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Translation of Research on Sarcopenia Into Clinical Practice

  • Matteo Cesari
    Correspondence
    Address correspondence to Matteo Cesari, MD, PhD, Geriatric Unit, IRCCS Istituti Clinici Scientifici Maugeri, Via Camaldoli 64, 20138 Milan, Italy.
    Affiliations
    Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

    Geriatric Unit, IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy
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  • Riccardo Calvani
    Affiliations
    Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Rome, Italy

    Department of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden
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  • Marco Canevelli
    Affiliations
    Department of Human Neuroscience, “Sapienza” University, Rome, Italy

    National Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy
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  • Emanuele Marzetti
    Affiliations
    Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Rome, Italy

    Department of Geriatrics and Orthopedics, Università Cattolica del Sacro Cuore, Rome, Italy
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      The debate whether sarcopenia is a clinically relevant condition or just a matter for research is not novel.
      • Cesari M.
      • Vellas B.
      Sarcopenia: a novel clinical condition or still a matter for research?.
      As explained by Bauer in a recent editorial published in this journal,
      • Bauer J.M.
      Muscle function and sarcopenia: clinical implications of recent research.
      the interest for conducting research on sarcopenia has “extended far beyond the field of aging and geriatric medicine, as it has been established as a highly relevant prognostic biomarker for a wide array of diseases.” At the same time, it is normal for a clinician to question whether the inclusion of sarcopenia in the list of active conditions can make any difference for a complex geriatric patient and substantially influence the decision process. Not surprisingly, Haase and colleagues
      • Haase C.B.
      • Brodersen J.B.
      • Bülow J.
      Sarcopenia: early prevention or overdiagnosis?.
      have recently expressed their concerns about the construct of sarcopenia as a disease. In particular, they highlighted several weaknesses nested in its diagnostic framework, which may potentially lead to overdiagnosis.
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