI) 0.15–0.73] and functional status evolution
(β = 0.14; 95% CI 0.018–0.29) in our population. Although greater values in IC vitality/nutrition
domain were associated with survival (HR 0.84; 95% CI 0.70–0.99), IC cognitive domain
was associated with decreased odds of hospitalization (HR 0.91; 95% CI 0.84–0.99)
and lower declines in functional status (β = 0.04; 95% CI 0.01–0.07), whereas the
IC locomotion domain was inversely associated with pneumonia incidence (HR 0.84; 95%
CI 0.72–0.98).
Conclusions and Implications
Our results contribute to preliminary evidence linking greater IC levels and lower
risk of late-life adverse outcomes.
Keywords
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Article info
Publication history
Published online: October 01, 2021
Footnotes
The INCUR study was supported by Pfizer Holding France (Paris, France). The sponsor had no role in the design of the study, the collection and analysis of the data, or the preparation of the manuscript.
MC has received honoraria from Nestlé Health Sciences for presentations at scientific meetings and for serving as consultant in expert advisory boards. The other authors declare no conflicts of interest.
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