Anticholinergic agents are frequently administered to older people with dementia,
who are more likely to receive multiple drugs, including psychotropic agents, thus
increasing their anticholinergic burden (AB).
1
The unfavorable cognitive, behavioral, and affective side effects of AB accelerate
the trajectory to frailty.
2
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References
- Identifying potentially inappropriate prescribing in older people with dementia: A systematic review.Eur J Clin Pharmacol. 2019; 75: 467-481
- Exposure to atropinic drugs and frailty status.J Am Med Dir Assoc. 2015; 3: 253-257
- Association between anticholinergic burden and anticholinergic adverse outcomes in the elderly: Pharmacological basis of their predictive value for adverse outcomes.Pharmacol Res. 2021; 163: 105306
- The socio familiar scale of Gijon, a useful tool in the hospital setting [La escala sociofamiliar de Gijón, elemento útil en el hospital general].Rev Esp Geriatr Gerontol. 1998; 33 ([in Spanish]): 175-179
- “Mini-Mental state”: A practical method for grading the cognitive state of patients for the clinician.J Psychiatr Res. 1975; 12: 189-198
- Progress in development of the index of ADL.Gerontologist. 1970; 10: 20-30
- A global clinical measure of fitness and frailty in elderly people.CMAJ. 2005; 173: 489-495
- Potentially inappropriate medication, anticholinergic burden, and mortality in people attending memory clinics.J Alzheimers Dis. 2017; 60: 349-358
- Social connectedness, perceived isolation, and dementia: Does the social environment moderate the relationship between genetic risk and cognitive well-being?.Gerontologist. 2017; 57: 1031-1040
Article info
Publication history
Published online: September 27, 2021
Footnotes
A.L. and L.P. are equally contributing first authors.
Identification
Copyright
© 2021 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
