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Comment on “Exercise and Nutritional Intervention for Physical Function of the Prefrail: A Systematic Review and Meta-Analysis”

Published:December 30, 2022DOI:https://doi.org/10.1016/j.jamda.2022.10.023
      Frailty is an age-related syndrome that can progress from nonfrailty (ie, robustness) to prefrail, and then physical frailty.
      • Fried L.P.
      • Tangen C.M.
      • Walston J.
      • et al.
      Frailty in older adults: evidence for a phenotype.
      With the rapidly expanding aging population, there has been a corresponding increase in the number of older adults with frailty, which has placed a greater burden on the health care system.
      • Hoogendijk E.O.
      • Afilalo J.
      • Ensrud K.E.
      • et al.
      Frailty: implications for clinical practice and public health.
      Therefore, developing effective strategies for preventing and managing frailty is imperative. We read with interest the article by Liu et al
      • Liu C.
      • Xu H.
      • Chen L.
      • et al.
      Exercise and nutritional intervention for physical function of the prefrail: a systematic review and meta-analysis.
      published in JAMDA that concluded through meta-analysis that exercise and/or nutritional interventions significantly improved physical function in prefrail older adults. However, there are some methodologic errors in this article, which we discuss here for the benefit of the readers.
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      References

        • Fried L.P.
        • Tangen C.M.
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        • et al.
        Frailty in older adults: evidence for a phenotype.
        J Gerontol A Biol Sci Med Sci. 2001; 56: M146-156
        • Hoogendijk E.O.
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        Frailty: implications for clinical practice and public health.
        Lancet. 2019; 394: 1365-1375
        • Liu C.
        • Xu H.
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        • et al.
        Exercise and nutritional intervention for physical function of the prefrail: a systematic review and meta-analysis.
        J Am Med Dir Assoc. 2022;
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        Chapter 6: choosing effect measures and computing estimates of effect.
        in: Higgins J.P.T. Thomas J. Chandler J. Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022). Cochrane, 2022